Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression
Single-cell RNA-seq (scRNA-seq) data exhibits significant cell-to-cell variation due to technical factors, including the number of molecules detected in each cell, which can confound biological heterogeneity with technical effects. To address this, we present a modeling framework for the normalizati...
Uložené v:
| Vydané v: | Genome Biology Ročník 20; číslo 1; s. 296 |
|---|---|
| Hlavní autori: | , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
London
BioMed Central
23.12.2019
Springer Nature B.V BMC |
| Predmet: | |
| ISSN: | 1474-760X, 1474-7596, 1474-760X |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Single-cell RNA-seq (scRNA-seq) data exhibits significant cell-to-cell variation due to technical factors, including the number of molecules detected in each cell, which can confound biological heterogeneity with technical effects. To address this, we present a modeling framework for the normalization and variance stabilization of molecular count data from scRNA-seq experiments. We propose that the Pearson residuals from “regularized negative binomial regression,” where cellular sequencing depth is utilized as a covariate in a generalized linear model, successfully remove the influence of technical characteristics from downstream analyses while preserving biological heterogeneity. Importantly, we show that an unconstrained negative binomial model may overfit scRNA-seq data, and overcome this by pooling information across genes with similar abundances to obtain stable parameter estimates. Our procedure omits the need for heuristic steps including pseudocount addition or log-transformation and improves common downstream analytical tasks such as variable gene selection, dimensional reduction, and differential expression. Our approach can be applied to any UMI-based scRNA-seq dataset and is freely available as part of the R package
sctransform
, with a direct interface to our single-cell toolkit
Seurat
. |
|---|---|
| AbstractList | Abstract Single-cell RNA-seq (scRNA-seq) data exhibits significant cell-to-cell variation due to technical factors, including the number of molecules detected in each cell, which can confound biological heterogeneity with technical effects. To address this, we present a modeling framework for the normalization and variance stabilization of molecular count data from scRNA-seq experiments. We propose that the Pearson residuals from “regularized negative binomial regression,” where cellular sequencing depth is utilized as a covariate in a generalized linear model, successfully remove the influence of technical characteristics from downstream analyses while preserving biological heterogeneity. Importantly, we show that an unconstrained negative binomial model may overfit scRNA-seq data, and overcome this by pooling information across genes with similar abundances to obtain stable parameter estimates. Our procedure omits the need for heuristic steps including pseudocount addition or log-transformation and improves common downstream analytical tasks such as variable gene selection, dimensional reduction, and differential expression. Our approach can be applied to any UMI-based scRNA-seq dataset and is freely available as part of the R package sctransform, with a direct interface to our single-cell toolkit Seurat. Single-cell RNA-seq (scRNA-seq) data exhibits significant cell-to-cell variation due to technical factors, including the number of molecules detected in each cell, which can confound biological heterogeneity with technical effects. To address this, we present a modeling framework for the normalization and variance stabilization of molecular count data from scRNA-seq experiments. We propose that the Pearson residuals from “regularized negative binomial regression,” where cellular sequencing depth is utilized as a covariate in a generalized linear model, successfully remove the influence of technical characteristics from downstream analyses while preserving biological heterogeneity. Importantly, we show that an unconstrained negative binomial model may overfit scRNA-seq data, and overcome this by pooling information across genes with similar abundances to obtain stable parameter estimates. Our procedure omits the need for heuristic steps including pseudocount addition or log-transformation and improves common downstream analytical tasks such as variable gene selection, dimensional reduction, and differential expression. Our approach can be applied to any UMI-based scRNA-seq dataset and is freely available as part of the R package sctransform, with a direct interface to our single-cell toolkit Seurat. Single-cell RNA-seq (scRNA-seq) data exhibits significant cell-to-cell variation due to technical factors, including the number of molecules detected in each cell, which can confound biological heterogeneity with technical effects. To address this, we present a modeling framework for the normalization and variance stabilization of molecular count data from scRNA-seq experiments. We propose that the Pearson residuals from “regularized negative binomial regression,” where cellular sequencing depth is utilized as a covariate in a generalized linear model, successfully remove the influence of technical characteristics from downstream analyses while preserving biological heterogeneity. Importantly, we show that an unconstrained negative binomial model may overfit scRNA-seq data, and overcome this by pooling information across genes with similar abundances to obtain stable parameter estimates. Our procedure omits the need for heuristic steps including pseudocount addition or log-transformation and improves common downstream analytical tasks such as variable gene selection, dimensional reduction, and differential expression. Our approach can be applied to any UMI-based scRNA-seq dataset and is freely available as part of the R package sctransform , with a direct interface to our single-cell toolkit Seurat . Single-cell RNA-seq (scRNA-seq) data exhibits significant cell-to-cell variation due to technical factors, including the number of molecules detected in each cell, which can confound biological heterogeneity with technical effects. To address this, we present a modeling framework for the normalization and variance stabilization of molecular count data from scRNA-seq experiments. We propose that the Pearson residuals from "regularized negative binomial regression," where cellular sequencing depth is utilized as a covariate in a generalized linear model, successfully remove the influence of technical characteristics from downstream analyses while preserving biological heterogeneity. Importantly, we show that an unconstrained negative binomial model may overfit scRNA-seq data, and overcome this by pooling information across genes with similar abundances to obtain stable parameter estimates. Our procedure omits the need for heuristic steps including pseudocount addition or log-transformation and improves common downstream analytical tasks such as variable gene selection, dimensional reduction, and differential expression. Our approach can be applied to any UMI-based scRNA-seq dataset and is freely available as part of the R package sctransform, with a direct interface to our single-cell toolkit Seurat.Single-cell RNA-seq (scRNA-seq) data exhibits significant cell-to-cell variation due to technical factors, including the number of molecules detected in each cell, which can confound biological heterogeneity with technical effects. To address this, we present a modeling framework for the normalization and variance stabilization of molecular count data from scRNA-seq experiments. We propose that the Pearson residuals from "regularized negative binomial regression," where cellular sequencing depth is utilized as a covariate in a generalized linear model, successfully remove the influence of technical characteristics from downstream analyses while preserving biological heterogeneity. Importantly, we show that an unconstrained negative binomial model may overfit scRNA-seq data, and overcome this by pooling information across genes with similar abundances to obtain stable parameter estimates. Our procedure omits the need for heuristic steps including pseudocount addition or log-transformation and improves common downstream analytical tasks such as variable gene selection, dimensional reduction, and differential expression. Our approach can be applied to any UMI-based scRNA-seq dataset and is freely available as part of the R package sctransform, with a direct interface to our single-cell toolkit Seurat. Single-cell RNA-seq (scRNA-seq) data exhibits significant cell-to-cell variation due to technical factors, including the number of molecules detected in each cell, which can confound biological heterogeneity with technical effects. To address this, we present a modeling framework for the normalization and variance stabilization of molecular count data from scRNA-seq experiments. We propose that the Pearson residuals from “regularized negative binomial regression,” where cellular sequencing depth is utilized as a covariate in a generalized linear model, successfully remove the influence of technical characteristics from downstream analyses while preserving biological heterogeneity. Importantly, we show that an unconstrained negative binomial model may overfit scRNA-seq data, and overcome this by pooling information across genes with similar abundances to obtain stable parameter estimates. Our procedure omits the need for heuristic steps including pseudocount addition or log-transformation and improves common downstream analytical tasks such as variable gene selection, dimensional reduction, and differential expression. Our approach can be applied to any UMI-based scRNA-seq dataset and is freely available as part of the R package , with a direct interface to our single-cell toolkit . |
| ArticleNumber | 296 |
| Author | Hafemeister, Christoph Satija, Rahul |
| Author_xml | – sequence: 1 givenname: Christoph surname: Hafemeister fullname: Hafemeister, Christoph email: christoph.hafemeister@nyu.edu organization: New York Genome Center – sequence: 2 givenname: Rahul orcidid: 0000-0001-9448-8833 surname: Satija fullname: Satija, Rahul email: rsatija@nygenome.org organization: New York Genome Center, Center for Genomics and Systems Biology, New York University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31870423$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkktv1TAQhSNURB_wA9igSGzYBOzYiZ0NUlXxqFQVCXXBzhrbk-CrxG7t5Er01-P0tqWtBKxsec75PB6fw2LPB49F8ZqS95TK9kOijDRdRWhXUSl4RZ8VB5TnjWjJj70H-_3iMKUNyUJety-KfZblhNfsoEjnIU4wumuYXfAleFtuITrwBss0g3b3pdCXyflhxMrgOJbfz4-rhFelhRnKZa2UEYdlzOZrtKXHIdu2WGrnw-RgXKsRU8qol8XzHsaEr27Xo-Li86eLk6_V2bcvpyfHZ5URgsyVaWXT16S3kmuQne0kYx2AkMxa0DURxvCmsUbq3oIE1LVlvW162WEjWcOOitMd1gbYqMvoJoi_VACnbg5CHBTE2ZkRVau1xL5Bpg3npkXJEbTpe0EbLbhhmfVxx7pc9ITWoJ8jjI-gjyve_VRD2Kq2qwWVNAPe3QJiuFowzWpyaR0keAxLUjUXomU167r_SxkjjFHStVn69ol0E5bo81CziueMkEasd7952Px913cpyAKxE5gYUorYK-Pmm1_Pb3GjokSteVO7vKkcI7XmTa1o-sR5B_-Xp955Utb6AeOfpv9u-g0siOrU |
| CitedBy_id | crossref_primary_10_1038_s12276_022_00896_9 crossref_primary_10_1126_sciadv_ads4227 crossref_primary_10_3389_fimmu_2022_920865 crossref_primary_10_3390_cells13090752 crossref_primary_10_1016_j_bbrc_2025_152012 crossref_primary_10_1016_j_canlet_2024_217339 crossref_primary_10_1126_science_abq4822 crossref_primary_10_1038_s41467_025_59880_2 crossref_primary_10_1038_s41388_023_02777_5 crossref_primary_10_1084_jem_20211327 crossref_primary_10_1161_ATVBAHA_124_321781 crossref_primary_10_1242_dev_204654 crossref_primary_10_1038_s41368_023_00238_z crossref_primary_10_1016_j_cmpb_2025_108929 crossref_primary_10_1126_scitranslmed_abg8070 crossref_primary_10_1038_s41588_022_01061_8 crossref_primary_10_1186_s13059_024_03299_3 crossref_primary_10_1126_scitranslmed_adh8335 crossref_primary_10_1158_0008_5472_CAN_23_0453 crossref_primary_10_1164_rccm_202005_1989OC crossref_primary_10_1038_s41467_021_23807_4 crossref_primary_10_1016_j_devcel_2023_05_007 crossref_primary_10_1038_s41598_024_70911_8 crossref_primary_10_1172_JCI138519 crossref_primary_10_3390_biom13010185 crossref_primary_10_1016_j_biomaterials_2023_122460 crossref_primary_10_1016_j_omtm_2023_04_008 crossref_primary_10_1186_s13073_022_01110_1 crossref_primary_10_1038_s41551_022_00868_4 crossref_primary_10_1038_s41467_023_43387_9 crossref_primary_10_3390_v16111797 crossref_primary_10_1016_j_cmet_2022_09_004 crossref_primary_10_1158_2159_8290_CD_21_0999 crossref_primary_10_1016_j_ccell_2024_04_010 crossref_primary_10_1084_jem_20200667 crossref_primary_10_1089_neu_2024_0218 crossref_primary_10_7554_eLife_97764_3 crossref_primary_10_1093_molbev_msae123 crossref_primary_10_1038_s42255_023_00893_w crossref_primary_10_1016_j_compbiomed_2024_108322 crossref_primary_10_1172_JCI157281 crossref_primary_10_1038_s41467_020_16904_3 crossref_primary_10_1016_j_neures_2024_01_009 crossref_primary_10_1093_nargab_lqab011 crossref_primary_10_1113_JP282867 crossref_primary_10_1007_s00018_021_03916_5 crossref_primary_10_1038_s41586_024_08131_3 crossref_primary_10_1126_sciadv_adj1252 crossref_primary_10_1186_s13059_020_02171_4 crossref_primary_10_1038_s41392_022_01237_y crossref_primary_10_1172_JCI157279 crossref_primary_10_1038_s41593_024_01580_z crossref_primary_10_1038_s41586_021_04143_5 crossref_primary_10_1016_j_immuni_2024_08_018 crossref_primary_10_1016_j_neo_2024_101054 crossref_primary_10_1126_sciimmunol_abe3981 crossref_primary_10_1186_s13293_022_00467_7 crossref_primary_10_1016_j_immuni_2025_03_021 crossref_primary_10_1002_sim_9970 crossref_primary_10_1038_s41467_025_62878_5 crossref_primary_10_1152_ajplung_00360_2024 crossref_primary_10_3390_cells13090742 crossref_primary_10_1038_s41467_020_20063_w crossref_primary_10_1146_annurev_biodatasci_102523_103640 crossref_primary_10_1002_wics_1558 crossref_primary_10_1016_j_celrep_2023_112864 crossref_primary_10_1038_s41598_025_04917_1 crossref_primary_10_1038_s41598_021_91625_1 crossref_primary_10_1038_s41698_024_00749_w crossref_primary_10_1186_s13073_023_01205_3 crossref_primary_10_1186_s12859_024_05833_3 crossref_primary_10_1111_liv_16125 crossref_primary_10_1242_dev_204610 crossref_primary_10_1155_2022_1051652 crossref_primary_10_1016_j_mucimm_2025_06_008 crossref_primary_10_1038_s41467_023_42911_1 crossref_primary_10_1038_s41586_025_09411_2 crossref_primary_10_1186_s13073_023_01218_y crossref_primary_10_1126_sciimmunol_adp3978 crossref_primary_10_1038_s41388_023_02590_0 crossref_primary_10_1038_s41467_022_28407_4 crossref_primary_10_3390_cells11193125 crossref_primary_10_1016_j_cels_2025_101302 crossref_primary_10_3390_bioengineering12010031 crossref_primary_10_1016_j_bone_2024_117207 crossref_primary_10_3390_ijms231810425 crossref_primary_10_1186_s12983_022_00472_x crossref_primary_10_1016_j_molcel_2022_03_009 crossref_primary_10_1093_jxb_erac521 crossref_primary_10_7554_eLife_76781 crossref_primary_10_1016_j_compbiomed_2024_108351 crossref_primary_10_3389_fimmu_2022_965342 