Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial

An increased rate of brain atrophy is often observed in older subjects, in particular those who suffer from cognitive decline. Homocysteine is a risk factor for brain atrophy, cognitive impairment and dementia. Plasma concentrations of homocysteine can be lowered by dietary administration of B vitam...

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Bibliographic Details
Published in:	PloS one Vol. 5; no. 9; p. e12244
Main Authors:	Smith, A. David, Smith, Stephen M., de Jager, Celeste A., Whitbread, Philippa, Johnston, Carole, Agacinski, Grzegorz, Oulhaj, Abderrahim, Bradley, Kevin M., Jacoby, Robin, Refsum, Helga
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 08.09.2010 Public Library of Science (PLoS)
Subjects:	Acids Activities of daily living Aged Aged, 80 and over Aging Alzheimer's disease Alzheimers disease Anatomy & physiology Atrophy Brain Brain - diagnostic imaging Brain - drug effects Brain - metabolism Brain - pathology Clinical trials Cognition Disorders - diagnostic imaging Cognition Disorders - drug therapy Cognition Disorders - metabolism Cognition Disorders - pathology Cognitive ability Consent Cyanocobalamin Dementia Dementia disorders Diet Dietary supplements Disease control Drug dosages Female Folic acid Geriatrics Geriatrics/Dementia Homocysteine Homocysteine - blood Homocysteine - metabolism Humans Impairment Magnetic Resonance Imaging Male Medical treatment Memory Mental Health/Alzheimer Disease Mental Health/Cognitive Neurology Mental Health/Dementia Neurodegenerative diseases Neurological Disorders/Alzheimer Disease Neurological Disorders/Cognitive Neurology and Dementia Neurology NMR Nuclear magnetic resonance Nutrition Older people Pharmacology Physiology Radiography Radiology and Medical Imaging/Magnetic Resonance Imaging Randomization Risk factors Skull Supplementation Treatment Outcome Vitamin B Vitamin B Complex - therapeutic use Vitamin B12 Vitamin B6 Vitamins
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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