ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity

Group 2 innate lymphoid cells (ILC2s) regulate inflammation and immunity in mammalian tissues 1 , 2 . Although ILC2s are found in cancers of these tissues 3 , their roles in cancer immunity and immunotherapy are unclear. Here we show that ILC2s infiltrate pancreatic ductal adenocarcinomas (PDACs) to...

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Bibliographic Details
Published in:	Nature (London) Vol. 579; no. 7797; pp. 130 - 135
Main Authors:	Moral, John Alec, Leung, Joanne, Rojas, Luis A., Ruan, Jennifer, Zhao, Julia, Sethna, Zachary, Ramnarain, Anita, Gasmi, Billel, Gururajan, Murali, Redmond, David, Askan, Gokce, Bhanot, Umesh, Elyada, Ela, Park, Youngkyu, Tuveson, David A., Gönen, Mithat, Leach, Steven D., Wolchok, Jedd D., DeMatteo, Ronald P., Merghoub, Taha, Balachandran, Vinod P.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 05.03.2020 Nature Publishing Group
Subjects:	13/1 13/106 13/31 13/51 38/39 38/91 631/250/2504 631/67/1504/1713 631/67/580 64/60 Analysis Animals Anticancer properties Antigen processing Antigens Apoptotic proteins Cancer Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - immunology Care and treatment CD45 antigen CD90 antigen Cell activation Cellular immunity Control Cytokines Dendritic Cells - immunology Euthanasia Female Gene sequencing Genotype & phenotype Humanities and Social Sciences Humans Immune system Immunity Immunity, Innate - immunology Immunotherapy Interleukin-33 - immunology Lymphatic system Lymphocyte Activation Lymphocytes Lymphocytes - immunology Lymphocytes T Major histocompatibility complex Male Mice Mice, Inbred C57BL multidisciplinary Organs Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - immunology Patient outcomes PD-1 protein Physiological aspects Priming Programmed Cell Death 1 Receptor - antagonists & inhibitors Ribonucleic acid RNA Science Science (multidisciplinary) T-Lymphocytes - immunology Transcription Tumor-infiltrating lymphocytes Tumors United States
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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