crossref_primary_10_1038_s42003_024_06182_w crossref_primary_10_1080_01621459_2021_1892701 crossref_primary_10_1186_s13059_024_03318_3 crossref_primary_10_3389_fcvm_2023_1142612 crossref_primary_10_1016_j_ygeno_2024_110805 crossref_primary_10_7554_eLife_97229 crossref_primary_10_1158_0008_5472_CAN_23_3918 crossref_primary_10_1073_pnas_2416987121 crossref_primary_10_1093_nar_gkaa582 crossref_primary_10_1038_s41591_024_02894_y crossref_primary_10_3390_ijms26157151 crossref_primary_10_1016_j_medj_2021_01_006 crossref_primary_10_1016_j_isci_2024_109124 crossref_primary_10_1038_s41587_022_01535_4 crossref_primary_10_1007_s10620_024_08570_y crossref_primary_10_1016_j_stemcr_2025_102539 crossref_primary_10_1093_hmg_ddab055 crossref_primary_10_3389_fimmu_2025_1571446 crossref_primary_10_1038_s41467_024_45692_3 crossref_primary_10_1038_s41467_023_36744_1 crossref_primary_10_1186_s12864_024_10364_5 crossref_primary_10_1016_j_cmet_2021_01_011 crossref_primary_10_1038_s41586_024_07791_5 crossref_primary_10_1101_gr_267047_120 crossref_primary_10_3389_fnagi_2023_1306004 crossref_primary_10_1016_j_cell_2022_02_015 crossref_primary_10_1161_ATVBAHA_124_321719 crossref_primary_10_3389_fcell_2021_617853 crossref_primary_10_1038_s41598_025_04401_w crossref_primary_10_1038_s41467_025_60775_5 crossref_primary_10_1084_jem_20210040 crossref_primary_10_1038_s41598_025_91742_1 crossref_primary_10_1016_j_stem_2022_09_010 crossref_primary_10_1038_s41591_022_01960_7 crossref_primary_10_1016_j_celrep_2024_114072 crossref_primary_10_1038_s41586_023_06512_8 crossref_primary_10_1007_s00262_022_03278_2 crossref_primary_10_3389_fgene_2022_1009316 crossref_primary_10_3389_fimmu_2023_1287656 crossref_primary_10_1016_j_ydbio_2021_08_001 crossref_primary_10_3389_fimmu_2021_670574 crossref_primary_10_1038_s41467_025_59805_z crossref_primary_10_1038_s43018_024_00773_6 crossref_primary_10_1093_immhor_vlaf037 crossref_primary_10_1016_j_devcel_2023_07_020 crossref_primary_10_1016_j_gpb_2022_11_011 crossref_primary_10_1186_s12916_022_02500_3 crossref_primary_10_7554_eLife_78512 crossref_primary_10_1084_jem_20230913 crossref_primary_10_1038_s41467_022_29356_8 crossref_primary_10_3389_fendo_2023_1004245 crossref_primary_10_1242_dev_200693 crossref_primary_10_1080_10618600_2025_2518185 crossref_primary_10_1038_s41598_023_27700_6 crossref_primary_10_1126_scitranslmed_abp8869 crossref_primary_10_1126_science_ade9516 crossref_primary_10_1152_ajprenal_00059_2025 crossref_primary_10_1038_s41467_025_63138_2 crossref_primary_10_1093_nar_gkac791 crossref_primary_10_1523_JNEUROSCI_0142_20_2020 crossref_primary_10_7554_eLife_86130 crossref_primary_10_1016_j_cell_2021_12_004 crossref_primary_10_1002_lary_30856 crossref_primary_10_1038_s41598_025_14398_x crossref_primary_10_1038_s41467_022_28593_1 crossref_primary_10_1016_j_molmet_2021_101248 crossref_primary_10_1016_j_cmet_2020_08_016 crossref_primary_10_1002_cti2_1420 crossref_primary_10_1038_s41586_022_05525_z crossref_primary_10_1038_s41588_022_01141_9 crossref_primary_10_1053_j_gastro_2020_09_032 crossref_primary_10_1038_s41586_025_09233_2 crossref_primary_10_26508_lsa_202201591 crossref_primary_10_1186_s12859_024_05926_z crossref_primary_10_1093_nar_gkac320 crossref_primary_10_1038_s41598_025_96683_3 crossref_primary_10_1016_j_stem_2021_01_003 crossref_primary_10_1093_nar_gkae945 crossref_primary_10_1038_s41590_022_01219_w crossref_primary_10_1038_s41592_025_02627_0 crossref_primary_10_1016_j_stemcr_2025_102577 crossref_primary_10_1007_s11427_023_2561_0 crossref_primary_10_1016_j_jtbi_2024_111769 crossref_primary_10_1038_s42003_024_06480_3 crossref_primary_10_1007_s00018_022_04555_0 crossref_primary_10_7554_eLife_103109 crossref_primary_10_1002_mc_23919 crossref_primary_10_7554_eLife_92844 crossref_primary_10_1093_gigascience_giaf101 crossref_primary_10_1167_iovs_66_3_52 crossref_primary_10_1002_cnr2_1935 crossref_primary_10_1016_j_csbj_2024_04_058 crossref_primary_10_1186_s12943_024_02209_2 crossref_primary_10_1186_s12864_024_10044_4 crossref_primary_10_7554_eLife_67396 crossref_primary_10_1002_jmv_28362 crossref_primary_10_1016_j_xpro_2025_103811 crossref_primary_10_1038_s41467_023_40584_4 crossref_primary_10_1158_2326_6066_CIR_23_0061 crossref_primary_10_1038_s41467_025_61422_9 crossref_primary_10_1002_brb3_70632 crossref_primary_10_1016_j_cell_2021_12_022 crossref_primary_10_1210_endocr_bqad196 crossref_primary_10_1126_sciimmunol_add3330 crossref_primary_10_1038_s41590_023_01608_9 crossref_primary_10_1038_s43588_023_00427_0 crossref_primary_10_1038_s41467_022_35264_8 crossref_primary_10_1016_j_csbj_2024_04_041 crossref_primary_10_1371_journal_pbio_3001032 crossref_primary_10_1016_j_devcel_2023_12_015 crossref_primary_10_1038_s41593_025_01875_9 crossref_primary_10_1101_gr_262717_120 crossref_primary_10_1016_j_crmeth_2021_100070 crossref_primary_10_1016_j_matbio_2025_01_005 crossref_primary_10_1093_biostatistics_kxad010 crossref_primary_10_1016_j_neuron_2023_01_007 crossref_primary_10_1167_iovs_62_9_24 crossref_primary_10_3389_fimmu_2023_1131814 crossref_primary_10_1016_j_semcancer_2023_06_006 crossref_primary_10_1038_s41586_022_04518_2 crossref_primary_10_1186_s12915_021_01034_z crossref_primary_10_1371_journal_pbio_3002389 crossref_primary_10_4049_jimmunol_2000975 crossref_primary_10_1016_j_stem_2023_04_005 crossref_primary_10_3389_fnagi_2025_1549518 crossref_primary_10_1016_j_cell_2021_07_015 crossref_primary_10_1126_science_abm1741 crossref_primary_10_1038_s41587_024_02193_4 crossref_primary_10_1097_BS9_0000000000000172 crossref_primary_10_1126_sciimmunol_abh3768 crossref_primary_10_1002_advs_202413161 crossref_primary_10_1038_s41586_023_06053_0 crossref_primary_10_1016_j_matbio_2022_03_001 crossref_primary_10_1126_science_abe1544 crossref_primary_10_1016_j_ygeno_2024_110898 crossref_primary_10_1038_s41523_022_00412_2 crossref_primary_10_7554_eLife_80881 crossref_primary_10_1038_s41467_023_38621_3 crossref_primary_10_1155_2021_7228584 crossref_primary_10_1038_s41467_025_62495_2 crossref_primary_10_1038_s41467_024_50362_5 crossref_primary_10_1038_s41467_025_60899_8 crossref_primary_10_3389_fimmu_2024_1354735 crossref_primary_10_1016_j_cell_2021_07_003 crossref_primary_10_1038_s41598_025_95721_4 crossref_primary_10_1371_journal_pcbi_1011413 crossref_primary_10_3390_genes14071330 crossref_primary_10_1038_s41598_024_60516_6 crossref_primary_10_1038_s41467_024_50251_x crossref_primary_10_1016_j_ajhg_2025_02_011 crossref_primary_10_1016_j_xpro_2024_103546 crossref_primary_10_1038_s12276_022_00874_1 crossref_primary_10_1016_j_xgen_2025_100766 crossref_primary_10_1084_jem_20240766 crossref_primary_10_1093_nar_gkaa183 crossref_primary_10_1016_j_crmeth_2022_100340 crossref_primary_10_1093_hmg_ddaf016 crossref_primary_10_2174_0115748936282613231211112920 crossref_primary_10_1165_rcmb_2021_0123OC crossref_primary_10_1371_journal_pcbi_1011447 crossref_primary_10_3390_genes12040509 crossref_primary_10_1016_j_postharvbio_2024_112954 crossref_primary_10_1126_science_ado3927 crossref_primary_10_1038_s41564_023_01405_y crossref_primary_10_1093_brain_awab446 crossref_primary_10_1126_science_adn7277 crossref_primary_10_1016_j_neuron_2020_12_003 crossref_primary_10_1016_j_celrep_2024_114911 crossref_primary_10_1038_s41467_021_26614_z crossref_primary_10_1038_s41598_021_04082_1 crossref_primary_10_1126_scitranslmed_adk0642 crossref_primary_10_1016_j_mucimm_2025_08_002 crossref_primary_10_1016_j_stem_2023_04_018 crossref_primary_10_1101_gr_279200_124 crossref_primary_10_3389_fimmu_2023_1242381 crossref_primary_10_1038_s41467_022_35388_x crossref_primary_10_1038_s42003_022_03541_3 crossref_primary_10_1038_s41590_022_01215_0 crossref_primary_10_1038_s41596_022_00716_4 crossref_primary_10_1155_2023_1447435 crossref_primary_10_1038_s41598_023_40683_8 crossref_primary_10_1186_s13059_023_02989_8 crossref_primary_10_1053_j_gastro_2025_01_007 crossref_primary_10_1126_sciadv_adt2771 crossref_primary_10_1186_s12859_020_03577_4 crossref_primary_10_1038_s41419_022_05115_x crossref_primary_10_7554_eLife_91576 crossref_primary_10_3389_ftox_2025_1636431 crossref_primary_10_1101_gr_277363_122 crossref_primary_10_1186_s13059_022_02783_y crossref_primary_10_1038_s41467_025_62478_3 crossref_primary_10_1038_s41597_021_00809_x crossref_primary_10_1016_j_isci_2024_110083 crossref_primary_10_1093_nargab_lqaf023 crossref_primary_10_1038_s41598_022_20106_w crossref_primary_10_1016_j_csbj_2022_12_001 crossref_primary_10_1128_spectrum_01277_25 crossref_primary_10_1371_journal_pcbi_1011854 crossref_primary_10_1016_j_bbrc_2022_01_094 crossref_primary_10_1002_ctm2_696 crossref_primary_10_1016_j_bbi_2023_06_021 crossref_primary_10_1038_s41467_024_48188_2 crossref_primary_10_1002_glia_24071 crossref_primary_10_1016_j_celrep_2025_116172 crossref_primary_10_14814_phy2_70537 crossref_primary_10_1128_msystems_00052_23 crossref_primary_10_1080_21505594_2025_2547326 crossref_primary_10_1161_CIRCULATIONAHA_120_045981 crossref_primary_10_1038_s41586_023_05753_x crossref_primary_10_1186_s12943_024_02040_9 crossref_primary_10_3389_fimmu_2021_630892 crossref_primary_10_1038_s41586_021_03634_9 crossref_primary_10_3390_ijms24010618 crossref_primary_10_1038_s41586_022_05649_2 crossref_primary_10_1038_s41587_023_01767_y crossref_primary_10_1016_j_xpro_2024_103135 crossref_primary_10_1038_s41467_024_55597_w crossref_primary_10_1158_1078_0432_CCR_22_2924 crossref_primary_10_7554_eLife_95897_3 crossref_primary_10_3389_fimmu_2021_642891 crossref_primary_10_1186_s13293_024_00661_9 crossref_primary_10_1007_s44307_025_00074_8 crossref_primary_10_2174_0109298673282799231211113347 crossref_primary_10_1084_jem_20220605 crossref_primary_10_1038_s41467_021_27492_1 crossref_primary_10_1038_s41467_024_54750_9 crossref_primary_10_1016_j_ajhg_2023_12_015 crossref_primary_10_1186_s12935_025_03811_0 crossref_primary_10_1038_s43587_023_00363_8 crossref_primary_10_1186_s13059_022_02828_2 crossref_primary_10_1002_advs_202501011 crossref_primary_10_1101_gr_268037_120 crossref_primary_10_1016_j_isci_2025_113432 crossref_primary_10_1002_advs_202206787 crossref_primary_10_1038_s41586_021_03188_w crossref_primary_10_1093_nargab_lqaf046 crossref_primary_10_1016_j_ebiom_2023_104749 crossref_primary_10_1016_j_ajhg_2023_12_011 crossref_primary_10_1038_s41586_021_04237_0 crossref_primary_10_1038_s12276_025_01539_5 crossref_primary_10_1038_s42003_024_05772_y crossref_primary_10_1093_neuonc_noac085 crossref_primary_10_1016_j_neuron_2025_02_001 crossref_primary_10_1186_s12967_023_04102_w crossref_primary_10_1186_s13040_024_00421_w crossref_primary_10_1016_j_cell_2024_09_034 crossref_primary_10_1038_s41540_024_00484_9 crossref_primary_10_3390_v13112284 crossref_primary_10_1038_s41598_023_28480_9 crossref_primary_10_1186_s13059_021_02525_6 crossref_primary_10_3390_ijms252011109 crossref_primary_10_1016_j_jbc_2025_110551 crossref_primary_10_1038_s42255_022_00531_x crossref_primary_10_1016_j_scib_2025_03_012 crossref_primary_10_1080_10618600_2021_1987254 crossref_primary_10_1002_advs_202308009 crossref_primary_10_1038_s43018_025_00905_6 crossref_primary_10_1016_j_cell_2021_12_031 crossref_primary_10_1038_s41590_022_01285_0 crossref_primary_10_1038_s41467_024_44823_0 crossref_primary_10_1016_j_ccell_2022_05_004 crossref_primary_10_1016_j_neuron_2024_07_018 crossref_primary_10_1186_s13059_020_02132_x crossref_primary_10_1152_ajpendo_00488_2024 crossref_primary_10_1038_s41593_023_01480_8 crossref_primary_10_1038_s41531_025_00899_z crossref_primary_10_1093_nargab_lqae134 crossref_primary_10_1089_cmb_2024_0614 crossref_primary_10_2147_JIR_S530446 crossref_primary_10_1186_s13059_020_02078_0 crossref_primary_10_1016_j_jgg_2021_06_001 crossref_primary_10_3389_fimmu_2024_1408212 crossref_primary_10_1016_j_celrep_2021_109969 crossref_primary_10_1038_s41523_021_00365_y crossref_primary_10_1016_j_celrep_2023_113380 crossref_primary_10_1038_s41467_023_39312_9 crossref_primary_10_1172_JCI174184 crossref_primary_10_1016_j_cell_2021_12_040 crossref_primary_10_1111_pbi_14294 crossref_primary_10_1126_sciimmunol_abl7482 crossref_primary_10_3390_jcdd9110374 crossref_primary_10_3389_fgene_2022_924877 crossref_primary_10_3390_ijms251910368 crossref_primary_10_1038_s44318_024_00298_9 crossref_primary_10_7554_eLife_68603 crossref_primary_10_1016_j_lfs_2023_121939 crossref_primary_10_1038_s41586_023_06508_4 crossref_primary_10_1016_j_cell_2025_02_015 crossref_primary_10_1016_j_stem_2024_08_002 crossref_primary_10_1038_s41420_025_02619_1 crossref_primary_10_1186_s13059_021_02360_9 crossref_primary_10_1038_s41589_024_01761_8 crossref_primary_10_1126_science_adp5182 crossref_primary_10_1126_science_adp7361 crossref_primary_10_1016_j_cell_2024_09_001 crossref_primary_10_1134_S1021443723602835 crossref_primary_10_3389_fonc_2022_990398 crossref_primary_10_1016_j_neuron_2025_04_024 crossref_primary_10_1038_s41467_021_27354_w crossref_primary_10_1016_j_stem_2024_08_008 crossref_primary_10_1038_s41467_024_45907_7 crossref_primary_10_1038_s41467_020_19350_3 crossref_primary_10_1038_s41587_020_00748_9 crossref_primary_10_1093_bib_bbae291 crossref_primary_10_1158_0008_5472_CAN_22_1062 crossref_primary_10_1093_humrep_deac183 crossref_primary_10_1038_s41598_021_02946_0 crossref_primary_10_15252_embr_202050944 crossref_primary_10_1002_advs_202307129 crossref_primary_10_3389_fbinf_2025_1554010 crossref_primary_10_1126_science_abq3061 crossref_primary_10_1038_s41467_021_25412_x crossref_primary_10_1038_s41586_021_03710_0 crossref_primary_10_1186_s12967_022_03702_2 crossref_primary_10_1038_s44318_024_00115_3 crossref_primary_10_1097_XCS_0000000000001340 crossref_primary_10_1093_nar_gkab095 crossref_primary_10_1126_science_abd9704 crossref_primary_10_1038_s41467_023_40424_5 crossref_primary_10_1038_s41590_022_01343_7 crossref_primary_10_1126_science_adf1046 crossref_primary_10_1371_journal_pgen_1011816 crossref_primary_10_3389_fmicb_2022_813187 crossref_primary_10_1038_s41586_023_06036_1 crossref_primary_10_1016_j_compbiomed_2023_107685 crossref_primary_10_1016_j_cels_2025_101346 crossref_primary_10_1158_2326_6066_CIR_22_0116 crossref_primary_10_3390_ijms252312700 crossref_primary_10_1186_s40478_024_01803_1 crossref_primary_10_1038_s41698_023_00488_4 crossref_primary_10_1038_s41591_022_02178_3 crossref_primary_10_1126_sciimmunol_adg0033 crossref_primary_10_1038_s41587_022_01250_0 crossref_primary_10_3389_fpsyt_2021_699033 crossref_primary_10_1007_s11538_023_01213_9 crossref_primary_10_1186_s12967_024_04885_6 crossref_primary_10_1038_s41467_022_35433_9 crossref_primary_10_1158_2159_8290_CD_22_0411 crossref_primary_10_1016_j_cmet_2021_10_004 crossref_primary_10_1126_sciimmunol_abq2061 crossref_primary_10_7554_eLife_92679_3 crossref_primary_10_1002_sim_9430 crossref_primary_10_1126_sciimmunol_aba0759 crossref_primary_10_1186_s12865_022_00525_0 crossref_primary_10_1016_j_isci_2024_110009 crossref_primary_10_1038_s41586_023_06423_8 crossref_primary_10_1172_JCI166954 crossref_primary_10_1093_bfgp_elae039 crossref_primary_10_1038_s41380_023_02314_6 crossref_primary_10_1155_2022_9714669 crossref_primary_10_1038_s41467_024_44689_2 crossref_primary_10_1038_s12276_022_00914_w