Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states

ABCG2 is a transporter protein of the ATP-binding-cassette (ABC) family that is expressed in the plasma membrane in cells of various tissues and tissue barriers, including the blood–brain, blood–testis and maternal–fetal barriers 1 – 4 . Powered by ATP, it translocates endogenous substrates, affects...

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Veröffentlicht in:	Nature (London) Jg. 563; H. 7731; S. 426 - 430
Hauptverfasser:	Manolaridis, Ioannis, Jackson, Scott M., Taylor, Nicholas M. I., Kowal, Julia, Stahlberg, Henning, Locher, Kaspar P.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.11.2018 Nature Publishing Group
Schlagworte:	101/28 631/45/535/1258/1259 631/45/612/1237 631/535/1258/1259 82 ABC transporters Adenosine triphosphatase Adenosine triphosphate Adenosine Triphosphate - metabolism Antibodies ATP Binding Cassette Transporter, Subfamily G, Member 2 - chemistry ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism ATP Binding Cassette Transporter, Subfamily G, Member 2 - ultrastructure ATPases Binding Binding Sites Blood Brain Cancer Cancer research Cancer treatment Catalysis Cell membranes Cryoelectron Microscopy Cytoplasm Domains Electron microscopy Estrone Fetuses Glutamate Glutamine Humanities and Social Sciences Humans Hydrogen bonds Hydrophobicity Letter Leucine Ligands Microscopy Models, Molecular multidisciplinary Mutagenesis Mutant Proteins - chemistry Mutant Proteins - genetics Mutant Proteins - metabolism Mutant Proteins - ultrastructure Mutation Neoplasm Proteins - chemistry Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasm Proteins - ultrastructure Pharmacokinetics Pharmacology Physiological aspects Protein Binding Protein Conformation Protein transport Proteins Recognition Science Science (multidisciplinary) Substrate inhibition Substrate Specificity Substrates Sulfates Symmetry Translocation Transmembrane domains Transport Transport proteins Xenobiotics United States > US Human ABCG2 Substrate-bound State Substrate-binding Cavity Nucleotide-binding Domain (NBD) External Cavity
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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