A New Pharmacogenetic Algorithm to Predict the Most Appropriate Dosage of Acenocoumarol for Stable Anticoagulation in a Mixed Spanish Population

There is a strong association between genetic polymorphisms and the acenocoumarol dosage requirements. Genotyping the polymorphisms involved in the pharmacokinetics and pharmacodynamics of acenocoumarol before starting anticoagulant therapy would result in a better quality of life and a more efficie...

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Bibliographic Details
Published in:	PLOS ONE Vol. 11; no. 3; p. e0150456
Main Authors:	Cabeza Barrera, José, Dávila-Fajardo, Cristina Lucía, Tong, Hoi Y, Perea León, Laura María, Martínez-González, Luis Javier, Blanco Bañares, María J, Fernández-Capitán, Carmen, Borobia, Alberto M, Lubomirov, Rubin, Díaz-Villamarín, Xando, Carcas, Antonio J
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science (PLoS) 15.03.2016 Public Library of Science
Subjects:	A new algorithm Acenocoumarol Acenocoumarol - administration & dosage Acenocoumarol - pharmacology Acenocoumarol dosage Aged Algorithms Amiodarone Analysis Anticoagulants Anticoagulants - administration & dosage Anticoagulants - pharmacology Appropriate acenocoumarol dosag Biology and Life Sciences Biomedical research Cardiac arrhythmia Dependent variables Dosage Drug dosages Embolisms Farmacia Female Fibrillation Genetic algorithms Genetic polymorphisms Genomics Genotypes Genotyping Health care Humans Independent variables Male Medical Subject Headings::Check Tags::Female Medical Subject Headings::Check Tags::Male Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Hematologic Agents::Anticoagulants Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Benzopyrans::Coumarins::4-Hydroxycoumarins::Acenocoumarol Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Pharmacology::Pharmacogenetics Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans Medical Subject Headings::Phenomena and Processes::Mathematical Concepts::Algorithms Medicina Medicine Medicine and Health Sciences Middle Aged Patients Pharmacodynamics Pharmacogenetic Pharmacogenetics Pharmacokinetics Pharmacology Pharmacy Physical Sciences Q Quality of life R Research and Analysis Methods Research Article Science Spain Stable anticoagulation Thromboembolism Spain
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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