crossref_primary_10_1126_scitranslmed_abj1270 crossref_primary_10_1158_0008_5472_CAN_22_1890 crossref_primary_10_1038_s42003_025_08277_4 crossref_primary_10_1038_s41586_022_04541_3 crossref_primary_10_1038_s41467_023_43006_7 crossref_primary_10_1101_gr_277881_123 crossref_primary_10_1038_s42255_020_00279_2 crossref_primary_10_1016_j_isci_2025_112988 crossref_primary_10_1038_s41586_022_04817_8 crossref_primary_10_1038_s41467_025_56280_4 crossref_primary_10_1016_j_celrep_2024_114558 crossref_primary_10_1128_jvi_00441_24 crossref_primary_10_1096_fj_202101531R crossref_primary_10_1038_s41564_023_01462_3 crossref_primary_10_1093_molehr_gaaf025 crossref_primary_10_1126_science_abi7377 crossref_primary_10_1007_s00401_024_02823_w crossref_primary_10_1007_s00018_023_04769_w crossref_primary_10_1016_j_jpha_2023_07_011 crossref_primary_10_1016_j_neo_2025_101230 crossref_primary_10_1016_j_tem_2021_04_009 crossref_primary_10_3390_cells11091589 crossref_primary_10_1002_advs_202411752 crossref_primary_10_1158_2159_8290_CD_23_1459 crossref_primary_10_1016_j_exphem_2021_05_001 crossref_primary_10_1186_s13071_023_05783_4 crossref_primary_10_1016_j_celrep_2023_112902 crossref_primary_10_1371_journal_pone_0271584 crossref_primary_10_1038_s41591_021_01576_3 crossref_primary_10_1002_1873_3468_70087 crossref_primary_10_1016_j_biomaterials_2023_122097 crossref_primary_10_3389_fncel_2021_676515 crossref_primary_10_3389_fpls_2025_1637176 crossref_primary_10_1186_s12915_023_01593_3 crossref_primary_10_1371_journal_pone_0323827 crossref_primary_10_1038_s41467_025_56623_1 crossref_primary_10_1126_science_adh1938 crossref_primary_10_1038_s41392_025_02226_7 crossref_primary_10_1016_j_ejca_2021_03_005 crossref_primary_10_7554_eLife_96425 crossref_primary_10_1002_advs_202402816 crossref_primary_10_15252_msb_20209833 crossref_primary_10_3389_fimmu_2024_1438004 crossref_primary_10_3390_pathogens13010062 crossref_primary_10_1016_j_cels_2023_03_004 crossref_primary_10_1038_s41589_023_01346_x crossref_primary_10_1038_s41392_024_01792_6 crossref_primary_10_1038_s41587_021_00830_w crossref_primary_10_1172_JCI174598 crossref_primary_10_1016_j_devcel_2025_06_016 crossref_primary_10_1101_gad_350269_122 crossref_primary_10_7554_eLife_70283 crossref_primary_10_1038_s41698_023_00444_2 crossref_primary_10_1016_j_molimm_2025_02_016 crossref_primary_10_1038_s41598_025_96657_5 crossref_primary_10_1523_ENEURO_0505_24_2025 crossref_primary_10_1002_iid3_981 crossref_primary_10_7554_eLife_95566 crossref_primary_10_1038_s41467_024_51649_3 crossref_primary_10_1038_s41586_021_04206_7 crossref_primary_10_1016_j_neuron_2022_06_021 crossref_primary_10_1038_s44319_024_00362_9 crossref_primary_10_1186_s13024_022_00517_z crossref_primary_10_1038_s42003_022_04093_2 crossref_primary_10_1186_s13024_021_00507_7 crossref_primary_10_1016_j_celrep_2025_115758 crossref_primary_10_1093_evlett_qraf012 crossref_primary_10_1038_s41593_023_01401_9 crossref_primary_10_1186_s12864_023_09722_6 crossref_primary_10_1126_sciimmunol_aba7350 crossref_primary_10_1126_sciimmunol_add0665 crossref_primary_10_7554_eLife_80090 crossref_primary_10_1172_JCI178975 crossref_primary_10_1186_s13073_023_01236_w crossref_primary_10_1158_1078_0432_CCR_22_2041 crossref_primary_10_1016_j_devcel_2025_06_030 crossref_primary_10_1038_s41586_022_05253_4 crossref_primary_10_1158_2326_6066_CIR_24_0246 crossref_primary_10_1038_s43018_021_00201_z crossref_primary_10_1016_j_celrep_2024_114586 crossref_primary_10_1186_s12931_025_03182_0 crossref_primary_10_1096_fj_202401909R crossref_primary_10_1007_s00774_024_01555_x crossref_primary_10_1016_j_ejphar_2025_178062 crossref_primary_10_1038_s41551_023_01107_0 crossref_primary_10_1186_s13059_020_02136_7 crossref_primary_10_7554_eLife_97764 crossref_primary_10_1038_s41586_025_09041_8 crossref_primary_10_1126_science_adh7688 crossref_primary_10_1038_s41591_023_02327_2 crossref_primary_10_1084_jem_20211777 crossref_primary_10_1093_imaiai_iaae036 crossref_primary_10_1038_s41598_023_35092_w crossref_primary_10_1016_j_cell_2024_07_002 crossref_primary_10_1158_0008_5472_CAN_21_0839 crossref_primary_10_1371_journal_ppat_1009240 crossref_primary_10_1038_s41588_024_01999_x crossref_primary_10_1186_s12859_022_05054_6 crossref_primary_10_1016_j_ymeth_2025_03_007 crossref_primary_10_3390_biomedicines11092564 crossref_primary_10_1093_bib_bbac223 crossref_primary_10_1126_science_abo5199 crossref_primary_10_1186_s12967_023_04438_3 crossref_primary_10_1016_j_csbj_2025_07_047 crossref_primary_10_1016_j_xgen_2024_100556 crossref_primary_10_1093_hr_uhaf029 crossref_primary_10_1016_j_gpb_2020_08_002 crossref_primary_10_1038_s41573_023_00688_4 crossref_primary_10_1681_ASN_2021040439 crossref_primary_10_1002_glia_24633 crossref_primary_10_1126_science_abf3041 crossref_primary_10_1126_sciadv_adr4310 crossref_primary_10_1007_s00262_024_03839_7 crossref_primary_10_1016_j_mucimm_2024_11_009 crossref_primary_10_1161_CIRCRESAHA_120_318479 crossref_primary_10_1038_s41467_020_17440_w crossref_primary_10_1186_s12864_023_09192_w crossref_primary_10_1186_s13059_020_02096_y crossref_primary_10_1186_s41043_025_01037_4 crossref_primary_10_1016_j_cels_2022_08_004 crossref_primary_10_1016_j_cpcardiol_2025_103005 crossref_primary_10_1038_s41467_024_49790_0 crossref_primary_10_1038_s41586_022_05215_w crossref_primary_10_1080_14737159_2023_2219843 crossref_primary_10_1038_s41467_025_59926_5 crossref_primary_10_1002_jnr_24618 crossref_primary_10_1016_j_gpb_2023_06_003 crossref_primary_10_1038_s41590_024_02052_z crossref_primary_10_1002_ijc_35079 crossref_primary_10_3389_fimmu_2025_1594879 crossref_primary_10_3389_fimmu_2025_1577040 crossref_primary_10_7554_eLife_97229_3 crossref_primary_10_1016_j_xgen_2024_100545 crossref_primary_10_3389_fgene_2020_00295 crossref_primary_10_1186_s12915_023_01711_1 crossref_primary_10_1016_j_isci_2024_111522 crossref_primary_10_1038_s43856_025_00860_4 crossref_primary_10_1016_j_cell_2020_12_016 crossref_primary_10_1210_endocr_bqac156 crossref_primary_10_1038_s41467_022_30511_4 crossref_primary_10_1038_s41467_023_38134_z crossref_primary_10_1038_s41467_024_50628_y crossref_primary_10_1002_1878_0261_70100 crossref_primary_10_1002_smtd_202300594 crossref_primary_10_1038_s41559_024_02404_w crossref_primary_10_1016_j_celrep_2025_115790 crossref_primary_10_1002_cyto_a_24777 crossref_primary_10_1097_BS9_0000000000000072 crossref_primary_10_1016_j_stem_2022_01_012 crossref_primary_10_1083_jcb_202403096 crossref_primary_10_1016_j_celrep_2025_115315 crossref_primary_10_1016_j_heliyon_2024_e34784 crossref_primary_10_1126_science_adi8828 crossref_primary_10_1038_s41597_023_02209_9 crossref_primary_10_1038_s41467_025_59073_x crossref_primary_10_7554_eLife_92844_3 crossref_primary_10_1016_j_jaci_2020_03_041 crossref_primary_10_1093_plcell_koac167 crossref_primary_10_3389_fimmu_2024_1425466 crossref_primary_10_1093_nargab_lqaa034 crossref_primary_10_1016_j_immuni_2021_11_017 crossref_primary_10_3389_fimmu_2020_00611 crossref_primary_10_1038_s41467_023_44186_y crossref_primary_10_1038_s41467_022_34467_3 crossref_primary_10_1161_CIRCULATIONAHA_120_052928 crossref_primary_10_1186_s13059_024_03241_7 crossref_primary_10_1016_j_bbi_2024_04_030 crossref_primary_10_3390_cells11020241 crossref_primary_10_1038_s41556_023_01337_z crossref_primary_10_1016_j_celrep_2025_115301 crossref_primary_10_1111_tpj_70064 crossref_primary_10_1016_j_stem_2021_08_015 crossref_primary_10_1038_s41586_025_08981_5 crossref_primary_10_1038_s41593_022_01093_7 crossref_primary_10_1038_s41598_022_16623_3 crossref_primary_10_1111_acel_13360 crossref_primary_10_1016_j_cell_2020_04_034 crossref_primary_10_1016_j_ajhg_2021_12_009 crossref_primary_10_1038_s41467_021_27901_5 crossref_primary_10_1158_2767_9764_CRC_25_0107 crossref_primary_10_1126_science_adf6812 crossref_primary_10_1186_s12859_025_06041_3 crossref_primary_10_1186_s13104_024_07008_y crossref_primary_10_1126_science_adf3786 crossref_primary_10_1242_dmm_049591 crossref_primary_10_1016_j_immuni_2020_09_002 crossref_primary_10_1016_j_immuni_2020_09_003 crossref_primary_10_1038_s41586_021_04026_9 crossref_primary_10_1172_JCI141837 crossref_primary_10_1038_s41467_023_41302_w crossref_primary_10_1016_j_matbio_2023_03_003 crossref_primary_10_1126_sciimmunol_abe2749 crossref_primary_10_1126_scitranslmed_adr3718 crossref_primary_10_1016_j_devcel_2024_06_016 crossref_primary_10_3389_fbioe_2022_829509 crossref_primary_10_1038_s41586_020_2266_0 crossref_primary_10_1186_s13059_025_03525_6 crossref_primary_10_1126_sciadv_adt7450 crossref_primary_10_1016_j_ccell_2023_01_004 crossref_primary_10_1172_JCI173892 crossref_primary_10_1038_s41413_025_00444_x crossref_primary_10_1186_s12943_025_02231_y crossref_primary_10_1111_jnc_15900 crossref_primary_10_1038_s41586_022_05660_7 crossref_primary_10_1016_j_cell_2022_07_024 crossref_primary_10_1038_s41467_023_42825_y crossref_primary_10_1038_s41467_021_21865_2 crossref_primary_10_1126_sciimmunol_abo3170 crossref_primary_10_1002_advs_202415083 crossref_primary_10_1093_hmg_ddac262 crossref_primary_10_1002_eji_202250270 crossref_primary_10_1038_s41467_021_24615_6 crossref_primary_10_1177_11786469251340237 crossref_primary_10_1038_s41588_023_01551_3 crossref_primary_10_1016_j_cell_2023_04_022 crossref_primary_10_1186_s13059_023_02873_5 crossref_primary_10_3389_fimmu_2024_1327405 crossref_primary_10_3389_fimmu_2024_1347453 crossref_primary_10_1038_s41467_023_37432_w crossref_primary_10_1371_journal_pcbi_1012014 crossref_primary_10_1038_s41467_024_47173_z crossref_primary_10_3389_fimmu_2025_1635483 crossref_primary_10_1016_j_cagd_2024_102288 crossref_primary_10_3389_fcell_2022_872688 crossref_primary_10_1038_s41467_024_47329_x crossref_primary_10_1126_scitranslmed_abb6731 crossref_primary_10_1002_lary_30718 crossref_primary_10_1371_journal_ppat_1008671 crossref_primary_10_1080_2162402X_2024_2320411 crossref_primary_10_1038_s41592_023_01814_1 crossref_primary_10_7717_peerj_19729 crossref_primary_10_1038_s42255_022_00613_w crossref_primary_10_1038_s41593_024_01600_y crossref_primary_10_1007_s13402_024_01025_6 crossref_primary_10_1007_s11914_023_00840_4 crossref_primary_10_1093_function_zqae015 crossref_primary_10_1016_j_biomaterials_2023_122163 crossref_primary_10_1016_j_coisb_2021_100375 crossref_primary_10_1038_s41467_024_51328_3 crossref_primary_10_1158_1078_0432_CCR_24_1304 crossref_primary_10_1016_j_chom_2025_06_006 crossref_primary_10_1016_j_clim_2023_109773 crossref_primary_10_1038_s41467_022_33623_z crossref_primary_10_1016_j_jid_2024_10_609 crossref_primary_10_1038_s41416_025_02981_y crossref_primary_10_1084_jem_20201699 crossref_primary_10_1186_s44477_025_00002_z crossref_primary_10_1186_s13073_020_00799_2 crossref_primary_10_1186_s40779_022_00434_8 crossref_primary_10_1038_s41467_021_27402_5 crossref_primary_10_1038_s44318_024_00213_2 crossref_primary_10_1038_s41467_023_44227_6 crossref_primary_10_1016_j_bbadis_2025_167693 crossref_primary_10_1016_j_cels_2022_06_005 crossref_primary_10_1186_s40478_022_01494_6 crossref_primary_10_1038_s41467_022_33364_z crossref_primary_10_1093_bib_bbac612 crossref_primary_10_3389_fimmu_2023_1137034 crossref_primary_10_4252_wjsc_v16_i3_287 crossref_primary_10_1093_pcmedi_pbab022 crossref_primary_10_1186_s40478_022_01472_y crossref_primary_10_3389_fncir_2023_1172464 crossref_primary_10_1038_s41540_025_00549_3 crossref_primary_10_1038_s44161_023_00295_x crossref_primary_10_1096_fj_202301724R crossref_primary_10_1016_j_immuni_2024_11_019 crossref_primary_10_1038_s43587_023_00368_3 crossref_primary_10_1016_j_immuni_2024_11_018 crossref_primary_10_1002_advs_202205395 crossref_primary_10_1111_srt_13710 crossref_primary_10_1007_s13402_023_00816_7 crossref_primary_10_1016_j_isci_2025_113130 crossref_primary_10_7554_eLife_97356_3 crossref_primary_10_1242_dev_198614 crossref_primary_10_1038_s42255_021_00373_z crossref_primary_10_3389_fgene_2021_637322 crossref_primary_10_1016_j_ijbiomac_2025_147504 crossref_primary_10_3390_cells12071044 crossref_primary_10_1016_j_ymthe_2025_04_039 crossref_primary_10_1038_s41467_022_34854_w crossref_primary_10_3389_fimmu_2024_1499301 crossref_primary_10_1016_j_isci_2025_113141 crossref_primary_10_1186_s13073_022_01055_5 crossref_primary_10_1016_j_stem_2024_11_013 crossref_primary_10_1038_s41590_021_01117_7 crossref_primary_10_7554_eLife_86032 crossref_primary_10_1097_HC9_0000000000000508 crossref_primary_10_1016_j_ccell_2025_08_009 crossref_primary_10_1038_s44161_025_00653_x crossref_primary_10_1242_dev_200557 crossref_primary_10_1016_j_xcrm_2025_102301 crossref_primary_10_1038_s41586_022_04711_3 crossref_primary_10_1038_s44318_025_00376_6 crossref_primary_10_1016_j_cell_2020_06_014 crossref_primary_10_1073_pnas_2008523117 crossref_primary_10_1093_procel_pwac038 crossref_primary_10_1186_s13059_025_03565_y crossref_primary_10_1016_j_celrep_2023_112514 crossref_primary_10_1038_s42255_023_00861_4 crossref_primary_10_1093_narcan_zcaf021 crossref_primary_10_1007_s12064_023_00408_x crossref_primary_10_1038_s41467_025_60338_8 crossref_primary_10_1016_j_jaci_2024_07_021 crossref_primary_10_1038_s41586_022_05402_9 crossref_primary_10_1038_s41375_021_01341_y crossref_primary_10_1038_s41551_022_00863_9 crossref_primary_10_1016_j_ccell_2023_11_001 crossref_primary_10_3389_fnmol_2022_818007 crossref_primary_10_1186_s13073_021_00941_8 crossref_primary_10_1126_science_abh3021 crossref_primary_10_1038_s41467_024_45614_3 crossref_primary_10_1038_s41467_019_13916_6 crossref_primary_10_1038_s44161_023_00260_8 crossref_primary_10_1038_s41467_023_38886_8 crossref_primary_10_1016_j_isci_2023_108497 crossref_primary_10_1016_j_cell_2020_12_032 crossref_primary_10_1002_advs_202103332 crossref_primary_10_1016_j_devcel_2022_12_004 crossref_primary_10_1016_j_cell_2023_02_032 crossref_primary_10_26508_lsa_202201683 crossref_primary_10_1093_nargab_lqaa064 crossref_primary_10_7554_eLife_82938 crossref_primary_10_1016_j_compbiomed_2023_106836 crossref_primary_10_1038_s41559_023_02186_7 crossref_primary_10_1016_j_xgen_2025_100875 crossref_primary_10_1016_j_ajhg_2023_08_017 crossref_primary_10_1038_s41597_025_05838_4 crossref_primary_10_1161_HYPERTENSIONAHA_124_22886 crossref_primary_10_1242_dev_200539 crossref_primary_10_1016_j_cell_2022_09_024 crossref_primary_10_1242_dev_202719 crossref_primary_10_1038_s41467_025_63290_9 crossref_primary_10_1038_s42255_023_00928_2 crossref_primary_10_1038_s41467_025_56135_y crossref_primary_10_1053_j_gastro_2022_07_081 crossref_primary_10_3390_ijms25094894 crossref_primary_10_1074_jbc_RA120_015679 crossref_primary_10_1038_s42003_023_05190_6 crossref_primary_10_1093_nargab_lqaa053 crossref_primary_10_1002_advs_202503932 crossref_primary_10_1111_cas_14795 crossref_primary_10_1126_science_abj4008 crossref_primary_10_1093_brain_awab337 crossref_primary_10_1016_j_immuni_2023_03_001 crossref_primary_10_1038_s41467_024_49608_z crossref_primary_10_1093_nar_gkac486 crossref_primary_10_1038_s41467_024_51995_2 crossref_primary_10_1214_21_AOAS1534 crossref_primary_10_1126_science_adk7978 crossref_primary_10_1186_s13059_021_02545_2 crossref_primary_10_1038_s43587_022_00205_z crossref_primary_10_1016_j_cels_2024_09_003 