Allergen immunotherapy on the way to product-based evaluation—a WAO statement

Allergen immunotherapy (AIT) is widely used in clinical practice for patients with moderate to severe allergic rhinitis due to inhalant allergens and may be delivered via subcutaneous (SCIT) and sublingual routes (SLIT). However, the quality of evidence for individual AIT products is very heterogene...

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Veröffentlicht in:	The World Allergy Organization journal Jg. 8; H. 1; S. 29 - 4
Hauptverfasser:	Bachert, Claus, Larché, Mark, Bonini, Sergio, Canonica, Giorgio Walter, Kündig, Thomas, Larenas-Linnemann, Desiree, Ledford, Dennis, Neffen, Hugo, Pawankar, Ruby, Passalacqua, Giovanni
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Elsevier Inc 2015 Elsevier BV BioMed Central BioMed Central Ltd Elsevier
Schlagworte:	Allergens Allergies Allergology Analysis Asthma Care and treatment EUROPE Evidence-based medicine Health aspects Immunologic diseases. Allergy Immunology Immunology and Allergy Immunotherapy Medical colleges Medicine Medicine & Public Health Medicine and Health Sciences ORGANIZATION Position and Guidelines Position Article and Guidelines RANDOMIZED CONTROLLED-TRIAL RC581-607 RECOMMENDATIONS RHINOCONJUNCTIVITIS STANDARDIZATION Allergic Rhinitis Individual Product Allergen Immunotherapy Allergen Extract Inhalant Allergen
ISSN:	1939-4551, 1939-4551
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Abstract	Allergen immunotherapy (AIT) is widely used in clinical practice for patients with moderate to severe allergic rhinitis due to inhalant allergens and may be delivered via subcutaneous (SCIT) and sublingual routes (SLIT). However, the quality of evidence for individual AIT products is very heterogeneous, and extensions of overall conclusions (“class effects”) on the efficacy and disease-modifying effects to all AIT products are unjustified. In contrast, each product needs to be evaluated individually, based on available study results, to justify efficacy and specific claims on sustained and disease modifying effects per allergen and targeted patient group (children vs. adults, allergic rhinitis vs. asthma). WAO intends to support the current development to evidence-based AIT, which ultimately will lead to a more efficacious treatment of allergic patients and the appropriate recognition of AIT.
AbstractList	Allergen immunotherapy (AIT) is widely used in clinical practice for patients with moderate to severe allergic rhinitis due to inhalant allergens and may be delivered via subcutaneous (SCIT) and sublingual routes (SLIT). However, the quality of evidence for individual AIT products is very heterogeneous, and extensions of overall conclusions (“class effects”) on the efficacy and disease-modifying effects to all AIT products are unjustified. In contrast, each product needs to be evaluated individually, based on available study results, to justify efficacy and specific claims on sustained and disease modifying effects per allergen and targeted patient group (children vs. adults, allergic rhinitis vs. asthma). WAO intends to support the current development to evidence-based AIT, which ultimately will lead to a more efficacious treatment of allergic patients and the appropriate recognition of AIT. Allergen immunotherapy (AIT) is widely used in clinical practice for patients with moderate to severe allergic rhinitis due to inhalant allergens and may be delivered via subcutaneous (SCIT) and sublingual routes (SLIT). However, the quality of evidence for individual AIT products is very heterogeneous, and extensions of overall conclusions ("class effects") on the efficacy and disease-modifying effects to all AIT products are unjustified. In contrast, each product needs to be evaluated individually, based on available study results, to justify efficacy and specific claims on sustained and disease modifying effects per allergen and targeted patient group (children vs. adults, allergic rhinitis vs. asthma). WAO intends to support the current development to evidence-based AIT, which ultimately will lead to a more efficacious treatment of allergic patients and the appropriate recognition of AIT.Allergen immunotherapy (AIT) is widely used in clinical practice for patients with moderate to severe allergic rhinitis due to inhalant allergens and may be delivered via subcutaneous (SCIT) and sublingual routes (SLIT). However, the quality of evidence for individual AIT products is very heterogeneous, and extensions of overall conclusions ("class effects") on the efficacy and disease-modifying effects to all AIT products are unjustified. In contrast, each product needs to be evaluated individually, based on available study results, to justify efficacy and specific claims on sustained and disease modifying effects per allergen and targeted patient group (children vs. adults, allergic rhinitis vs. asthma). WAO intends to support the current development to evidence-based AIT, which ultimately will lead to a more efficacious treatment of allergic patients and the appropriate recognition of AIT.
ArticleNumber	29
Audience	Academic
Author	Passalacqua, Giovanni Larenas-Linnemann, Desiree Bachert, Claus Bonini, Sergio Canonica, Giorgio Walter Pawankar, Ruby Neffen, Hugo Larché, Mark Kündig, Thomas Ledford, Dennis
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Keywords	Allergic Rhinitis Individual Product Allergen Immunotherapy Allergen Extract Inhalant Allergen
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SubjectTerms	Allergens Allergies Allergology Analysis Asthma Care and treatment EUROPE Evidence-based medicine Health aspects Immunologic diseases. Allergy Immunology Immunology and Allergy Immunotherapy Medical colleges Medicine Medicine & Public Health Medicine and Health Sciences ORGANIZATION Position and Guidelines Position Article and Guidelines RANDOMIZED CONTROLLED-TRIAL RC581-607 RECOMMENDATIONS RHINOCONJUNCTIVITIS STANDARDIZATION
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Title	Allergen immunotherapy on the way to product-based evaluation—a WAO statement
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