Three-way interactions between mosquito population, viral strain and temperature underlying chikungunya virus transmission potential

Interactions between pathogens and their insect vectors in nature are under the control of both genetic and non-genetic factors, yet most studies on mosquito vector competence for human pathogens are conducted in laboratory systems that do not consider genetic and/or environmental variability. Evalu...

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Published in:Proceedings of the Royal Society. B, Biological sciences Vol. 281; no. 1792
Main Authors: Zouache, Karima, Fontaine, Albin, Vega-Rua, Anubis, Mousson, Laurence, Thiberge, Jean-Michel, Lourenco-De-Oliveira, Ricardo, Caro, Valérie, Lambrechts, Louis, Failloux, Anna-Bella
Format: Journal Article
Language:English
Published: England 07.10.2014
Subjects:
Aedes - genetics
Aedes - virology
Alphavirus Infections - transmission
Animals
Chikungunya virus - genetics
Genotype
Insect Vectors - genetics
Insect Vectors - virology
Mice
Temperature
interaction
temperature
transmission
chikungunya
arbovirus
mosquito
ISSN:1471-2954, 1471-2954
Online Access:Get more information
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Summary:Interactions between pathogens and their insect vectors in nature are under the control of both genetic and non-genetic factors, yet most studies on mosquito vector competence for human pathogens are conducted in laboratory systems that do not consider genetic and/or environmental variability. Evaluating the risk of emergence of arthropod-borne viruses (arboviruses) of public health importance such as chikungunya virus (CHIKV) requires a more realistic appraisal of genetic and environmental contributions to vector competence. In particular, sources of variation do not necessarily act independently and may combine in the form of interactions. Here, we measured CHIKV transmission potential by the mosquito Aedes albopictus in all combinations of six worldwide vector populations, two virus strains and two ambient temperatures (20°C and 28°C). Overall, CHIKV transmission potential by Ae. albopictus strongly depended on the three-way combination of mosquito population, virus strain and temperature. Such genotype-by-genotype-by-environment (G × G × E) interactions question the relevance of vector competence studies conducted with a simpler set of conditions. Our results highlight the need to account for the complex interplay between vectors, pathogens and environmental factors to accurately assess the potential of vector-borne diseases to emerge.
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ISSN:1471-2954
1471-2954
DOI:10.1098/rspb.2014.1078