crossref_primary_10_1002_qub2_64 crossref_primary_10_1002_cti2_1308 crossref_primary_10_1016_j_tranon_2020_100981 crossref_primary_10_1073_pnas_2506976122 crossref_primary_10_1038_s41586_023_06361_5 crossref_primary_10_1186_s13059_024_03304_9 crossref_primary_10_1002_adhm_202302443 crossref_primary_10_1161_CIRCULATIONAHA_122_062952 crossref_primary_10_1093_bib_bbaa414 crossref_primary_10_1182_bloodadvances_2022009618 crossref_primary_10_1002_qub2_71 crossref_primary_10_1186_s13287_020_02043_5 crossref_primary_10_1038_s41586_024_07443_8 crossref_primary_10_1038_s41586_022_05139_5 crossref_primary_10_1158_2326_6066_CIR_22_0951 crossref_primary_10_1038_s41467_022_31591_y crossref_primary_10_1093_nargab_lqad106 crossref_primary_10_1038_s41392_023_01710_2 crossref_primary_10_1038_s41586_024_07465_2 crossref_primary_10_1038_s41467_023_38899_3 crossref_primary_10_1038_s41467_023_39443_z crossref_primary_10_1172_JCI173835 crossref_primary_10_1016_j_heares_2025_109376 crossref_primary_10_1002_JLB_4COVA0121_084RR crossref_primary_10_1186_s13059_024_03339_y crossref_primary_10_12688_f1000research_122312_1 crossref_primary_10_1126_sciimmunol_add8945 crossref_primary_10_1038_s41586_025_08634_7 crossref_primary_10_1002_ijc_33794 crossref_primary_10_15252_embj_2023114060 crossref_primary_10_1186_s13024_024_00725_9 crossref_primary_10_1038_s41586_025_08941_z crossref_primary_10_1126_scitranslmed_abc3961 crossref_primary_10_1016_j_stem_2020_09_017 crossref_primary_10_1016_j_stem_2023_07_012 crossref_primary_10_1093_bfgp_elad004 crossref_primary_10_1158_0008_5472_CAN_21_3840 crossref_primary_10_1002_adbi_202400334 crossref_primary_10_1038_s41556_025_01660_7 crossref_primary_10_1186_s12974_024_03210_8 crossref_primary_10_1016_j_compbiomed_2022_105269 crossref_primary_10_1016_j_cmet_2021_04_019 crossref_primary_10_1016_j_ccell_2022_12_001 crossref_primary_10_1186_s13395_021_00269_2 crossref_primary_10_4049_jimmunol_2200712 crossref_primary_10_7554_eLife_63092 crossref_primary_10_1038_s41467_023_37057_z crossref_primary_10_1183_16000617_0056_2022 crossref_primary_10_1186_s13287_020_01660_4 crossref_primary_10_1016_j_isci_2025_113537 crossref_primary_10_1016_j_jbc_2025_108568 crossref_primary_10_1016_j_intimp_2023_109886 crossref_primary_10_1038_s41467_022_33488_2 crossref_primary_10_1016_j_mbs_2021_108713 crossref_primary_10_1007_s12672_024_01672_z crossref_primary_10_1093_neuonc_noae172 crossref_primary_10_3390_biology12081148 crossref_primary_10_3389_fimmu_2025_1590953 crossref_primary_10_1038_s41586_021_03372_y crossref_primary_10_3389_fimmu_2021_804932 crossref_primary_10_1073_pnas_2008474117 crossref_primary_10_1038_s41586_024_08008_5 crossref_primary_10_1016_j_cell_2024_01_012 crossref_primary_10_1126_science_abf9277 crossref_primary_10_1016_j_ajhg_2022_09_008 crossref_primary_10_1038_s41597_023_02333_6 crossref_primary_10_3390_app132011512 crossref_primary_10_1126_science_abn0478 crossref_primary_10_1016_j_isci_2025_112214 crossref_primary_10_1038_s41467_024_53295_1 crossref_primary_10_1038_s41598_024_72255_9 crossref_primary_10_1016_j_jgg_2023_02_008 crossref_primary_10_1126_science_adf9941 crossref_primary_10_7554_eLife_67436 crossref_primary_10_1093_nargab_lqae098 crossref_primary_10_1038_s41416_024_02917_y crossref_primary_10_1093_lifemeta_loaf010 crossref_primary_10_1038_s41586_022_05308_6 crossref_primary_10_15252_embr_202256404 crossref_primary_10_7554_eLife_83855 crossref_primary_10_1084_jem_20240797 crossref_primary_10_1016_j_ebiom_2023_104865 crossref_primary_10_1186_s12943_025_02321_x crossref_primary_10_1038_s44161_025_00618_0 crossref_primary_10_3389_fgene_2022_900358 crossref_primary_10_1016_j_ccell_2023_05_004 crossref_primary_10_1016_j_cell_2020_08_001 crossref_primary_10_1186_s13024_023_00624_5 crossref_primary_10_1002_path_5751 crossref_primary_10_1172_JCI151189 crossref_primary_10_1126_sciimmunol_adh5462 crossref_primary_10_1371_journal_pgen_1009666 crossref_primary_10_1016_j_ajhg_2025_07_018 crossref_primary_10_1016_j_dmd_2024_100029 crossref_primary_10_1016_j_exer_2025_110578 crossref_primary_10_1038_s41586_022_04912_w crossref_primary_10_1126_sciimmunol_ade6924 crossref_primary_10_1038_s41467_022_32425_7 crossref_primary_10_1016_j_heliyon_2024_e39130 crossref_primary_10_1016_j_jneuroim_2022_577860 crossref_primary_10_1038_s41586_021_04075_0 crossref_primary_10_1016_j_actbio_2022_04_031 crossref_primary_10_1038_s41593_024_01848_4 crossref_primary_10_1186_s12859_024_05872_w crossref_primary_10_1016_j_ymthe_2023_12_018 crossref_primary_10_1158_0008_5472_CAN_22_3133 crossref_primary_10_1093_cvr_cvac138 crossref_primary_10_1126_sciimmunol_abq4573 crossref_primary_10_1038_s41588_023_01480_1 crossref_primary_10_7554_eLife_74913 crossref_primary_10_1186_s13059_021_02590_x crossref_primary_10_1158_2326_6066_CIR_23_1094 crossref_primary_10_1172_JCI188016 crossref_primary_10_1186_s13024_022_00584_2 crossref_primary_10_1016_j_cell_2023_08_044 crossref_primary_10_1186_s10020_025_01085_w crossref_primary_10_1136_jitc_2023_008053 crossref_primary_10_1038_s41590_020_0799_x crossref_primary_10_1038_s41467_021_27745_z crossref_primary_10_1038_s41467_024_54973_w crossref_primary_10_1016_j_devcel_2020_11_020 crossref_primary_10_1109_ACCESS_2024_3362647 crossref_primary_10_1186_s12859_025_06112_5 crossref_primary_10_1038_s42003_023_05182_6 crossref_primary_10_1016_j_cell_2023_08_039 crossref_primary_10_1073_pnas_2302938120 crossref_primary_10_1038_s41592_023_01841_y crossref_primary_10_1007_s00259_025_07489_4 crossref_primary_10_1038_s41467_023_39933_0 crossref_primary_10_1038_s41467_021_24807_0 crossref_primary_10_1161_CIRCGEN_123_004374 crossref_primary_10_1093_bfgp_elad025 crossref_primary_10_1093_cvr_cvac151 crossref_primary_10_1161_JAHA_124_038465 crossref_primary_10_1038_s41467_024_53954_3 crossref_primary_10_1038_s41597_024_04081_7 crossref_primary_10_1186_s13059_024_03259_x crossref_primary_10_1186_s12864_024_10160_1 crossref_primary_10_1038_s42003_022_04013_4 crossref_primary_10_1242_dev_199512 crossref_primary_10_1038_s41586_021_03208_9 crossref_primary_10_1093_nargab_lqae051 crossref_primary_10_1007_s11427_023_2557_x crossref_primary_10_1007_s44272_024_00018_8 crossref_primary_10_1128_MRA_00851_20 crossref_primary_10_1186_s12864_020_07300_8 crossref_primary_10_1158_1078_0432_CCR_24_3164 crossref_primary_10_1038_s41467_024_53429_5 crossref_primary_10_1016_j_immuni_2023_09_001 crossref_primary_10_1016_j_omtn_2023_08_017 crossref_primary_10_1073_pnas_2022350118 crossref_primary_10_1016_j_heliyon_2024_e30314 crossref_primary_10_1093_bioadv_vbae081 crossref_primary_10_1158_0008_5472_CAN_22_0090 crossref_primary_10_1371_journal_pgen_1010210 crossref_primary_10_1038_s41598_024_84018_7 crossref_primary_10_1016_j_biopsych_2024_05_023 crossref_primary_10_1186_s12967_024_05866_5 crossref_primary_10_1016_j_bpj_2023_11_3400 crossref_primary_10_1186_s13073_023_01179_2 crossref_primary_10_1038_s41423_023_01027_8 crossref_primary_10_1038_s41467_022_32634_0 crossref_primary_10_1016_j_cell_2022_11_031 crossref_primary_10_1093_bioadv_vbad159 crossref_primary_10_1038_s41467_025_61647_8 crossref_primary_10_1016_j_jaut_2021_102653 crossref_primary_10_1042_BSR20212093 crossref_primary_10_1038_s41586_024_08257_4 crossref_primary_10_1186_s12967_025_06368_8 crossref_primary_10_1038_s41531_023_00446_8 crossref_primary_10_1038_s41593_021_00880_y crossref_primary_10_3389_fcell_2024_1380902 crossref_primary_10_1186_s12967_025_06925_1 crossref_primary_10_7554_eLife_95897 crossref_primary_10_1038_s41467_021_25960_2 crossref_primary_10_1038_s41598_023_42238_3 crossref_primary_10_1093_bib_bbaf207 crossref_primary_10_1186_s13058_021_01487_8 crossref_primary_10_1681_ASN_0000000000000297 crossref_primary_10_1038_s41467_024_48267_4 crossref_primary_10_1038_s41536_022_00275_y crossref_primary_10_1016_j_bone_2025_117524 crossref_primary_10_1186_s40779_024_00526_7 crossref_primary_10_1038_s41586_023_06228_9 crossref_primary_10_1016_j_devcel_2022_01_006 crossref_primary_10_1101_gr_278812_123 crossref_primary_10_1038_s42003_022_04337_1 crossref_primary_10_1016_j_devcel_2022_01_008 crossref_primary_10_1016_j_ccell_2024_02_017 crossref_primary_10_1007_s11357_023_00870_x crossref_primary_10_1016_j_stem_2020_11_005 crossref_primary_10_1186_s12859_023_05250_y crossref_primary_10_1038_s41586_022_04916_6 crossref_primary_10_1093_bioadv_vbad171 crossref_primary_10_3389_fncel_2022_918041 crossref_primary_10_1126_scitranslmed_abk2267 crossref_primary_10_3390_ijms23126470 crossref_primary_10_1016_j_ydbio_2024_08_006 crossref_primary_10_3390_e24070995 crossref_primary_10_3390_genes13122265 crossref_primary_10_3390_genes13122264 crossref_primary_10_1371_journal_ppat_1012341 crossref_primary_10_1038_s41467_022_35238_w crossref_primary_10_1038_s43018_024_00879_x crossref_primary_10_3389_fonc_2021_683007 crossref_primary_10_7554_eLife_55851 crossref_primary_10_1371_journal_pone_0261242 crossref_primary_10_3389_fncir_2022_826497 crossref_primary_10_1038_s41586_022_05089_y crossref_primary_10_1038_s41598_023_37050_y crossref_primary_10_1038_s41592_021_01171_x crossref_primary_10_1158_0008_5472_CAN_22_1769 crossref_primary_10_1016_j_immuni_2022_10_008 crossref_primary_10_1038_s41593_024_01678_4 crossref_primary_10_1038_s41467_025_63935_9 crossref_primary_10_1002_ijc_34276 crossref_primary_10_1186_s12915_020_00947_5 crossref_primary_10_1007_s10875_024_01687_9 crossref_primary_10_1038_s41576_023_00586_w crossref_primary_10_1186_s12933_023_01818_3 crossref_primary_10_1186_s12864_022_08562_0 crossref_primary_10_1002_1878_0261_13124 crossref_primary_10_1093_toxsci_kfad092 crossref_primary_10_1183_13993003_04168_2020 crossref_primary_10_1002_widm_1414 crossref_primary_10_1016_j_bpj_2023_10_021 crossref_primary_10_1038_s41586_024_08453_2 crossref_primary_10_3389_fncel_2021_624826 crossref_primary_10_1038_s41467_024_49203_2 crossref_primary_10_7554_eLife_89338_3 crossref_primary_10_7554_eLife_95427 crossref_primary_10_1016_j_jid_2025_04_033 crossref_primary_10_1016_j_cell_2022_11_005 crossref_primary_10_1016_j_cropd_2023_100041 crossref_primary_10_1038_s41467_024_54515_4 crossref_primary_10_1158_2159_8290_CD_23_0240 crossref_primary_10_3389_fimmu_2024_1494476 crossref_primary_10_2337_db21_0830 crossref_primary_10_1038_s41593_022_01097_3 crossref_primary_10_1093_plphys_kiac265 crossref_primary_10_1038_s41467_023_43256_5 crossref_primary_10_1242_dev_202390 crossref_primary_10_1186_s12931_024_02706_4 crossref_primary_10_1016_j_compbiomed_2024_108989 crossref_primary_10_1093_bib_bbab295 crossref_primary_10_1186_s12974_021_02242_8 crossref_primary_10_3390_cancers16061213 crossref_primary_10_3389_fcvm_2022_881916 crossref_primary_10_1158_0008_5472_CAN_22_2682 crossref_primary_10_3390_jcm12041398 crossref_primary_10_1038_s41467_022_28772_0 crossref_primary_10_1038_s41467_020_19015_1 crossref_primary_10_1093_bib_bbae317 crossref_primary_10_1093_bioadv_vbad120 crossref_primary_10_1038_s41592_021_01282_5 crossref_primary_10_1038_s41467_023_44503_5 crossref_primary_10_1038_s44319_023_00013_5 crossref_primary_10_1038_s41551_023_01085_3 crossref_primary_10_1038_s41467_021_27856_7 crossref_primary_10_1186_s13059_024_03255_1 crossref_primary_10_1186_s13073_023_01259_3 crossref_primary_10_1021_acsnano_4c07610 crossref_primary_10_1038_s41598_020_76972_9 crossref_primary_10_1038_s41586_021_03363_z crossref_primary_10_1093_bib_bbad460 crossref_primary_10_1084_jem_20232357 crossref_primary_10_1007_s00401_024_02811_0 crossref_primary_10_7554_eLife_66954 crossref_primary_10_1038_s41598_022_07434_7 crossref_primary_10_1016_j_jcmgh_2025_101472 crossref_primary_10_1093_plcell_koaa055 crossref_primary_10_7554_eLife_103109_3 crossref_primary_10_1016_j_ccell_2023_09_011 crossref_primary_10_1038_s41590_020_0768_4 crossref_primary_10_1016_j_heliyon_2020_e05810 crossref_primary_10_1016_j_ygeno_2021_01_007 crossref_primary_10_7554_eLife_65615 crossref_primary_10_1016_j_immuni_2022_12_014 crossref_primary_10_1242_dev_204555 crossref_primary_10_1038_s41598_020_70353_y crossref_primary_10_1158_2159_8290_CD_22_0998 crossref_primary_10_1242_dev_202377 crossref_primary_10_1038_s41592_025_02632_3 crossref_primary_10_1002_mco2_765 crossref_primary_10_1016_j_cub_2022_10_015 crossref_primary_10_1038_s41467_024_47884_3 crossref_primary_10_1111_nph_17992 crossref_primary_10_1038_s41698_024_00509_w crossref_primary_10_1093_bib_bbae334 crossref_primary_10_1167_iovs_64_13_40 crossref_primary_10_1038_s41388_021_02054_3 crossref_primary_10_1038_s41467_021_24607_6 crossref_primary_10_1186_s44330_025_00035_6 crossref_primary_10_1016_j_humimm_2023_110735 crossref_primary_10_1126_science_abk2432 crossref_primary_10_3389_fnmol_2024_1373568 crossref_primary_10_1093_plcell_koaa060 crossref_primary_10_1016_j_ajhg_2024_10_001 crossref_primary_10_1161_CIRCULATIONAHA_121_058615 crossref_primary_10_1038_s12276_023_01115_9 crossref_primary_10_1002_eji_202149481 crossref_primary_10_1016_j_immuni_2023_07_007 crossref_primary_10_1038_s41592_024_02415_2 crossref_primary_10_1158_2159_8290_CD_23_0282 crossref_primary_10_1093_brain_awad058 crossref_primary_10_1038_s41467_023_38409_5 crossref_primary_10_1186_s13059_021_02584_9 crossref_primary_10_1016_j_ijbiomac_2025_145284 crossref_primary_10_1084_jem_20220038 crossref_primary_10_1084_jem_20191869 crossref_primary_10_1038_s41467_023_40503_7 crossref_primary_10_1126_scitranslmed_ade1283 crossref_primary_10_1093_carcin_bgaf038 crossref_primary_10_1038_s42003_024_07201_6 crossref_primary_10_1016_j_fsi_2024_109358 crossref_primary_10_1038_s44318_024_00184_4 crossref_primary_10_1161_CIRCRESAHA_121_319737 crossref_primary_10_1093_jbmrpl_ziae011 crossref_primary_10_1093_genetics_iyac017 crossref_primary_10_1016_j_stem_2023_03_005 crossref_primary_10_1038_s41467_024_45802_1 crossref_primary_10_3390_cancers13194885 crossref_primary_10_7554_eLife_73477 crossref_primary_10_1371_journal_ppat_1010453 crossref_primary_10_1136_annrheumdis_2021_221761 crossref_primary_10_1002_ajmg_c_31793 crossref_primary_10_1016_j_intimp_2023_111166 crossref_primary_10_1126_science_adf4721 crossref_primary_10_1038_s41386_020_0763_3 crossref_primary_10_1007_s00401_025_02889_0 crossref_primary_10_1038_s41593_022_01192_5 crossref_primary_10_1093_bib_bbac324 crossref_primary_10_1242_dev_202249 crossref_primary_10_1161_CIRCULATIONAHA_123_067931 crossref_primary_10_1186_s13578_025_01447_1 crossref_primary_10_3389_fcell_2021_645276 crossref_primary_10_1016_j_celrep_2024_115149 crossref_primary_10_1038_s41598_025_10795_4 crossref_primary_10_1038_s41593_020_00770_9 crossref_primary_10_1038_s41586_021_03489_0 crossref_primary_10_1038_s41559_023_02001_3 crossref_primary_10_7554_eLife_73488 crossref_primary_10_1093_bib_bbab034 crossref_primary_10_1016_j_cell_2021_06_023 crossref_primary_10_3389_fnins_2020_00538 crossref_primary_10_1038_s41467_021_24442_9 crossref_primary_10_1038_s42003_025_08730_4 crossref_primary_10_1007_s12672_024_01657_y crossref_primary_10_3390_biom15010021 crossref_primary_10_1126_science_abg0928 crossref_primary_10_1016_j_celrep_2025_115437 crossref_primary_10_1016_j_expneurol_2025_115207 