MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker Discovery study

Background With the shift of research focus towards the pre-dementia stage of Alzheimer’s disease (AD), there is an urgent need for reliable, non-invasive biomarkers to predict amyloid pathology. The aim of this study was to assess whether easily obtainable measures from structural MRI, combined wit...

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Published in:	Alzheimer's research & therapy Vol. 10; no. 1; pp. 100 - 12
Main Authors:	ten Kate, Mara, Redolfi, Alberto, Peira, Enrico, Bos, Isabelle, Vos, Stephanie J., Vandenberghe, Rik, Gabel, Silvy, Schaeverbeke, Jolien, Scheltens, Philip, Blin, Olivier, Richardson, Jill C., Bordet, Regis, Wallin, Anders, Eckerstrom, Carl, Molinuevo, José Luis, Engelborghs, Sebastiaan, Van Broeckhoven, Christine, Martinez-Lage, Pablo, Popp, Julius, Tsolaki, Magdalini, Verhey, Frans R. J., Baird, Alison L., Legido-Quigley, Cristina, Bertram, Lars, Dobricic, Valerija, Zetterberg, Henrik, Lovestone, Simon, Streffer, Johannes, Bianchetti, Silvia, Novak, Gerald P., Revillard, Jerome, Gordon, Mark F., Xie, Zhiyong, Wottschel, Viktor, Frisoni, Giovanni, Visser, Pieter Jelle, Barkhof, Frederik
Format:	Journal Article
Language:	English
Published:	London BioMed Central 27.09.2018 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Age Aged Alzheimer Disease - diagnostic imaging Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease alzheimers-disease Amyloid Amyloid beta-Peptides - cerebrospinal fluid Amyloid beta-Peptides - metabolism Analysis Apolipoprotein E4 - genetics Apolipoproteins Artificial intelligence atrophy Automation beta deposition Biomarkers Biomedical and Life Sciences Biomedicine Brain - diagnostic imaging Brain - pathology Brain research Clinical trials Cognition & reasoning Cognitive ability Cognitive Dysfunction - diagnostic imaging Cognitive Dysfunction - pathology Cognitive science Dementia Diagnosis Female Geriatric Psychiatry Geriatrics/Gerontology Glycoproteins Humans Internet machine Machine learning Magnetic Resonance Imaging Male Medical imaging Middle Aged Mild cognitive impairment Neurology Neuroscience Neurosciences Neurovetenskaper NMR Nuclear magnetic resonance Pathology Positron emission tomography prevention ROC Curve selection bias Support Vector Machine Alzheimer’s disease Magnetic resonance imaging European Medical Information Framework for Alzheimer’s Disease Mild cognitive impairment Machine learning Biomarkers Amyloid Support vector machine
ISSN:	1758-9193, 1758-9193
Online Access:	Get full text
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