Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data

Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then co...

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Vydáno v:	Nature communications Ročník 10; číslo 1; s. 2773 - 13
Hlavní autoři:	Shungin, Dmitry, Haworth, Simon, Divaris, Kimon, Agler, Cary S., Kamatani, Yoichiro, Keun Lee, Myoung, Grinde, Kelsey, Hindy, George, Alaraudanjoki, Viivi, Pesonen, Paula, Teumer, Alexander, Holtfreter, Birte, Sakaue, Saori, Hirata, Jun, Yu, Yau-Hua, Ridker, Paul M., Giulianini, Franco, Chasman, Daniel I., Magnusson, Patrik K. E., Sudo, Takeaki, Okada, Yukinori, Völker, Uwe, Kocher, Thomas, Anttonen, Vuokko, Laitala, Marja-Liisa, Orho-Melander, Marju, Sofer, Tamar, Shaffer, John R., Vieira, Alexandre, Marazita, Mary L., Kubo, Michiaki, Furuichi, Yasushi, North, Kari E., Offenbacher, Steve, Ingelsson, Erik, Franks, Paul W., Timpson, Nicholas J., Johansson, Ingegerd
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 24.06.2019 Nature Publishing Group Nature Portfolio
Témata:	45/43 631/208/1516 631/208/205/2138 692/308/174 692/699/3020 Basic Medicine Clinical Medicine Dental caries Dental Caries - epidemiology Dental Caries - genetics Dental disorders Downstream effects Fluoridation Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Genomics Gum disease Heredity Heritability Humanities and Social Sciences Humans Klinisk medicin Medical and Health Sciences Medical Genetics and Genomics (including Gene Therapy) Medicin och hälsovetenskap Medicinsk genetik och genomik (Här ingår: Genterapi) Medicinska och farmaceutiska grundvetenskaper Mendelian Randomization Analysis Metabolism Morbidity multidisciplinary Odontologi Odontology Periodontitis Periodontitis - epidemiology Periodontitis - genetics Polymorphism, Single Nucleotide Quantitative Trait Loci - genetics Science Science (multidisciplinary) Self Report - statistics & numerical data Smoking
ISSN:	2041-1723, 2041-1723
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Shrnutí:	Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health. Dental caries and periodontitis are among the most common medical conditions. Here, the authors report a GWAS for measures of oral health that reveals 47 risk loci for caries, find genetic correlation with 31 other complex traits and use Mendelian randomization analyses to explore potential causal relationships.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-019-10630-1