crossref_primary_10_1016_j_stem_2022_08_002 crossref_primary_10_1016_j_stem_2023_03_009 crossref_primary_10_1093_hropen_hoae042 crossref_primary_10_1371_journal_ppat_1010430 crossref_primary_10_3390_ijms242216365 crossref_primary_10_1038_s41590_022_01311_1 crossref_primary_10_3389_fimmu_2022_972298 crossref_primary_10_1016_j_stem_2022_08_007 crossref_primary_10_1111_biom_13727 crossref_primary_10_1136_jitc_2020_002115 crossref_primary_10_1111_hepr_13585 crossref_primary_10_1530_EJE_21_1183 crossref_primary_10_7554_eLife_96951_3 crossref_primary_10_1038_s42003_025_08262_x crossref_primary_10_1111_acel_14354 crossref_primary_10_1016_j_xgen_2025_100984 crossref_primary_10_1016_j_celrep_2024_115123 crossref_primary_10_1016_j_celrep_2025_115427 crossref_primary_10_1016_j_xgen_2025_100986 crossref_primary_10_3389_fonc_2020_00973 crossref_primary_10_1016_j_cell_2023_09_015 crossref_primary_10_1016_j_cell_2023_09_013 crossref_primary_10_1186_s12859_024_05724_7 crossref_primary_10_1016_j_immuni_2024_07_006 crossref_primary_10_1101_gad_349930_122 crossref_primary_10_1038_s41467_025_60074_z crossref_primary_10_1038_s41588_025_02083_8 crossref_primary_10_7554_eLife_62766 crossref_primary_10_1186_s13059_024_03177_y crossref_primary_10_1016_j_stem_2025_06_009 crossref_primary_10_1126_science_abo1984 crossref_primary_10_1038_s41597_023_02833_5 crossref_primary_10_7554_eLife_60108 crossref_primary_10_1186_s13058_022_01585_1 crossref_primary_10_3390_pharmaceutics16060835 crossref_primary_10_3389_fimmu_2025_1562700 crossref_primary_10_1242_jcs_260753 crossref_primary_10_1111_acel_14320 crossref_primary_10_1038_s41467_023_37477_x crossref_primary_10_1038_s41593_022_01104_7 crossref_primary_10_1038_s41380_022_01566_y crossref_primary_10_1073_pnas_2026684118 crossref_primary_10_1038_s42255_022_00734_2 crossref_primary_10_1016_j_jgg_2023_06_005 crossref_primary_10_7554_eLife_85494 crossref_primary_10_3389_fimmu_2023_1162700 crossref_primary_10_1371_journal_ppat_1010405 crossref_primary_10_1111_cpr_13492 crossref_primary_10_1016_j_isci_2025_112804 crossref_primary_10_1073_pnas_2210113120 crossref_primary_10_15252_msb_202010060 crossref_primary_10_1038_s41467_024_53127_2 crossref_primary_10_1016_j_devcel_2021_01_017 crossref_primary_10_1093_nar_gkab632 crossref_primary_10_1007_s12672_024_01287_4 crossref_primary_10_1038_s41467_024_52783_8 crossref_primary_10_1084_jem_20212479 crossref_primary_10_1016_j_ccell_2021_07_007 crossref_primary_10_1038_s41467_023_44206_x crossref_primary_10_1038_s41467_023_37126_3 crossref_primary_10_1016_j_ccell_2021_07_004 crossref_primary_10_1038_s41587_023_01979_2 crossref_primary_10_1038_s41586_024_08133_1 crossref_primary_10_1158_1078_0432_CCR_24_0563 crossref_primary_10_1038_s41590_020_00848_3 crossref_primary_10_1002_hed_28195 crossref_primary_10_1093_nar_gkac978 crossref_primary_10_7554_eLife_76564 crossref_primary_10_1038_s42003_023_05132_2 crossref_primary_10_1186_s12964_023_01312_z crossref_primary_10_1038_s41556_024_01460_5 crossref_primary_10_1093_nar_gkad820 crossref_primary_10_1186_s13075_020_02343_4 crossref_primary_10_1186_s12859_023_05424_8 crossref_primary_10_7554_eLife_87696 crossref_primary_10_1186_s12864_020_06832_3 crossref_primary_10_1038_s41419_024_06840_1 crossref_primary_10_1371_journal_pone_0317343 crossref_primary_10_1016_j_molcel_2022_04_019 crossref_primary_10_1016_j_stem_2023_05_002 crossref_primary_10_1038_s41590_023_01530_0 crossref_primary_10_1016_j_isci_2025_112398 crossref_primary_10_1186_s40364_024_00605_w crossref_primary_10_1371_journal_pcbi_1012560 crossref_primary_10_1016_j_apsb_2021_08_006 crossref_primary_10_3389_fimmu_2023_1106652 crossref_primary_10_7554_eLife_89377_4 crossref_primary_10_1177_17534259231181029 crossref_primary_10_1016_j_immuni_2023_01_023 crossref_primary_10_1016_j_stem_2020_07_003 crossref_primary_10_1016_j_molcel_2022_06_036 crossref_primary_10_1038_s41467_022_29367_5 crossref_primary_10_1038_s41598_023_36070_y crossref_primary_10_1016_j_immuni_2023_01_029 crossref_primary_10_1186_s12915_020_00941_x crossref_primary_10_7554_eLife_76586 crossref_primary_10_1016_j_immuni_2025_04_002 crossref_primary_10_1038_s41598_020_67513_5 crossref_primary_10_1111_acel_13450 crossref_primary_10_1016_j_neuron_2020_11_010 crossref_primary_10_1038_s41467_020_16162_3 crossref_primary_10_1016_j_crmeth_2025_101026 crossref_primary_10_15252_embr_202152835 crossref_primary_10_1038_s41598_021_90797_0 crossref_primary_10_1038_s41467_024_53510_z crossref_primary_10_1186_s13059_025_03588_5 crossref_primary_10_1016_j_immuni_2023_01_014 crossref_primary_10_1002_1878_0261_13819 crossref_primary_10_1038_s41586_024_07895_y crossref_primary_10_1016_j_cell_2024_02_005 crossref_primary_10_1016_j_immuni_2023_01_010 crossref_primary_10_1038_s41586_024_07762_w crossref_primary_10_1038_s41587_022_01551_4 crossref_primary_10_1186_s13046_025_03517_1 crossref_primary_10_1161_CIRCRESAHA_123_324015 crossref_primary_10_1111_1471_0528_16970 crossref_primary_10_1002_glia_24349 crossref_primary_10_1093_nargab_lqad032 crossref_primary_10_1007_s12035_021_02591_8 crossref_primary_10_1038_s41467_023_36333_2 crossref_primary_10_1038_s41467_024_45165_7 crossref_primary_10_1101_gr_279345_124 crossref_primary_10_1158_1078_0432_CCR_24_3192 crossref_primary_10_1002_ctm2_1798 crossref_primary_10_1038_s41467_023_41095_y crossref_primary_10_3389_fimmu_2023_1240394 crossref_primary_10_1016_j_immuni_2023_01_003 crossref_primary_10_1038_s43018_021_00264_y crossref_primary_10_1242_dev_202614 crossref_primary_10_1038_s41467_023_38186_1 crossref_primary_10_3389_fcell_2022_884748 crossref_primary_10_1093_cvr_cvae085 crossref_primary_10_1016_j_cell_2021_08_020 crossref_primary_10_1038_s41421_023_00593_5 crossref_primary_10_1186_s12859_021_04472_2 crossref_primary_10_3389_abp_2025_13922 crossref_primary_10_1016_j_bbadis_2024_167041 crossref_primary_10_1101_gr_277040_122 crossref_primary_10_1126_scitranslmed_adx0027 crossref_primary_10_1016_j_stem_2020_07_022 crossref_primary_10_1038_s41588_024_01819_2 crossref_primary_10_1093_bib_bbab413 crossref_primary_10_1186_s13395_023_00324_0 crossref_primary_10_1038_s41590_025_02206_7 crossref_primary_10_1016_j_xphs_2025_103919 crossref_primary_10_1016_j_devcel_2023_08_022 crossref_primary_10_1038_s41467_025_59856_2 crossref_primary_10_1084_jem_20212059 crossref_primary_10_1371_journal_pbio_3002148 crossref_primary_10_1016_j_bbamcr_2022_119321 crossref_primary_10_1093_brain_awad404 crossref_primary_10_1101_gr_279372_124 crossref_primary_10_1177_11769343221123050 crossref_primary_10_3390_cells12101435 crossref_primary_10_1210_endocr_bqaf126 crossref_primary_10_1016_j_ydbio_2020_10_009 crossref_primary_10_1038_s41467_023_44117_x crossref_primary_10_1093_gbe_evae280 crossref_primary_10_1002_glia_24314 crossref_primary_10_1038_s41467_020_18781_2 crossref_primary_10_1038_s41588_020_0595_4 crossref_primary_10_1002_jmv_29009 crossref_primary_10_1038_s41467_024_47054_5 crossref_primary_10_1016_j_cell_2024_04_039 crossref_primary_10_1186_s12576_023_00894_0 crossref_primary_10_1016_j_cels_2024_01_001 crossref_primary_10_1016_j_stem_2025_08_015 crossref_primary_10_1002_advs_202301565 crossref_primary_10_1038_s41467_022_29719_1 crossref_primary_10_1038_s41467_021_22851_4 crossref_primary_10_1158_2159_8290_CD_21_0316 crossref_primary_10_3389_fcell_2022_798316 crossref_primary_10_1002_advs_202103675 crossref_primary_10_1038_s41586_022_05060_x crossref_primary_10_1038_s41586_025_08757_x crossref_primary_10_3389_fimmu_2024_1327372 crossref_primary_10_1186_s12864_023_09332_2 crossref_primary_10_1038_s43018_022_00337_6 crossref_primary_10_1016_j_chom_2023_09_003 crossref_primary_10_1186_s12931_023_02514_2 crossref_primary_10_1371_journal_pcbi_1010357 crossref_primary_10_3389_fimmu_2024_1452172 crossref_primary_10_26508_lsa_202402736 crossref_primary_10_1038_s41540_025_00506_0 crossref_primary_10_2337_db23_0030 crossref_primary_10_3389_fimmu_2023_1241283 crossref_primary_10_1158_2159_8290_CD_22_0192 crossref_primary_10_1016_j_mucimm_2023_11_008 crossref_primary_10_7554_eLife_77019 crossref_primary_10_1007_s00439_022_02510_4 crossref_primary_10_1158_2326_6066_CIR_21_1039 crossref_primary_10_1186_s13073_022_01023_z crossref_primary_10_1016_j_pld_2024_03_008 crossref_primary_10_1016_j_cels_2023_08_004 crossref_primary_10_1038_s41593_023_01452_y crossref_primary_10_1016_j_stem_2023_10_008 crossref_primary_10_1111_imcb_12811 crossref_primary_10_1158_1078_0432_CCR_24_1821 crossref_primary_10_1038_s41556_023_01103_1 crossref_primary_10_1016_j_crmeth_2025_101085 crossref_primary_10_1038_s41586_022_04649_6 crossref_primary_10_1016_j_crmeth_2025_101086 crossref_primary_10_1038_s41467_024_55470_w crossref_primary_10_1016_j_jbc_2022_102665 crossref_primary_10_7554_eLife_81525 crossref_primary_10_1016_j_csbj_2023_06_002 crossref_primary_10_1214_22_STS880 crossref_primary_10_1016_j_oraloncology_2025_107595 crossref_primary_10_1186_s12974_022_02627_3 crossref_primary_10_1038_s41467_023_42721_5 crossref_primary_10_1161_CIRCRESAHA_123_324082 crossref_primary_10_1038_s41586_021_03209_8 crossref_primary_10_3389_freae_2023_1245879 crossref_primary_10_7554_eLife_89482 crossref_primary_10_1093_biostatistics_kxaf024 crossref_primary_10_1016_j_cell_2025_03_028 crossref_primary_10_1038_s41467_022_32228_w crossref_primary_10_1038_s41467_023_42658_9 crossref_primary_10_1038_s41467_022_34011_3 crossref_primary_10_1038_s41467_021_26682_1 crossref_primary_10_1007_s00441_023_03850_x crossref_primary_10_1002_eji_202149702 crossref_primary_10_1371_journal_ppat_1009904 crossref_primary_10_1172_JCI164585 crossref_primary_10_1038_s41581_020_0262_0 crossref_primary_10_1158_0008_5472_CAN_24_0857 crossref_primary_10_15252_msb_20209620 crossref_primary_10_1111_acel_13969 crossref_primary_10_1002_wcms_1658 crossref_primary_10_3389_fimmu_2023_1107582 crossref_primary_10_1038_s42003_025_08333_z crossref_primary_10_1186_s13046_021_01955_1 crossref_primary_10_1159_000540352 crossref_primary_10_1093_biostatistics_kxaf012 crossref_primary_10_1016_j_ccell_2024_07_006 crossref_primary_10_1128_spectrum_00776_23 crossref_primary_10_1016_j_omto_2023_07_006 crossref_primary_10_1093_nar_gkae307 crossref_primary_10_1016_j_medj_2021_04_016 crossref_primary_10_3390_stats7030059 crossref_primary_10_1038_s41467_024_52846_w crossref_primary_10_1016_j_csbj_2024_01_008 crossref_primary_10_1186_s13059_024_03303_w crossref_primary_10_1038_s41587_021_01139_4 crossref_primary_10_1016_j_mocell_2024_100103 crossref_primary_10_1016_j_cell_2022_05_024 crossref_primary_10_1038_s41586_024_07962_4 crossref_primary_10_1101_gad_351292_123 crossref_primary_10_1126_scitranslmed_adq1086 crossref_primary_10_1016_j_cmet_2023_01_010 crossref_primary_10_1038_s41590_024_02023_4 crossref_primary_10_1186_s12859_022_04620_2 crossref_primary_10_1016_j_immuni_2024_05_007 crossref_primary_10_1084_jem_20240433 crossref_primary_10_1038_s41559_023_02281_9 crossref_primary_10_1038_s41593_024_01609_3 crossref_primary_10_1016_j_stem_2024_09_011 crossref_primary_10_1126_scitranslmed_adg1323 crossref_primary_10_1096_fj_202302003R crossref_primary_10_1038_s42003_023_05733_x crossref_primary_10_1158_0008_5472_CAN_24_0875 crossref_primary_10_7554_eLife_92679 crossref_primary_10_1016_j_heliyon_2024_e27473 crossref_primary_10_1038_s41698_024_00752_1 crossref_primary_10_1016_j_ccell_2021_10_001 crossref_primary_10_1186_s13062_023_00390_w crossref_primary_10_1186_s12915_024_01846_9 crossref_primary_10_1186_s12864_020_07358_4 crossref_primary_10_1038_s41556_021_00734_6 crossref_primary_10_1093_bib_bbaf378 crossref_primary_10_1016_j_patter_2025_101297 crossref_primary_10_1038_s41592_025_02624_3 crossref_primary_10_7554_eLife_87696_3 crossref_primary_10_1038_s41559_023_02170_1 crossref_primary_10_1093_nargab_lqad058 crossref_primary_10_1073_pnas_2221249120 crossref_primary_10_1016_j_chom_2022_12_005 crossref_primary_10_1158_0008_5472_CAN_24_0821 crossref_primary_10_1172_JCI176136 crossref_primary_10_1126_science_abb7709 crossref_primary_10_1371_journal_pone_0306248 crossref_primary_10_1038_s41590_023_01436_x crossref_primary_10_1002_jbt_70218 crossref_primary_10_1038_s42003_021_02739_1 crossref_primary_10_1097_HEP_0000000000001432 crossref_primary_10_3390_ijms22010261 crossref_primary_10_1016_j_cellsig_2024_111071 crossref_primary_10_1158_0008_5472_CAN_23_1183 crossref_primary_10_1126_sciimmunol_adq8796 crossref_primary_10_1093_nargab_lqad050 crossref_primary_10_1016_j_devcel_2024_12_019 crossref_primary_10_1186_s13059_025_03499_5 crossref_primary_10_1038_s41467_022_28497_0 crossref_primary_10_1093_gigascience_giae107 crossref_primary_10_1242_dev_200909 crossref_primary_10_1016_j_csbj_2020_10_007 crossref_primary_10_1016_j_devcel_2022_07_004 crossref_primary_10_1038_s41422_022_00643_9 crossref_primary_10_3390_cancers12102946 crossref_primary_10_15252_embj_2021109694 crossref_primary_10_3390_genes12010028 crossref_primary_10_1038_s43587_022_00257_1 crossref_primary_10_3389_fonc_2023_1253659 crossref_primary_10_1038_s41698_025_00816_w crossref_primary_10_1126_science_abj8695 crossref_primary_10_3389_fonc_2021_639013 crossref_primary_10_3389_fgene_2021_679616 crossref_primary_10_1016_j_cell_2021_11_016 crossref_primary_10_1016_j_neuron_2022_03_008 crossref_primary_10_1186_s12864_021_07974_8 crossref_primary_10_1016_j_immuni_2022_08_019 crossref_primary_10_1093_nargab_lqad068 crossref_primary_10_1016_j_celrep_2025_115909 crossref_primary_10_1038_s41586_025_08603_0 crossref_primary_10_3389_fphys_2021_812947 crossref_primary_10_1084_jem_20211924 crossref_primary_10_1186_s12915_021_01122_0 crossref_primary_10_1186_s13073_024_01418_0 crossref_primary_10_1016_j_exer_2024_110190 crossref_primary_10_1038_s41467_025_58585_w crossref_primary_10_1186_s12859_020_03797_8 crossref_primary_10_3389_fimmu_2023_1053920 crossref_primary_10_1007_s10120_023_01456_4 crossref_primary_10_1038_s41467_021_27232_5 crossref_primary_10_1016_j_cell_2021_11_024 crossref_primary_10_1177_0271678X211013700 crossref_primary_10_1016_j_celrep_2024_114328 crossref_primary_10_1186_s12967_024_04972_8 crossref_primary_10_1002_art_42674 crossref_primary_10_1186_s13058_022_01515_1 crossref_primary_10_1016_j_cell_2024_06_005 crossref_primary_10_3389_fimmu_2023_1083333 crossref_primary_10_1093_evlett_qrad013 crossref_primary_10_1136_bmjopen_2020_047281 crossref_primary_10_1038_s42003_022_04216_9 crossref_primary_10_1136_gutjnl_2021_325811 crossref_primary_10_1038_s43018_025_01023_z crossref_primary_10_4049_jimmunol_2200433 crossref_primary_10_3389_fimmu_2022_1032911 crossref_primary_10_1214_24_AAP2056 crossref_primary_10_1038_s41586_024_07254_x crossref_primary_10_1038_s41598_021_99003_7 crossref_primary_10_1016_j_diff_2025_100856 crossref_primary_10_1084_jem_20221755 crossref_primary_10_1186_s13059_023_02974_1 crossref_primary_10_1016_j_omtn_2024_102202 crossref_primary_10_1038_s43018_021_00180_1 crossref_primary_10_1084_jem_20210615 crossref_primary_10_3389_fimmu_2024_1430792 crossref_primary_10_1038_s41592_024_02503_3 crossref_primary_10_3390_cancers14215337 crossref_primary_10_3389_fimmu_2025_1648278 crossref_primary_10_1186_s13059_021_02505_w