Systematic underestimation of the epigenetic clock and age acceleration in older subjects

Background The Horvath epigenetic clock is widely used. It predicts age quite well from 353 CpG sites in the DNA methylation profile in unknown samples and has been used to calculate “age acceleration” in various tissues and environments. Results The model systematically underestimates age in tissue...

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Bibliographic Details
Published in:	Genome Biology Vol. 20; no. 1; p. 283
Main Authors:	El Khoury, Louis Y., Gorrie-Stone, Tyler, Smart, Melissa, Hughes, Amanda, Bao, Yanchun, Andrayas, Alexandria, Burrage, Joe, Hannon, Eilis, Kumari, Meena, Mill, Jonathan, Schalkwyk, Leonard C.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 17.12.2019 Springer Nature B.V BMC
Subjects:	Age Age acceleration Aging - genetics Animal Genetics and Genomics Bioinformatics Biological Clocks Biomedical and Life Sciences Blood Cerebellum CpG islands data collection Datasets Deoxyribonucleic acid DNA DNA methylation Epigenesis, Genetic Epigenetic clock Epigenetics Evolutionary Biology Genetic testing genome Human Genetics Humans Life Sciences Microbial Genetics and Genomics people Plant Genetics and Genomics DNA methylation Age acceleration Epigenetic clock
ISSN:	1474-760X, 1474-7596, 1474-760X
Online Access:	Get full text
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