Three-way interactions between mosquito population, viral strain and temperature underlying chikungunya virus transmission potential
Interactions between pathogens and their insect vectors in nature are under the control of both genetic and non-genetic factors, yet most studies on mosquito vector competence for human pathogens are conducted in laboratory systems that do not consider genetic and/or environmental variability. Evalu...
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| Published in: | Proceedings of the Royal Society. B, Biological sciences Vol. 281; no. 1792 |
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| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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England
07.10.2014
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| ISSN: | 1471-2954, 1471-2954 |
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| Abstract | Interactions between pathogens and their insect vectors in nature are under the control of both genetic and non-genetic factors, yet most studies on mosquito vector competence for human pathogens are conducted in laboratory systems that do not consider genetic and/or environmental variability. Evaluating the risk of emergence of arthropod-borne viruses (arboviruses) of public health importance such as chikungunya virus (CHIKV) requires a more realistic appraisal of genetic and environmental contributions to vector competence. In particular, sources of variation do not necessarily act independently and may combine in the form of interactions. Here, we measured CHIKV transmission potential by the mosquito Aedes albopictus in all combinations of six worldwide vector populations, two virus strains and two ambient temperatures (20°C and 28°C). Overall, CHIKV transmission potential by Ae. albopictus strongly depended on the three-way combination of mosquito population, virus strain and temperature. Such genotype-by-genotype-by-environment (G × G × E) interactions question the relevance of vector competence studies conducted with a simpler set of conditions. Our results highlight the need to account for the complex interplay between vectors, pathogens and environmental factors to accurately assess the potential of vector-borne diseases to emerge. |
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| AbstractList | Interactions between pathogens and their insect vectors in nature are under the control of both genetic and non-genetic factors, yet most studies on mosquito vector competence for human pathogens are conducted in laboratory systems that do not consider genetic and/or environmental variability. Evaluating the risk of emergence of arthropod-borne viruses (arboviruses) of public health importance such as chikungunya virus (CHIKV) requires a more realistic appraisal of genetic and environmental contributions to vector competence. In particular, sources of variation do not necessarily act independently and may combine in the form of interactions. Here, we measured CHIKV transmission potential by the mosquito Aedes albopictus in all combinations of six worldwide vector populations, two virus strains and two ambient temperatures (20°C and 28°C). Overall, CHIKV transmission potential by Ae. albopictus strongly depended on the three-way combination of mosquito population, virus strain and temperature. Such genotype-by-genotype-by-environment (G × G × E) interactions question the relevance of vector competence studies conducted with a simpler set of conditions. Our results highlight the need to account for the complex interplay between vectors, pathogens and environmental factors to accurately assess the potential of vector-borne diseases to emerge.Interactions between pathogens and their insect vectors in nature are under the control of both genetic and non-genetic factors, yet most studies on mosquito vector competence for human pathogens are conducted in laboratory systems that do not consider genetic and/or environmental variability. Evaluating the risk of emergence of arthropod-borne viruses (arboviruses) of public health importance such as chikungunya virus (CHIKV) requires a more realistic appraisal of genetic and environmental contributions to vector competence. In particular, sources of variation do not necessarily act independently and may combine in the form of interactions. Here, we measured CHIKV transmission potential by the mosquito Aedes albopictus in all combinations of six worldwide vector populations, two virus strains and two ambient temperatures (20°C and 28°C). Overall, CHIKV transmission potential by Ae. albopictus strongly depended on the three-way combination of mosquito population, virus strain and temperature. Such genotype-by-genotype-by-environment (G × G × E) interactions question the relevance of vector competence studies conducted with a simpler set of conditions. Our results highlight the need to account for the complex interplay between vectors, pathogens and environmental factors to accurately assess the potential of vector-borne diseases to emerge. Interactions between pathogens and their insect vectors in nature are under the control of both genetic and non-genetic factors, yet most studies on mosquito vector competence for human pathogens are conducted in laboratory systems that do not consider genetic and/or environmental variability. Evaluating the risk of emergence of arthropod-borne viruses (arboviruses) of public health importance such as chikungunya virus (CHIKV) requires a more realistic appraisal of genetic and environmental contributions to vector competence. In particular, sources of variation do not necessarily act independently and may combine in the form of interactions. Here, we measured CHIKV transmission potential by the mosquito Aedes albopictus in all combinations of six worldwide vector populations, two virus strains and two ambient temperatures (20°C and 28°C). Overall, CHIKV transmission potential by Ae. albopictus strongly depended on the three-way combination of mosquito population, virus strain and temperature. Such genotype-by-genotype-by-environment (G × G × E) interactions question the relevance of vector competence studies conducted with a simpler set of conditions. Our results highlight the need to account for the complex interplay between vectors, pathogens and environmental factors to accurately assess the potential of vector-borne diseases to emerge. |
| Author | Failloux, Anna-Bella Lambrechts, Louis Fontaine, Albin Mousson, Laurence Caro, Valérie Vega-Rua, Anubis Zouache, Karima Thiberge, Jean-Michel Lourenco-De-Oliveira, Ricardo |
| Author_xml | – sequence: 1 givenname: Karima surname: Zouache fullname: Zouache, Karima email: karima.zouache@pasteur.fr organization: Department of Virology, Institut Pasteur, Arboviruses and Insect Vectors Laboratory, Paris, France karima.zouache@pasteur.fr – sequence: 2 givenname: Albin surname: Fontaine fullname: Fontaine, Albin organization: Department of Genomes and Genetics, Institut Pasteur-Centre National de la Recherche Scientifique URA 3012, Insect-Virus Interactions Group, Paris, France Institut de Recherche Biomédicale des Armées (IRBA), Unité d'Entomologie, Brétigny-sur-Orge, France – sequence: 3 givenname: Anubis surname: Vega-Rua fullname: Vega-Rua, Anubis organization: Department of Virology, Institut Pasteur, Arboviruses and Insect Vectors Laboratory, Paris, France Université Pierre et Marie Curie, Cellule Pasteur UPMC, Paris, France – sequence: 4 givenname: Laurence surname: Mousson fullname: Mousson, Laurence organization: Department of Virology, Institut Pasteur, Arboviruses and Insect Vectors Laboratory, Paris, France – sequence: 5 givenname: Jean-Michel surname: Thiberge fullname: Thiberge, Jean-Michel organization: Institut Pasteur, Genotyping of Pathogens and Public Health, Paris, France – sequence: 6 givenname: Ricardo surname: Lourenco-De-Oliveira fullname: Lourenco-De-Oliveira, Ricardo organization: Department of Virology, Institut Pasteur, Arboviruses and Insect Vectors Laboratory, Paris, France Laboratório de Transmissores de Hematozoários, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil – sequence: 7 givenname: Valérie surname: Caro fullname: Caro, Valérie organization: Institut Pasteur, Genotyping of Pathogens and Public Health, Paris, France – sequence: 8 givenname: Louis surname: Lambrechts fullname: Lambrechts, Louis organization: Department of Genomes and Genetics, Institut Pasteur-Centre National de la Recherche Scientifique URA 3012, Insect-Virus Interactions Group, Paris, France – sequence: 9 givenname: Anna-Bella surname: Failloux fullname: Failloux, Anna-Bella organization: Department of Virology, Institut Pasteur, Arboviruses and Insect Vectors Laboratory, Paris, France |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25122228$$D View this record in MEDLINE/PubMed |
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| Title | Three-way interactions between mosquito population, viral strain and temperature underlying chikungunya virus transmission potential |
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