crossref_primary_10_1186_s13059_021_02407_x crossref_primary_10_1016_j_cell_2022_03_041 crossref_primary_10_1002_cne_25066 crossref_primary_10_1038_s41467_025_57157_2 crossref_primary_10_1038_s41467_025_58999_6 crossref_primary_10_1038_s44325_025_00061_x crossref_primary_10_1016_j_ccell_2024_09_011 crossref_primary_10_1097_TP_0000000000004466 crossref_primary_10_1038_s41467_021_25186_2 crossref_primary_10_1158_2159_8290_CD_22_0686 crossref_primary_10_1128_jvi_00647_25 crossref_primary_10_1038_s41467_023_37437_5 crossref_primary_10_1038_s41418_025_01447_1 crossref_primary_10_1038_s41590_024_01753_9 crossref_primary_10_1016_j_isci_2022_104225 crossref_primary_10_1007_s11357_023_00829_y crossref_primary_10_1038_s41587_022_01635_1 crossref_primary_10_1186_s12915_022_01363_7 crossref_primary_10_1038_s42003_020_01625_6 crossref_primary_10_3389_fnagi_2022_828457 crossref_primary_10_1093_bib_bbae494 crossref_primary_10_1016_j_ajpath_2025_06_004 crossref_primary_10_1371_journal_pone_0300567 crossref_primary_10_1002_eji_202350458 crossref_primary_10_1016_j_cell_2024_06_014 crossref_primary_10_1152_ajprenal_00134_2025 crossref_primary_10_1242_dev_203152 crossref_primary_10_1080_2162402X_2025_2528110 crossref_primary_10_1016_j_immuni_2023_12_005 crossref_primary_10_3389_fimmu_2022_984799 crossref_primary_10_1016_j_heliyon_2024_e27873 crossref_primary_10_1016_j_cub_2023_11_025 crossref_primary_10_1038_s41467_024_50881_1 crossref_primary_10_3390_ijms25084485 crossref_primary_10_1002_advs_202206939 crossref_primary_10_1038_s41593_024_01742_z crossref_primary_10_1073_pnas_2307722120 crossref_primary_10_1038_s41593_024_01764_7 crossref_primary_10_1186_s13059_020_02103_2 crossref_primary_10_1038_s41421_022_00490_3 crossref_primary_10_7554_eLife_71361 crossref_primary_10_7554_eLife_95566_3 crossref_primary_10_3390_cells14130983 crossref_primary_10_1111_cpr_13545 crossref_primary_10_1186_s13073_024_01288_6 crossref_primary_10_1016_j_jcjd_2021_03_007 crossref_primary_10_1016_j_isci_2023_106754 crossref_primary_10_1038_s41467_023_39099_9 crossref_primary_10_1126_science_add1236 crossref_primary_10_1371_journal_pcbi_1012084 crossref_primary_10_1158_2326_6066_CIR_24_0463 crossref_primary_10_1007_s11357_022_00521_7 crossref_primary_10_1038_s41380_022_01509_7 crossref_primary_10_1096_fj_202300601RRR crossref_primary_10_1016_j_ymthe_2023_04_020 crossref_primary_10_3389_fcell_2023_1194199 crossref_primary_10_1126_sciimmunol_ado4720 crossref_primary_10_1038_s41590_022_01189_z crossref_primary_10_1038_s41586_022_04489_4 crossref_primary_10_3390_e24081116 crossref_primary_10_1089_cmb_2021_0617 crossref_primary_10_1007_s00439_020_02116_8 crossref_primary_10_1038_s41467_023_38704_1 crossref_primary_10_1126_science_abg9302 crossref_primary_10_1038_s41598_025_13448_8 crossref_primary_10_7554_eLife_85530 crossref_primary_10_1128_jvi_00181_25 crossref_primary_10_1016_j_jid_2023_06_203 crossref_primary_10_1038_s12276_024_01388_8 crossref_primary_10_1073_pnas_2116797119 crossref_primary_10_1038_s41477_022_01178_y crossref_primary_10_1016_j_celrep_2024_115225 crossref_primary_10_1080_2162402X_2024_2429186 crossref_primary_10_3390_cells11040608 crossref_primary_10_1016_j_stem_2020_03_013 crossref_primary_10_1038_s41467_024_49050_1 crossref_primary_10_1164_rccm_202403_0569OC crossref_primary_10_1038_s41598_021_01366_4 crossref_primary_10_1038_s44161_023_00334_7 crossref_primary_10_1038_s41467_022_28039_8 crossref_primary_10_1371_journal_pgen_1010746 crossref_primary_10_1038_s41467_022_31707_4 crossref_primary_10_3389_fcell_2021_769193 crossref_primary_10_1002_lary_31088 crossref_primary_10_1186_s13059_021_02451_7 crossref_primary_10_1038_s41598_022_22282_1 crossref_primary_10_1002_smtd_202301801 crossref_primary_10_1002_1873_3468_15009 crossref_primary_10_1101_gr_268482_120 crossref_primary_10_1038_s41467_024_52292_8 crossref_primary_10_1093_gigascience_giaa126 crossref_primary_10_1111_cpr_13516 crossref_primary_10_1016_j_ajo_2024_10_001 crossref_primary_10_1371_journal_pbio_3001746 crossref_primary_10_1093_bib_bbae457 crossref_primary_10_1016_j_stem_2021_11_007 crossref_primary_10_3390_jpm11060448 crossref_primary_10_1007_s12539_024_00603_4 crossref_primary_10_1038_s41588_022_01157_1 crossref_primary_10_1002_acr2_11255 crossref_primary_10_1073_pnas_2312757121 crossref_primary_10_1016_j_neuron_2022_05_001 crossref_primary_10_1038_s41467_021_24781_7 crossref_primary_10_1016_j_devcel_2024_10_004 crossref_primary_10_1038_s41564_024_01628_7 crossref_primary_10_1016_j_modpat_2024_100508 crossref_primary_10_1016_j_biopha_2024_116283 crossref_primary_10_1002_sim_10213 crossref_primary_10_1007_s11357_025_01561_5 crossref_primary_10_1126_sciimmunol_add4374 crossref_primary_10_1016_j_ajt_2025_08_004 crossref_primary_10_1111_nyas_15015 crossref_primary_10_1038_s41592_024_02390_8 crossref_primary_10_1101_gr_277278_122 crossref_primary_10_1038_s41467_025_56124_1 crossref_primary_10_1038_s41597_022_01676_w crossref_primary_10_26508_lsa_202101246 crossref_primary_10_3389_fimmu_2023_1030198 crossref_primary_10_1016_j_stem_2021_07_004 crossref_primary_10_1002_jbm4_10631 crossref_primary_10_1186_s13073_023_01185_4 crossref_primary_10_3389_fgene_2022_862634 crossref_primary_10_1038_s41422_023_00909_w crossref_primary_10_1371_journal_pcbi_1010097 crossref_primary_10_1002_oby_24264 crossref_primary_10_1016_j_devcel_2024_07_013 crossref_primary_10_1016_j_isci_2022_104419 crossref_primary_10_1186_s13073_024_01291_x crossref_primary_10_1016_j_cell_2022_08_025 crossref_primary_10_1038_s42255_023_00806_x crossref_primary_10_1093_nargab_lqab102 crossref_primary_10_1126_science_adi6412 crossref_primary_10_3389_fimmu_2025_1475480 crossref_primary_10_4049_jimmunol_2100439 crossref_primary_10_1084_jem_20202726 crossref_primary_10_7554_eLife_69065 crossref_primary_10_1016_j_ydbio_2025_08_025 crossref_primary_10_3389_fonc_2025_1526177 crossref_primary_10_3389_fimmu_2024_1507218 crossref_primary_10_1016_j_csbj_2023_10_006 crossref_primary_10_1038_s41467_022_30557_4 crossref_primary_10_1038_s41523_025_00803_1 crossref_primary_10_3390_genes12111796 crossref_primary_10_1016_j_devcel_2024_07_007 crossref_primary_10_1101_gr_251603_119 crossref_primary_10_3390_cells11203319 crossref_primary_10_1038_s41593_022_01180_9 crossref_primary_10_1016_j_cub_2023_02_013 crossref_primary_10_3389_fcell_2021_673642 crossref_primary_10_1038_s42003_023_04588_6 crossref_primary_10_1016_j_clim_2022_109209 crossref_primary_10_1038_s43587_023_00424_y crossref_primary_10_1186_s13059_023_02893_1 crossref_primary_10_1371_journal_pbio_3002633 crossref_primary_10_1016_j_cell_2025_06_037 crossref_primary_10_1038_s41467_024_47425_y crossref_primary_10_1038_s41467_021_22449_w crossref_primary_10_1002_jnr_24842 crossref_primary_10_1016_j_celrep_2024_114390 crossref_primary_10_1016_j_immuni_2024_01_011 crossref_primary_10_1038_s41598_023_42858_9 crossref_primary_10_1126_scitranslmed_adm6783 crossref_primary_10_3389_fcell_2023_1240289 crossref_primary_10_1360_SSM_2024_0263 crossref_primary_10_3389_fimmu_2025_1582645 crossref_primary_10_1038_s41559_022_01906_9 crossref_primary_10_1038_s42003_025_07594_y crossref_primary_10_1186_s13287_023_03444_y crossref_primary_10_1038_s41467_024_52762_z crossref_primary_10_1371_journal_ppat_1009799 crossref_primary_10_7554_eLife_60223 crossref_primary_10_7554_eLife_97356 crossref_primary_10_1073_pnas_2417224122 crossref_primary_10_1002_eji_202149298 crossref_primary_10_1016_j_jaci_2022_05_025 crossref_primary_10_1093_bib_bbab565 crossref_primary_10_1007_s00262_020_02713_6 crossref_primary_10_1016_j_xpro_2024_102986 crossref_primary_10_1242_dev_201229 crossref_primary_10_3389_fimmu_2022_1038134 crossref_primary_10_1093_noajnl_vdaf099 crossref_primary_10_1186_s12859_023_05349_2 crossref_primary_10_1007_s00401_021_02322_2 crossref_primary_10_1371_journal_ppat_1010775 crossref_primary_10_1038_s41467_024_50465_z crossref_primary_10_3389_fnut_2023_1212196 crossref_primary_10_1016_j_csbj_2022_08_043 crossref_primary_10_1038_s41598_024_73356_1 crossref_primary_10_1016_j_gpb_2020_09_002 crossref_primary_10_15252_embj_2020107277 crossref_primary_10_1007_s12561_022_09344_8 crossref_primary_10_1136_jitc_2023_008628 crossref_primary_10_3389_fphar_2023_1173649 crossref_primary_10_1093_bib_bbae621 crossref_primary_10_7554_eLife_91576_3 crossref_primary_10_1016_j_cub_2022_07_038 crossref_primary_10_1073_pnas_2023174118 crossref_primary_10_1016_j_csbj_2022_08_031 crossref_primary_10_3389_fendo_2022_945347 crossref_primary_10_1038_s41467_021_25957_x crossref_primary_10_7554_eLife_88414 crossref_primary_10_1038_s41598_023_51137_6 crossref_primary_10_3390_genes12101558 crossref_primary_10_1172_JCI135763 crossref_primary_10_1016_j_joca_2024_06_009 crossref_primary_10_15252_emmm_202216805 crossref_primary_10_1038_s44161_024_00460_w crossref_primary_10_1186_s13059_021_02552_3 crossref_primary_10_1186_s13059_023_02897_x crossref_primary_10_1093_nar_gkaa437 crossref_primary_10_1111_apha_70031 crossref_primary_10_3390_cells10113073 crossref_primary_10_1016_j_cell_2023_03_007 crossref_primary_10_1172_jci_insight_176596 crossref_primary_10_1016_j_ccell_2022_09_007 crossref_primary_10_1158_0008_5472_CAN_24_2346 crossref_primary_10_1002_ohn_1197 crossref_primary_10_1242_dev_200361 crossref_primary_10_1007_s11704_022_1172_z crossref_primary_10_1038_s41467_023_40076_5 crossref_primary_10_1186_s13059_023_03019_3 crossref_primary_10_1016_j_csbj_2022_08_029 crossref_primary_10_1038_s41467_021_24467_0 crossref_primary_10_1038_s41588_022_01203_y crossref_primary_10_1093_bib_bbac424 crossref_primary_10_1038_s41416_024_02737_0 crossref_primary_10_1016_j_cell_2022_06_007 crossref_primary_10_1186_s13059_025_03576_9 crossref_primary_10_1016_j_isci_2023_108694 crossref_primary_10_1073_pnas_1918314117 crossref_primary_10_1016_j_isci_2023_108213 crossref_primary_10_1038_s41467_024_49881_y crossref_primary_10_1016_j_ccell_2023_12_010 crossref_primary_10_1093_bib_bbab531 crossref_primary_10_1016_j_jid_2022_01_017 crossref_primary_10_1016_j_molmet_2025_102105 crossref_primary_10_1158_2767_9764_CRC_23_0489 crossref_primary_10_1161_JAHA_125_041738 crossref_primary_10_1016_j_ccell_2023_12_005 crossref_primary_10_1038_s41598_022_26434_1 crossref_primary_10_1093_nar_gkad521 crossref_primary_10_1093_nar_gkae1298 crossref_primary_10_1111_jipb_13495 crossref_primary_10_1038_s41586_024_08535_1 crossref_primary_10_1371_journal_pcbi_1010492 crossref_primary_10_1101_gr_278843_123 crossref_primary_10_1016_j_eururo_2024_05_026 crossref_primary_10_1038_s41590_022_01295_y crossref_primary_10_1093_bib_bbab517 crossref_primary_10_1126_science_adf7044 crossref_primary_10_1038_s41593_024_01726_z crossref_primary_10_1093_nar_gkad1023 crossref_primary_10_1371_journal_pgen_1010392 crossref_primary_10_3389_fphys_2020_591450 crossref_primary_10_7554_eLife_96425_3 crossref_primary_10_1038_s42003_022_03128_y crossref_primary_10_1016_j_isci_2024_108990 crossref_primary_10_1038_s41590_022_01403_y crossref_primary_10_1038_s41467_020_15816_6 crossref_primary_10_1038_s41598_021_02584_6 crossref_primary_10_1093_jrsssb_qkae111 crossref_primary_10_7554_eLife_61973 crossref_primary_10_1038_s41467_023_42751_z crossref_primary_10_1101_gr_277698_123 crossref_primary_10_4049_jimmunol_2200098 crossref_primary_10_1007_s11424_024_3202_4 crossref_primary_10_7554_eLife_84092 crossref_primary_10_1111_jnc_16120 crossref_primary_10_1016_j_stemcr_2025_102452 crossref_primary_10_1016_j_jii_2025_100879 crossref_primary_10_1002_advs_202415681 crossref_primary_10_1186_s13059_024_03404_6 crossref_primary_10_1038_s42003_022_04264_1 crossref_primary_10_1101_gr_280224_124 crossref_primary_10_3389_fphys_2023_1316635 crossref_primary_10_1038_s41467_023_36005_1 crossref_primary_10_1161_CIRCRESAHA_119_315940 crossref_primary_10_1093_nargab_lqac056 crossref_primary_10_1038_s41587_020_0605_1 crossref_primary_10_1146_annurev_biodatasci_012220_100601 crossref_primary_10_1016_j_jep_2024_119165 crossref_primary_10_1038_s41598_024_53993_2 crossref_primary_10_1186_s13059_022_02654_6 crossref_primary_10_1038_s41586_025_09487_w crossref_primary_10_1038_s41590_023_01579_x crossref_primary_10_1038_s41477_025_02051_4 crossref_primary_10_1038_s44319_024_00117_6 crossref_primary_10_1161_CIRCULATIONAHA_122_060985 crossref_primary_10_1164_rccm_202310_1975OC crossref_primary_10_1038_s41467_021_21177_5 crossref_primary_10_1186_s40364_025_00756_4 crossref_primary_10_1016_j_biopha_2025_117851 crossref_primary_10_1038_s41598_024_65053_w crossref_primary_10_1073_pnas_2214842120 crossref_primary_10_1016_j_jid_2024_12_027 crossref_primary_10_1038_s41586_022_05688_9 crossref_primary_10_1038_s43018_022_00336_7 crossref_primary_10_1111_nmo_14997 crossref_primary_10_3389_fonc_2022_878920 crossref_primary_10_1016_j_cell_2020_05_006 crossref_primary_10_1371_journal_pbio_3003120 crossref_primary_10_1371_journal_pcbi_1011785 crossref_primary_10_1371_journal_pcbi_1011300 crossref_primary_10_1038_s42003_024_07004_9 crossref_primary_10_1093_nar_gkae1257 crossref_primary_10_1093_biostatistics_kxae010 crossref_primary_10_3389_fendo_2022_842937 crossref_primary_10_1038_s41598_022_23162_4 crossref_primary_10_1016_j_devcel_2022_04_003 crossref_primary_10_1016_j_neuron_2021_09_020 crossref_primary_10_1038_s41582_023_00809_y crossref_primary_10_1038_s44161_023_00405_9 crossref_primary_10_1210_endocr_bqae148 crossref_primary_10_1038_s41556_024_01508_6 crossref_primary_10_1126_sciimmunol_abm2084 crossref_primary_10_1016_j_immuni_2022_09_002 crossref_primary_10_1016_j_ccell_2025_07_014 crossref_primary_10_3389_fcell_2023_1135025 crossref_primary_10_1038_s41540_023_00322_4 crossref_primary_10_3389_fnmol_2023_1160707 crossref_primary_10_1038_s41596_023_00827_6 crossref_primary_10_7554_eLife_89338 crossref_primary_10_1038_s43018_024_00881_3 crossref_primary_10_1038_s41467_024_52167_y crossref_primary_10_7554_eLife_91648 crossref_primary_10_1093_nar_gkad570 crossref_primary_10_1038_s43018_023_00566_3 crossref_primary_10_1073_pnas_2002082117 crossref_primary_10_1016_j_isci_2024_110872 crossref_primary_10_1038_s41590_023_01575_1 crossref_primary_10_1038_s41598_022_16127_0 crossref_primary_10_1158_1078_0432_CCR_23_2378 crossref_primary_10_1073_pnas_1912139117 crossref_primary_10_3389_fimmu_2021_738795 crossref_primary_10_1016_j_biopha_2025_117876 crossref_primary_10_1038_s43018_023_00709_6 crossref_primary_10_1093_cvr_cvaf021 crossref_primary_10_7554_eLife_81868 crossref_primary_10_1126_sciimmunol_abd8411 crossref_primary_10_1186_s44342_025_00044_5 crossref_primary_10_1128_mbio_02562_24 crossref_primary_10_7554_eLife_69413 crossref_primary_10_1186_s13059_022_02663_5 crossref_primary_10_1089_dna_2021_0923 crossref_primary_10_3389_fimmu_2022_1012884 crossref_primary_10_12688_f1000research_75243_1 crossref_primary_10_1016_j_molp_2020_10_012 crossref_primary_10_1038_s41586_022_04713_1 crossref_primary_10_3390_ijms26051949 crossref_primary_10_1016_j_intimp_2025_114739 crossref_primary_10_1177_15353702231191109 crossref_primary_10_1038_s41592_025_02617_2 crossref_primary_10_1093_nargab_lqac018 crossref_primary_10_1186_s12943_024_02110_y crossref_primary_10_3390_cells12030346 