Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake

Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) respond to numerous hormonal and neural signals, resulting in changes in food intake. Here, we demonstrate that ARC POMC neurons express capsaicin-sensitive transient receptor potential vanilloid 1 receptor (TRPV1)-l...

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Bibliographic Details
Published in:	PLoS biology Vol. 16; no. 4; p. e2004399
Main Authors:	Jeong, Jae Hoon, Lee, Dong Kun, Liu, Shun-Mei, Chua, Streamson C., Schwartz, Gary J., Jo, Young-Hwan
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 24.04.2018 Public Library of Science (PLoS)
Subjects:	Activation Animals Appetite Arcuate nucleus Arcuate Nucleus of Hypothalamus - cytology Arcuate Nucleus of Hypothalamus - drug effects Arcuate Nucleus of Hypothalamus - metabolism Bacterial Proteins - genetics Bacterial Proteins - metabolism Biology and Life Sciences Body temperature Capsaicin Capsaicin - pharmacology Capsaicin receptors Channelrhodopsins - genetics Channelrhodopsins - metabolism CRISPR Data collection Depolarization Eating - drug effects Eating - genetics Electrophysiology Endocrinology Enhancer Elements, Genetic Enhancers Female Fitness equipment Fluorescence Food Food intake Gene expression Gene Expression Regulation Gene Knock-In Techniques Gene Knockout Techniques Genes, Reporter Hypothalamus Immunohistochemistry Ion channels Luminescent Proteins - genetics Luminescent Proteins - metabolism Male Medicine Medicine and Health Sciences Melanocortin Mice Mice, Transgenic Neural circuitry Neurons Neurons - cytology Neurons - drug effects Neurons - metabolism Optogenetics Physical Conditioning, Animal Physiological aspects Physiology Polymerase chain reaction Pro-Opiomelanocortin - genetics Pro-Opiomelanocortin - metabolism Proopiomelanocortin Proteins Receptors Receptors, Melanocortin - genetics Receptors, Melanocortin - metabolism Research and Analysis Methods Reverse transcription Rodents Running Signal Transduction Single-Cell Analysis Temperature Temperature effects Transient receptor potential proteins TRPV Cation Channels - agonists TRPV Cation Channels - deficiency TRPV Cation Channels - genetics Viruses Weight control Yellow fluorescent protein New York United States > US
ISSN:	1545-7885, 1544-9173, 1545-7885
Online Access:	Get full text
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