Structures and distributions of SARS-CoV-2 spike proteins on intact virions

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virions are surrounded by a lipid bilayer from which spike (S) protein trimers protrude 1 . Heavily glycosylated S trimers bind to the angiotensin-converting enzyme 2 receptor and mediate entry of virions into target cells 2 – 6 . S exhibi...

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Bibliographic Details
Published in:	Nature (London) Vol. 588; no. 7838; pp. 498 - 502
Main Authors:	Ke, Zunlong, Oton, Joaquin, Qu, Kun, Cortese, Mirko, Zila, Vojtech, McKeane, Lesley, Nakane, Takanori, Zivanov, Jasenko, Neufeldt, Christopher J., Cerikan, Berati, Lu, John M., Peukes, Julia, Xiong, Xiaoli, Kräusslich, Hans-Georg, Scheres, Sjors H. W., Bartenschlager, Ralf, Briggs, John A. G.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 17.12.2020 Nature Publishing Group
Subjects:	101/28 631/326/596/4130 631/535/1258/1259 631/535/1258/1260 Antibodies Antibodies, Neutralizing - immunology Binding sites Cell Line, Tumor Coronaviruses COVID-19 - immunology COVID-19 Vaccines - immunology Cryoelectron Microscopy Distribution Electron microscopy Endoplasmic reticulum Enzymes Flexibility Humanities and Social Sciences Humans Infections Lipid bilayers Lipids Microscopy Models, Molecular Monomers multidisciplinary Peptides Physiological aspects Pliability Protein Conformation Protein Multimerization Protein S Protein structure Proteins SARS-CoV-2 - chemistry SARS-CoV-2 - isolation & purification SARS-CoV-2 - metabolism SARS-CoV-2 - ultrastructure Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - analysis Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - isolation & purification Spike Glycoprotein, Coronavirus - ultrastructure Structure Tomography Transmission electron microscopy Trimers Virion - chemistry Virion - isolation & purification Virion - metabolism Virion - ultrastructure Virions Viroplasm Virus research United Kingdom
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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