crossref_primary_10_1093_bioinformatics_btae540 crossref_primary_10_1038_s41467_023_36983_2 crossref_primary_10_7554_eLife_88414_4 crossref_primary_10_1016_j_molmet_2025_102159 crossref_primary_10_1038_s41593_025_02027_9 crossref_primary_10_1186_s13059_022_02698_8 crossref_primary_10_1038_s41592_023_02128_y crossref_primary_10_1038_s43018_022_00447_1 crossref_primary_10_1111_acel_13984 crossref_primary_10_1016_j_cell_2020_11_009 crossref_primary_10_1016_j_celrep_2025_116039 crossref_primary_10_2147_CCID_S404381 crossref_primary_10_1038_s42003_025_08378_0 crossref_primary_10_1016_j_intimp_2023_110624 crossref_primary_10_1161_JAHA_120_016528 crossref_primary_10_1038_s41467_022_34879_1 crossref_primary_10_1016_j_chom_2025_03_004 crossref_primary_10_1038_s41467_024_46773_z crossref_primary_10_1038_s42003_021_02146_6 crossref_primary_10_3389_fendo_2022_860286 crossref_primary_10_1038_s41467_025_61316_w crossref_primary_10_1038_s41591_020_1074_2 crossref_primary_10_1016_j_neuron_2021_03_024 crossref_primary_10_1016_j_celrep_2025_116064 crossref_primary_10_1038_s41586_022_04584_6 crossref_primary_10_1038_s41598_022_26141_x crossref_primary_10_7554_eLife_89482_3 crossref_primary_10_1084_jem_20241403 crossref_primary_10_3389_fcell_2022_982477 crossref_primary_10_3390_life13112215 crossref_primary_10_1093_gigascience_giac017 crossref_primary_10_1002_sim_9384 crossref_primary_10_1038_s41467_023_39717_6 crossref_primary_10_1016_j_xcrm_2025_102027 crossref_primary_10_1093_bib_bbae198 crossref_primary_10_1016_j_xcrm_2025_102029 crossref_primary_10_1038_s41467_024_47945_7 crossref_primary_10_1080_21655979_2021_1964252 crossref_primary_10_3390_cancers13174456 crossref_primary_10_1002_art_42960 crossref_primary_10_1186_s13059_023_02933_w crossref_primary_10_1038_s41598_021_95532_3 crossref_primary_10_1186_s12864_023_09743_1 crossref_primary_10_3389_fgene_2022_867880 crossref_primary_10_1038_s41467_024_54579_2 crossref_primary_10_1038_s41586_024_07898_9 crossref_primary_10_7554_eLife_89377 crossref_primary_10_1016_j_visres_2024_108465 crossref_primary_10_1523_JNEUROSCI_0222_21_2021 crossref_primary_10_15252_embj_2022112590 crossref_primary_10_1038_s41467_020_17281_7 crossref_primary_10_1158_2159_8290_CD_23_0426 crossref_primary_10_1038_s41593_022_01131_4 crossref_primary_10_1038_s41467_023_42021_y crossref_primary_10_3389_fimmu_2021_733539 crossref_primary_10_1038_s41467_024_49885_8 crossref_primary_10_1007_s00401_024_02831_w crossref_primary_10_1158_2326_6066_CIR_21_0137 crossref_primary_10_1016_j_ccell_2021_09_010 crossref_primary_10_1038_s41380_023_02248_z crossref_primary_10_3390_antiox14020214 crossref_primary_10_1038_s41385_022_00572_1 crossref_primary_10_1016_j_devcel_2023_10_012 crossref_primary_10_15252_emmm_202114455 crossref_primary_10_1038_s41590_024_01926_6 crossref_primary_10_1093_bioinformatics_btae462 crossref_primary_10_1172_JCI174051 crossref_primary_10_1084_jem_20221816 crossref_primary_10_1038_s41587_022_01440_w crossref_primary_10_1038_s41467_025_62259_y crossref_primary_10_1097_MPA_0000000000002357 crossref_primary_10_1007_s12026_024_09513_5 crossref_primary_10_1007_s12035_024_04419_7 crossref_primary_10_1016_j_isci_2023_107755 crossref_primary_10_1016_j_cell_2021_04_048 crossref_primary_10_3390_ijms22115988 crossref_primary_10_1101_gr_276449_121 crossref_primary_10_1016_j_immuni_2021_07_006 crossref_primary_10_1016_j_labinv_2023_100170 crossref_primary_10_1038_s41418_021_00866_0 crossref_primary_10_1186_s12859_022_04741_8 crossref_primary_10_4049_jimmunol_2300762 crossref_primary_10_1016_j_neuron_2023_06_024 crossref_primary_10_1186_s12864_024_10203_7 crossref_primary_10_1053_j_gastro_2024_07_025 crossref_primary_10_1186_s13059_024_03457_7 crossref_primary_10_1038_s42003_022_04211_0 crossref_primary_10_1093_jleuko_qiad136 crossref_primary_10_1126_sciadv_adt5939 crossref_primary_10_1186_s13059_024_03435_z crossref_primary_10_7554_eLife_58716 crossref_primary_10_1016_j_isci_2025_113329 crossref_primary_10_1038_s43587_021_00142_3 crossref_primary_10_1016_j_jaci_2025_01_009 crossref_primary_10_3390_v14040837 crossref_primary_10_1186_s12864_023_09898_x crossref_primary_10_1186_s13073_022_01075_1 crossref_primary_10_1038_s41590_024_01992_w crossref_primary_10_1038_s41698_022_00331_2 crossref_primary_10_1038_s41586_022_05274_z crossref_primary_10_1002_ggn2_202500003 crossref_primary_10_1016_j_cell_2022_12_031 crossref_primary_10_1681_ASN_2020121742 crossref_primary_10_1038_s41467_024_45665_6 crossref_primary_10_1016_j_isci_2023_106480 crossref_primary_10_3390_ai6050094 crossref_primary_10_1093_bib_bbaf487 crossref_primary_10_1016_j_ymthe_2025_01_034 crossref_primary_10_1038_s41467_022_28508_0 crossref_primary_10_3390_biomedicines12081674 crossref_primary_10_1038_s41467_021_27035_8 crossref_primary_10_1186_s13024_022_00551_x crossref_primary_10_1038_s42003_025_07938_8 crossref_primary_10_1161_CIRCRESAHA_121_320090 crossref_primary_10_7554_eLife_95427_3 crossref_primary_10_1186_s13059_025_03608_4 crossref_primary_10_1002_alz_70012 crossref_primary_10_1038_s41593_020_00736_x crossref_primary_10_1146_annurev_neuro_100119_110036 crossref_primary_10_1038_s41467_025_61841_8 crossref_primary_10_1038_s41467_021_26069_2 crossref_primary_10_1038_s41467_025_57632_w crossref_primary_10_1182_bloodadvances_2020002843 crossref_primary_10_1016_j_stem_2024_03_017 crossref_primary_10_3389_fimmu_2023_1224591 crossref_primary_10_3389_fncel_2021_688243 crossref_primary_10_1016_j_cell_2021_04_014 crossref_primary_10_1158_2326_6066_CIR_24_0513 crossref_primary_10_12688_openreseurope_15989_1 crossref_primary_10_1038_s41467_022_35297_z crossref_primary_10_1038_s41586_023_06342_8 crossref_primary_10_1016_j_molmet_2025_102208 crossref_primary_10_1038_s41598_022_07685_4 crossref_primary_10_26508_lsa_202201503 crossref_primary_10_1002_glia_24388 crossref_primary_10_1038_s41593_022_01011_x crossref_primary_10_1038_s41467_022_35262_w crossref_primary_10_1126_sciimmunol_adp6667 crossref_primary_10_1038_s42003_024_06835_w crossref_primary_10_1126_science_adn9850 crossref_primary_10_1126_sciadv_adq2290 crossref_primary_10_1038_s41598_022_16158_7 crossref_primary_10_1002_cbf_3737 crossref_primary_10_1007_s00439_022_02477_2 crossref_primary_10_1038_s42003_021_02440_3 crossref_primary_10_1016_j_stem_2021_03_022 crossref_primary_10_1055_a_2299_7880 crossref_primary_10_3389_fimmu_2023_1152003 crossref_primary_10_1016_j_stem_2024_03_004 crossref_primary_10_1016_j_heliyon_2024_e37185 crossref_primary_10_7554_eLife_70341 crossref_primary_10_1038_s41467_025_59306_z crossref_primary_10_7554_eLife_96951 crossref_primary_10_1158_2326_6066_CIR_21_0588 crossref_primary_10_3390_cancers16101924 crossref_primary_10_1016_j_ccell_2023_06_006 crossref_primary_10_7554_eLife_65445 crossref_primary_10_1038_s42003_022_04255_2 crossref_primary_10_3390_cells12121577 crossref_primary_10_7554_eLife_91648_4 crossref_primary_10_1038_s41590_023_01655_2 crossref_primary_10_1016_j_gpb_2022_10_001 crossref_primary_10_1084_jem_20200920 crossref_primary_10_1186_s13578_023_01120_5 crossref_primary_10_1523_JNEUROSCI_2371_23_2024 crossref_primary_10_1016_j_cub_2023_08_061 crossref_primary_10_1016_j_heliyon_2024_e33196 crossref_primary_10_1172_JCI164637 crossref_primary_10_1186_s12915_022_01264_9 crossref_primary_10_1038_s41467_024_49236_7 crossref_primary_10_1111_imcb_12670 crossref_primary_10_1126_science_abj1966 crossref_primary_10_1038_s41586_020_2499_y crossref_primary_10_1038_s41467_023_41033_y crossref_primary_10_1038_s41590_025_02276_7 crossref_primary_10_4049_jimmunol_2100824 crossref_primary_10_1038_s41467_024_49312_y crossref_primary_10_3389_fphar_2021_673485 crossref_primary_10_1093_brain_awad286 crossref_primary_10_1126_sciimmunol_ads7377 crossref_primary_10_3389_fdmed_2025_1581376 crossref_primary_10_1007_s12672_024_01461_8 crossref_primary_10_1186_s12967_025_06540_0 crossref_primary_10_1038_s41467_024_47949_3 crossref_primary_10_1016_j_molcel_2022_10_022 crossref_primary_10_1038_s41467_024_51450_2 crossref_primary_10_1093_nar_gkab1071 crossref_primary_10_1093_stmcls_sxaf012 crossref_primary_10_1093_bib_bbad266 crossref_primary_10_3390_cells12060959 crossref_primary_10_1038_s41590_023_01504_2 crossref_primary_10_1016_j_cmet_2023_06_007 crossref_primary_10_1038_s41586_020_03126_2 crossref_primary_10_1371_journal_pgen_1009846 crossref_primary_10_1038_s42003_023_05011_w crossref_primary_10_3389_fimmu_2023_1113735 crossref_primary_10_1038_s41590_025_02241_4 crossref_primary_10_1097_COH_0000000000000961 crossref_primary_10_1093_bib_bbad294 crossref_primary_10_7554_eLife_51254 crossref_primary_10_1007_s00335_024_10039_2 crossref_primary_10_1186_s12974_025_03425_3 crossref_primary_10_1186_s13059_023_03036_2 crossref_primary_10_1038_s41564_020_0729_6 crossref_primary_10_7554_eLife_68925 crossref_primary_10_1158_2326_6066_CIR_21_0536 crossref_primary_10_1038_s41467_023_43619_y crossref_primary_10_1016_j_copbio_2024_103111 crossref_primary_10_1096_fj_202501385R crossref_primary_10_1007_s12035_025_04965_8 crossref_primary_10_3389_fcell_2021_761300 crossref_primary_10_1016_j_devcel_2022_02_017 crossref_primary_10_1038_s41593_025_01947_w crossref_primary_10_1126_sciimmunol_abm2508 crossref_primary_10_4049_jimmunol_2400467 crossref_primary_10_3390_cancers13205243 crossref_primary_10_1038_s41588_025_02220_3 crossref_primary_10_1038_s41698_023_00441_5 crossref_primary_10_1038_s41467_023_43498_3 crossref_primary_10_1002_eji_202149209 crossref_primary_10_1126_sciimmunol_abo3420 crossref_primary_10_1093_bioinformatics_btaf399 crossref_primary_10_26508_lsa_202101315 crossref_primary_10_1007_s00401_025_02869_4 crossref_primary_10_1016_j_immuni_2023_08_002 crossref_primary_10_1016_j_neuron_2023_08_015 crossref_primary_10_1158_2159_8290_CD_23_0007 crossref_primary_10_1186_s40364_024_00632_7 crossref_primary_10_1016_j_cell_2021_02_048 crossref_primary_10_1002_bies_202200084 crossref_primary_10_1038_s41556_022_00996_8 crossref_primary_10_1038_s41598_025_95496_8 crossref_primary_10_3390_neurosci6030065 crossref_primary_10_1016_j_cmet_2022_11_009 crossref_primary_10_1158_2326_6066_CIR_22_0283 crossref_primary_10_1128_mbio_00849_25 crossref_primary_10_1038_s41467_025_61627_y crossref_primary_10_1093_bib_bbac387 crossref_primary_10_1371_journal_pone_0322864 crossref_primary_10_1002_ijc_35385 crossref_primary_10_1038_s41590_025_02232_5 crossref_primary_10_1093_neuonc_noad021 crossref_primary_10_1186_s12859_023_05590_9 crossref_primary_10_1038_s41390_025_04100_2 crossref_primary_10_1038_s41467_022_33117_y crossref_primary_10_1038_s41598_024_61758_0 crossref_primary_10_1681_ASN_0000000000000098 crossref_primary_10_7554_eLife_76932 crossref_primary_10_1016_j_postharvbio_2024_113223 crossref_primary_10_1016_j_cell_2023_05_001 crossref_primary_10_1016_j_stem_2023_08_009 crossref_primary_10_1371_journal_ppat_1013402 crossref_primary_10_1016_j_cels_2025_101261 crossref_primary_10_3390_cells12131784 crossref_primary_10_1111_jcmm_18262 crossref_primary_10_1016_j_neo_2024_101072 crossref_primary_10_1158_2159_8290_CD_20_0461 crossref_primary_10_1016_j_cell_2021_02_021 crossref_primary_10_1111_pbi_70267 crossref_primary_10_1038_s41467_021_25624_1 crossref_primary_10_1186_s12885_023_11100_0 crossref_primary_10_1210_endocr_bqaa108 crossref_primary_10_1038_s41598_024_74985_2 crossref_primary_10_1091_mbc_E21_11_0561 crossref_primary_10_1093_bib_bbae101 crossref_primary_10_1371_journal_pone_0275600 crossref_primary_10_1038_s41467_020_16239_z crossref_primary_10_1002_eji_202149235 crossref_primary_10_1038_s41467_021_21675_6 crossref_primary_10_1038_s41587_021_00875_x crossref_primary_10_1126_science_adi5199 crossref_primary_10_1242_jcs_261468 crossref_primary_10_1007_s12311_025_01809_y crossref_primary_10_1038_s41586_022_05385_7 crossref_primary_10_1038_s41591_024_03011_9 crossref_primary_10_2147_JIR_S482047 crossref_primary_10_1126_sciimmunol_adk5041 crossref_primary_10_1002_ctm2_70281 crossref_primary_10_1038_s42255_021_00509_1 crossref_primary_10_1161_CIRCULATIONAHA_120_051921 crossref_primary_10_1038_s41586_022_05056_7 crossref_primary_10_3390_cells13060522 crossref_primary_10_1016_j_celrep_2024_114471 crossref_primary_10_1126_science_adp6325 crossref_primary_10_1038_s41586_025_08717_5 crossref_primary_10_1242_dmm_052106 crossref_primary_10_1038_s41598_024_74732_7 |
| Cites_doi | 10.1093/nar/gks042 10.1186/gb-2014-15-2-r29 10.1038/nmeth.2967 10.1038/s41467-018-07931-2 10.21105/joss.00861 10.1038/nmeth.4150 10.1038/nbt.4096 10.1186/s13059-015-0866-z 10.1016/j.cels.2018.06.011 10.1038/nbt.3102 10.1038/nmeth.4380 10.1038/nmeth.2930 10.1038/nmeth.4324 10.1038/s41467-017-02554-5 10.1038/s41592-018-0229-2 10.1038/nmeth.4220 10.1186/gb-2010-11-10-r106 10.1111/j.2517-6161.1991.tb01857.x 10.1038/nmeth.4292 10.1038/nrg3833 10.1186/s13059-017-1382-0 10.1186/s13059-015-0844-5 10.1038/nature14590 10.1038/s41598-018-22297-7 10.1016/j.cell.2019.05.031 10.1186/s13059-014-0550-8 10.1093/bioinformatics/btp616 10.2202/1544-6115.1027 10.1038/nmeth.4263 10.1371/journal.pcbi.1004333 10.1093/biostatistics/kxx053 10.1038/nbt.3192 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2019 2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s) 2019 – notice: 2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88E 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS 7X8 7S9 L.6 5PM DOA |
| DOI | 10.1186/s13059-019-1874-1 |
| DatabaseName | Open Access资源_Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest SciTech Premium Collection Natural Science Collection Biological Science Collection ProQuest Central Natural Science Collection ProQuest One ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection ProQuest Health & Medical Collection Medical Database Biological Science Database Proquest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic AGRICOLA AGRICOLA - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | Publicly Available Content Database AGRICOLA MEDLINE MEDLINE - Academic CrossRef |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1474-760X |
| EndPage | 296 |
| ExternalDocumentID | oai_doaj_org_article_6bb8ef5e3bc44c6e84eabcff715b74c3 PMC6927181 31870423 10_1186_s13059_019_1874_1 |
| Genre | Research Support, Non-U.S. Gov't Evaluation Study Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NHGRI NIH HHS grantid: DP2 HG009623 – fundername: NINDS NIH HHS grantid: R35 NS097404 – fundername: NIH HHS grantid: OT2 OD026673 – fundername: NIMH NIH HHS grantid: R01 MH071679 |
| GroupedDBID | --- 0R~ 29H 4.4 53G 5GY 5VS 7X7 88E 8FE 8FH 8FI 8FJ AAFWJ AAHBH AAJSJ AASML ABUWG ACGFO ACGFS ACJQM ACPRK ADBBV ADUKV AEGXH AFKRA AFPKN AHBYD AIAGR ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIAM AOIJS BAPOH BAWUL BBNVY BCNDV BENPR BFQNJ BHPHI BMC BPHCQ BVXVI C6C CCPQU EBD EBLON EBS EMOBN FYUFA GROUPED_DOAJ GX1 HCIFZ HMCUK HYE IAO IGS IHR ISR ITC KPI LK8 M1P M7P PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PUEGO ROL RPM RSV SJN SOJ SV3 UKHRP AAYXX AFFHD CITATION 3V. ACRMQ ADINQ ALIPV C24 CGR CUY CVF ECM EIF NPM 7XB 8FK AZQEC DWQXO GNUQQ K9. PKEHL PQEST PQUKI PRINS 7X8 7S9 L.6 5PM |
