Protease Activated Receptors 1 and 2 Correlate Differently with Breast Cancer Aggressiveness Depending on Tumor ER Status

Experimental models implicate protease activated receptors (PARs) as important sensors of the proteolytic tumor microenvironment during breast cancer development. However, the role of the major PARs, PAR-1 and PAR-2, in human breast tumors remains to be elucidated. Here, we have investigated how PAR...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 8; p. e0134932
Main Authors:	Lidfeldt, Jon, Bendahl, Pär-Ola, Forsare, Carina, Malmström, Per, Fernö, Mårten, Belting, Mattias
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 05.08.2015 Public Library of Science (PLoS)
Subjects:	Adult Analysis Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer and Oncology Cancer och onkologi Cancer therapies Care and treatment Clinical Medicine Cohort Studies Correlation Development and progression Diagnosis Endocrinology Female Gene expression Growth factors Hazards Humans Immunohistochemistry - statistics & numerical data Kaplan-Meier Estimate Kinases Klinisk medicin Lymphatic system Matrix metalloproteinase inhibitors Medical and Health Sciences Medical prognosis Medicin och hälsovetenskap Metastasis Middle Aged Oncology Par-2 protein Pathology Patients Prognosis Proportional Hazards Models Protease Proteases Proteinase Proteinase-activated receptor 1 Proteins Proteolysis Rank tests Receptor, PAR-1 - metabolism Receptor, PAR-2 - metabolism Receptors Receptors, Estrogen - metabolism Risk factors Signal Transduction Statistical models Studies Survival Tissue Array Analysis - statistics & numerical data Tumors Sweden
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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