Optogenetic self-stimulation in the nucleus accumbens: D1 reward versus D2 ambivalence

The nucleus accumbens (NAc) contains multiple subpopulations of medium spiny neurons (MSNs). One subpopulation expresses D1-type dopamine receptors, another expresses D2-type receptors, and a third expresses both. The relative roles in NAc of D1 neurons versus D2 neurons in appetitive motivation wer...

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Bibliographic Details
Published in:	PloS one Vol. 13; no. 11; p. e0207694
Main Authors:	Cole, Shannon L., Robinson, Mike J. F., Berridge, Kent C.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 29.11.2018 Public Library of Science (PLoS)
Subjects:	Analysis Animal behavior Animals Biology and Life Sciences Brain Cocaine Dopamine Dopamine D1 receptors Dopamine D2 receptors Dopamine receptors Engineering and Technology Excitation Female Females Fiber optics Food Hypotheses Internet Laboratory animals Lasers Male Males Medicine and Health Sciences Membrane proteins Mice Mice, Inbred C57BL Mice, Transgenic Motivation Neurons Neurosciences Nucleus accumbens Nucleus Accumbens - metabolism Nucleus Accumbens - pathology Optical fibers Optogenetics Phenols (Class of compounds) Photomicrography Receptors Receptors, Dopamine D1 - genetics Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - genetics Receptors, Dopamine D2 - metabolism Reinforcement Research and Analysis Methods Rodents Self stimulation Social Sciences Spiny neurons Subpopulations Transgenic animals Viruses United States > US
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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