| ID | FETCH-LOGICAL-c770t-c685f20fd84ba89d98339aa783ddab207cc455dc8bfda8aeb2d3fd5f89e58353 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 2514 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000511887800004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1474-760X 1474-7596 |
| IngestDate | Fri Oct 03 12:39:08 EDT 2025 Tue Nov 04 02:01:22 EST 2025 Fri Sep 05 09:40:10 EDT 2025 Wed Oct 01 14:33:52 EDT 2025 Tue Oct 14 14:12:12 EDT 2025 Thu Jan 02 22:59:14 EST 2025 Tue Nov 18 21:41:35 EST 2025 Sat Nov 29 04:55:54 EST 2025 Sat Sep 06 07:24:40 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Single-cell RNA-seq Normalization |
| Language | English |
| License | Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c770t-c685f20fd84ba89d98339aa783ddab207cc455dc8bfda8aeb2d3fd5f89e58353 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23 |
| ORCID | 0000-0001-9448-8833 |
| OpenAccessLink | https://www.proquest.com/docview/2341180571?pq-origsite=%requestingapplication% |
| PMID | 31870423 |
| PQID | 2341180571 |
| PQPubID | 2040232 |
| PageCount | 1 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_6bb8ef5e3bc44c6e84eabcff715b74c3 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6927181 proquest_miscellaneous_2477632399 proquest_miscellaneous_2330331096 proquest_journals_2341180571 pubmed_primary_31870423 crossref_citationtrail_10_1186_s13059_019_1874_1 crossref_primary_10_1186_s13059_019_1874_1 springer_journals_10_1186_s13059_019_1874_1 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-12-23 |
| PublicationDateYYYYMMDD | 2019-12-23 |
| PublicationDate_xml | – month: 12 year: 2019 text: 2019-12-23 day: 23 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Genome Biology |
| PublicationTitleAbbrev | Genome Biol |
| PublicationTitleAlternate | Genome Biol |
| PublicationYear | 2019 |
| Publisher | BioMed Central Springer Nature B.V BMC |
| Publisher_xml | – name: BioMed Central – name: Springer Nature B.V – name: BMC |
| References | R Bacher (1874_CR6) 2017; 14 D Risso (1874_CR9) 2018; 9 1874_CR34 DJ McCarthy (1874_CR22) 2012; 40 CA Vallejos (1874_CR7) 2015; 11 Leland McInnes (1874_CR36) 2018; 3 1874_CR38 G Wang (1874_CR35) 2018; 8 GK Smyth (1874_CR30) 2004; 3 Harold Pimentel (1874_CR24) 2017; 14 CW Law (1874_CR25) 2014; 15 Catalina A Vallejos (1874_CR1) 2017; 14 PV Kharchenko (1874_CR13) 2014; 11 S Anders (1874_CR23) 2010; 11 Valentine Svensson (1874_CR5) 2017; 14 T Stuart (1874_CR18) 2019; 177 ATL Lun (1874_CR20) 2016; 5 1874_CR39 D Grün (1874_CR14) 2014; 11 K Shekhar (1874_CR32) 2016; 5 ATL Lun (1874_CR8) 2016; 17 R Lopez (1874_CR10) 2018; 15 X Qiu (1874_CR11) 2017; 14 FA Wolf (1874_CR19) 2018; 19 A Butler (1874_CR17) 2018; 36 G Finak (1874_CR21) 2015; 16 N Eling (1874_CR27) 2018; 7 MI Love (1874_CR12) 2014; 15 L McInnes (1874_CR37) 2018; 3 1874_CR2 1874_CR3 G Eraslan (1874_CR15) 2019; 10 1874_CR29 F Buettner (1874_CR31) 2015; 33 Rahul Satija (1874_CR16) 2015; 33 SJ Sheather (1874_CR26) 1991; 53 MD Robinson (1874_CR28) 2010; 26 M Stoeckius (1874_CR33) 2017; 14 SC Hicks (1874_CR4) 2017; 19 |
| References_xml | – volume: 40 start-page: 4288 issue: 10 year: 2012 ident: 1874_CR22 publication-title: Nucleic Acids Res doi: 10.1093/nar/gks042 – volume: 15 start-page: R29 issue: 2 year: 2014 ident: 1874_CR25 publication-title: Genome Biol doi: 10.1186/gb-2014-15-2-r29 – volume: 11 start-page: 740 issue: 7 year: 2014 ident: 1874_CR13 publication-title: Nat Methods doi: 10.1038/nmeth.2967 – volume: 10 start-page: 390 issue: 1 year: 2019 ident: 1874_CR15 publication-title: Nat Commun doi: 10.1038/s41467-018-07931-2 – volume: 3 start-page: 861 issue: 29 year: 2018 ident: 1874_CR36 publication-title: Journal of Open Source Software doi: 10.21105/joss.00861 – ident: 1874_CR38 – volume: 14 start-page: 309 issue: 3 year: 2017 ident: 1874_CR11 publication-title: Nat Methods doi: 10.1038/nmeth.4150 – volume: 36 start-page: 411 issue: 5 year: 2018 ident: 1874_CR17 publication-title: Nat Biotechnol doi: 10.1038/nbt.4096 – volume: 3 start-page: 861 issue: 29 year: 2018 ident: 1874_CR37 publication-title: J Open Source Softw doi: 10.21105/joss.00861 – ident: 1874_CR29 – volume: 5 start-page: 1308 year: 2016 ident: 1874_CR32 publication-title: 166 – volume: 17 start-page: 1 issue: 1 year: 2016 ident: 1874_CR8 publication-title: Genome Biol doi: 10.1186/s13059-015-0866-z – volume: 7 start-page: 284 issue: 3 year: 2018 ident: 1874_CR27 publication-title: Cell Syst doi: 10.1016/j.cels.2018.06.011 – volume: 33 start-page: 155 issue: 2 year: 2015 ident: 1874_CR31 publication-title: Nat Biotechnol doi: 10.1038/nbt.3102 – volume: 14 start-page: 865 year: 2017 ident: 1874_CR33 publication-title: Nat Methods doi: 10.1038/nmeth.4380 – ident: 1874_CR3 – volume: 11 start-page: 637 issue: 6 year: 2014 ident: 1874_CR14 publication-title: Nat Methods doi: 10.1038/nmeth.2930 – volume: 14 start-page: 687 issue: 7 year: 2017 ident: 1874_CR24 publication-title: Nature Methods doi: 10.1038/nmeth.4324 – volume: 9 start-page: 1 issue: 1 year: 2018 ident: 1874_CR9 publication-title: Nat Commun doi: 10.1038/s41467-017-02554-5 – volume: 15 start-page: 1053 issue: 12 year: 2018 ident: 1874_CR10 publication-title: Nat Methods doi: 10.1038/s41592-018-0229-2 – volume: 5 start-page: 2122 year: 2016 ident: 1874_CR20 publication-title: F1000Research – volume: 14 start-page: 381 issue: 4 year: 2017 ident: 1874_CR5 publication-title: Nature Methods doi: 10.1038/nmeth.4220 – ident: 1874_CR39 – volume: 11 start-page: R106 issue: 10 year: 2010 ident: 1874_CR23 publication-title: Genome Biol doi: 10.1186/gb-2010-11-10-r106 – volume: 53 start-page: 683 issue: 3 year: 1991 ident: 1874_CR26 publication-title: J R Stat Soc Ser B Methodol doi: 10.1111/j.2517-6161.1991.tb01857.x – volume: 14 start-page: 565 issue: 6 year: 2017 ident: 1874_CR1 publication-title: Nature Methods doi: 10.1038/nmeth.4292 – ident: 1874_CR2 doi: 10.1038/nrg3833 – volume: 19 start-page: 1 issue: 1 year: 2018 ident: 1874_CR19 publication-title: Genome Biol doi: 10.1186/s13059-017-1382-0 – volume: 16 start-page: 278 issue: 1 year: 2015 ident: 1874_CR21 publication-title: Genome Biol doi: 10.1186/s13059-015-0844-5 – ident: 1874_CR34 doi: 10.1038/nature14590 – volume: 8 start-page: 4847 issue: 1 year: 2018 ident: 1874_CR35 publication-title: Sci Rep doi: 10.1038/s41598-018-22297-7 – volume: 177 start-page: 1888 issue: 7 year: 2019 ident: 1874_CR18 publication-title: Cell doi: 10.1016/j.cell.2019.05.031 – volume: 15 start-page: 550 issue: 12 year: 2014 ident: 1874_CR12 publication-title: Genome Biol doi: 10.1186/s13059-014-0550-8 – volume: 26 start-page: 139 issue: 1 year: 2010 ident: 1874_CR28 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 – volume: 3 start-page: Article3 issue: 1 year: 2004 ident: 1874_CR30 publication-title: Stat Appl Genet Mol Biol doi: 10.2202/1544-6115.1027 – volume: 14 start-page: 584 issue: 6 year: 2017 ident: 1874_CR6 publication-title: Nat Methods doi: 10.1038/nmeth.4263 – volume: 11 start-page: 1 issue: 6 year: 2015 ident: 1874_CR7 publication-title: PLoS Comput Biol doi: 10.1371/journal.pcbi.1004333 – volume: 19 start-page: 562 issue: 4 year: 2017 ident: 1874_CR4 publication-title: Biostatistics doi: 10.1093/biostatistics/kxx053 – volume: 33 start-page: 495 issue: 5 year: 2015 ident: 1874_CR16 publication-title: Nature Biotechnology doi: 10.1038/nbt.3192 |
| SSID | ssj0019426 ssj0017866 |
| Score | 2.7380521 |
| Snippet | Single-cell RNA-seq (scRNA-seq) data exhibits significant cell-to-cell variation due to technical factors, including the number of molecules detected in each... Abstract Single-cell RNA-seq (scRNA-seq) data exhibits significant cell-to-cell variation due to technical factors, including the number of molecules detected... |
| SourceID | doaj pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 296 |
| SubjectTerms | Animal Genetics and Genomics binomial distribution Bioinformatics Biomedical and Life Sciences data collection Datasets Evolutionary Biology Gene expression gene expression regulation Generalized linear models genes Genomics Human Genetics Humans Life Sciences linear models Method Microbial Genetics and Genomics Normalization Plant Genetics and Genomics Regression Analysis Ribonucleic acid RNA sequence analysis Sequence Analysis, RNA Single-Cell Analysis Single-cell RNA-seq Software variance |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lj9QwDI7QCiQuiDeFBQWJEyjaaZvncUGsOI0Q2sPeojyXkYYOTGdXgl-PnWYGhsdy4dJD4qqp7cR24nwm5EUKSWUdFGtDSIwLY5iX8Aid07xTXVJtKMUm1Hyuz87M-59KfWFO2AQPPDHuSHqvUxap94HzIJPmyfmQs2qFVzwUnM-ZMttgqp4fGDA89Qyz1fJohJVaYF6QYViDjrV7VqiA9f_Jw_w9UfKX09JihE5uk1vVe6TH06jvkGtpuEtuTPUkv94j4xw90GW9WkndEOklxMIoWApeIObB1q5VprhJsEwMd-7ph_kxG9MXivmiFFPhz-m6FKlfL76lSId0XvDBKYTRq0-gsdg7JdAO98npydvTN-9YrarAglKzDQtSi9zNctTcO22i0X1vnFO6j9F54GUIXIgYtM_RaQeRd-xzFFmbJMBd6x-Qg2E1pEeEGgilBDQrDzFdArnkHHMvojcyy-BMQ2ZbJttQEcex8MXSlshDSzvJxYJcLMrFtg15uXvl8wS3cRXxa5TcjhCRsksD6I-t-mP_pT8NOdzK3dbpO9oObHurwZWFbzzfdcPEQ5m4Ia0ukAasP-KqyitouIL1G68PN-ThpEq70cJiqjApqSFqT8n2fme_Z1h8LADg0nTgUsDYXm3V8cfQ_8qtx_-DW0_Iza7Moo51_SE52Kwv0lNyPVxuFuP6WZmD3wGcSTrC priority: 102 providerName: Directory of Open Access Journals – databaseName: SpringerLINK Contemporary 1997-Present dbid: RSV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZQAYlLedNAQUbiBLLYOPHrWBAVpxUqFerN8nNZaUkg2VaCX8_YeaCFUgkuOdgTZWLP2N94xjMIvQguiCidIKVzgdRMKWI5PBw1sqaCBlG6XGxCLJfy7Ex9GO9x91O0--SSzCt1VmvJX_ew2rIU26NIqiNHwOS5DrudTPUaTj5-ml0HCvac0X156Ws7G1DO038ZuPwzRvI3R2nef45v_xfnd9D-CDfx0SAfd9G10NxDN4cClN_vo36ZIOtmvIuJTePxBRjPSRIwwMYUODt2tRGnU4VNIOmoH58sj0gfvuEUYIpT7PwKd7mqfbf-ETxuwionFMdgd7dfQMRT7xBx2zxAp8fvTt--J2MZBuKEWGyJ45JFuohe1tZI5ZWsKmWMkJX3xtKFcK5mzDtpozfSgKnuq-hZlCowwHfVQ7TXtE04QFiB7cWgWVgwAkMdTIw-VsxbxSN3RhVoMU2NdmOK8lQpY6OzqSK5HoZSw1DqNJS6LNDL-ZWvQ36Oq4jfpPmeCVNq7dzQdis9aqrm1soQWaisq2vHgwQ-rYtRlMyK2lUFOpykRY_63msKYKCUgH3hG8_nbtDUNCemCe15ogG4kBKx8itoagELfrpvXKBHgwDO3MLqK1IUU4HEjmju_M5uT7P-nDOGc0UBgwBvryYB_cX6X0fr8T9RP0G3aJZwSmh1iPa23Xl4im64i-26755lFf0JRl88XQ priority: 102 providerName: Springer Nature |
| Title | Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression |
| URI | https://link.springer.com/article/10.1186/s13059-019-1874-1 https://www.ncbi.nlm.nih.gov/pubmed/31870423 https://www.proquest.com/docview/2341180571 https://www.proquest.com/docview/2330331096 https://www.proquest.com/docview/2477632399 https://pubmed.ncbi.nlm.nih.gov/PMC6927181 https://doaj.org/article/6bb8ef5e3bc44c6e84eabcff715b74c3 |
| Volume | 20 |
| WOSCitedRecordID | wos000511887800004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVADU databaseName: BioMed Central customDbUrl: eissn: 1474-760X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017866 issn: 1474-760X databaseCode: RBZ dateStart: 20000101 isFulltext: true titleUrlDefault: https://www.biomedcentral.com/search/ providerName: BioMedCentral – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1474-760X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0019426 issn: 1474-760X databaseCode: DOA dateStart: 20000101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1474-760X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0019426 issn: 1474-760X databaseCode: M7P dateStart: 20150101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1474-760X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0019426 issn: 1474-760X databaseCode: 7X7 dateStart: 20150101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1474-760X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0019426 issn: 1474-760X databaseCode: BENPR dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1474-760X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0019426 issn: 1474-760X databaseCode: PIMPY dateStart: 20150101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVAVX databaseName: SpringerLINK Contemporary 1997-Present customDbUrl: eissn: 1474-760X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0019426 issn: 1474-760X databaseCode: RSV dateStart: 20000201 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LbxMxELZoCxIX3o9AiYzECWQ1612v7RNqUCs4EEWhQoHLatePECnsttm0Evx6ZrxOqvDIhYultR3Jzjw84_k8Q8grZ5z0ykiWGONYJrRmVQ6N4aXKuOROJiYUm5CjkZpO9TheuLURVrnWiUFR28bgHfkRB3WbKLAukrfnFwyrRmF0NZbQ2CMHmCWBB-jeeBNFkAptlfihM949NUIAotB5DHEmKj9qQZELhA1phiXqWLJ1SIVc_n8zQP_EUf4WTA1n1Ond_93dPXInWqf0uGOn--SGqx-QW129yh8PSTtCC3cRn27Ssrb0CnxtZBwKVibibONQ4yleQiwcw8gAnYyOWesuKOJRKULtZ3TpZoiAnf90ltZuFvKPU3DTm-8gETjaAXTrR-Ts9OTs3XsWqzYwI-VgxUyuhOcDb1VWlUpbrdJUl6VUqbVlxQfSmEwIa1TlbalK8Oxt6q3wSjsB5mD6mOzXTe2eEqrBVRPQLSvwGV3mSu-tT4WtdO5zU-oeGaypVJiY0RwLayyK4NmovOgIWwBhCyRskfTI681Pzrt0HrsmD5H0m4mYiTt0NMtZEQW7yKtKOS9cWpksM7lTsM7KeC8TUcnMpD1yuKZ4EdVDW1yTu0deboZBsJEmZe2aS5wD1gXmbc13zMkknA_4PLlHnnS8uFktKGuJoKcekVtcurWd7ZF6_i0kGM81B5MF1vZmzc_XS__nv_Vs90afk9s8CBhnPD0k-6vlpXtBbpqr1bxd9smenMrQqj45GJ6MxpN-uB7pB4mGvvGHj-Mv8DUZfsX20-df6-RTnQ |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Jb9QwFLaqFgQX9iVQwEhwAVmdOHFsHxAqS9VR29EIzaGcLK_DSKNMO5kWlf_Ef8Qvy1TDMrceuERK7Eh28r3Nb0PolbeeB2E5Sa31JGdSElPEi6Va5JRTz1NbN5vgg4E4PpbDDfSzy4WBsMqOJ9aM2s0snJHv0MhuUxG1i_T9ySmBrlHgXe1aaDSwOPAX36PJVr3rf4r_9zWle59HH_dJ21WAWM57C2ILwQLtBSdyo4V0UmSZ1JqLzDltaI9bmzPmrDDBaaGj5emy4FgQ0jNRN4mIHH8rB6xvoq1h_2j4dem24AKUo_ZG5rTJbYKIRyaL1qeaimKnipKDQZySJNATj6QrUrFuHvA3jffPwM3fvLe1UNy7_Z99zjvoVqt9492GXO6iDV_eQ9ebfpwX91E1AA1-2qamYl06fK7ncOzjcdSiIY64HZoFDIcsU0_A84G_DHZJ5U8xxNtiSCUY47kfQ4Tv5Id3uPTjur46NhPIAo8riKNNAHL5AI2uYsMP0WY5K_1jhGU0RVl8zE20iX3udQguZMwZWYTCapmgXgcKZduK7dA4ZKpqy00UqsGRijhSgCOVJujN8pWTplzJuskfAGnLiVBpvH4wm49Vy7hUYYzwgfnM2Dy3hRdxncaGwFNmeG6zBG13AFMt-6vUJboS9HI5HBkX_BNd-tkZzInaE9SlLdbMyXmUf5B-naBHDfSXq43CiENQV4L4ClGsbGd1pJx8qwuoF5JGlSyu7W1HPpdL_-fXerJ-oy_Qjf3R0aE67A8OnqKbtKZtSmi2jTYX8zP_DF2z54tJNX_eMg2M1BXT1S9FzawL |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Zb9QwELZQOcQL9xEoYCSeQFY3h2P7sRwrEGhVQYX6ZvlcVlqSkmwrwa9nJhdaKJUQL3mwJ4qPsf1N5vMMIc-CCyJKJ1jqXGAFV4rZEh4uM7LIRBZE6rpkE2KxkEdH6mDIc9qObPfRJdnfacAoTdVm79jHfonLcq-FnZcjz0cxzCnHwPy5WCCPHs31T58nN4KC82dwZZ752tZh1MXsPwto_smX_M1p2p1F8-v_3Ysb5NoAQ-l-rzc3yYVQ3SKX-8SU32-TdoFQdj3c0aSm8vQUjGrUEApwEgm1Q1UdKf5tWAeGLgD6cbHP2vCNIvGUIqd-SZsu232z-hE8rcKyCzROwR6vv4LqY23PxK3ukMP5m8NXb9mQnoE5IWYb5krJYzaLXhbWSOWVzHNljJC598ZmM-Fcwbl30kZvpAET3ufR8yhV4ID78rtkp6qrcJ9QBTYZh2JhwTgMRTAx-phzb1UZS2dUQmbjNGk3hC7HDBpr3ZkwstT9UGoYSo1DqdOEPJ9eOe7jdpwn_BLnfhLEkNtdQd0s9bCCdWmtDJGH3LqicGWQ0E7rYhQpt6JweUJ2R83Rwz7Q6gxAQioBE8M3nk7VsIJxTkwV6hOUARiBAVrLc2QKAQcB3kNOyL1eGafWwq4skN2UELGlplvd2a6pVl-6SOKlygCbQNtejMr6q-l_Ha0H_yT9hFw5eD3XH94t3j8kV7NO2TOW5btkZ9OchEfkkjvdrNrmcbdyfwK3l0gl |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Normalization+and+variance+stabilization+of+single-cell+RNA-seq+data+using+regularized+negative+binomial+regression&rft.jtitle=Genome+Biology&rft.au=Hafemeister%2C+Christoph&rft.au=Satija%2C+Rahul&rft.date=2019-12-23&rft.pub=Springer+Nature+B.V&rft.issn=1474-7596&rft.eissn=1474-760X&rft.volume=20&rft.spage=1&rft_id=info:doi/10.1186%2Fs13059-019-1874-1 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1474-760X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1474-760X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1474-760X&client=summon |