Tuberculosis, COVID-19 and migrants: Preliminary analysis of deaths occurring in 69 patients from two cohorts

Little is known about the relationship between the COVID-19 and tuberculosis (TB). The aim of this study is to describe a group of patients who died with TB (active disease or sequelae) and COVID-19 in two cohorts. Data from 49 consecutive cases in 8 countries (cohort A) and 20 hospitalised patients...

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Published in:	Pediatric pulmonology Vol. 26; no. 4; pp. 233 - 240
Main Authors:	Motta, I., Centis, R., D’Ambrosio, L., García-García, J.-M., Goletti, D., Gualano, G., Lipani, F., Palmieri, F., Sánchez-Montalvá, A., Pontali, E., Sotgiu, G., Spanevello, A., Stochino, C., Tabernero, E., Tadolini, M., van den Boom, M., Villa, S., Visca, D., Migliori, G.B.
Format:	Journal Article
Language:	English
Published:	Spain Elsevier España, S.L.U 01.07.2020 Informa UK Limited Wiley Sociedade Portuguesa de Pneumologia. Published by Elsevier España, S.L.U Taylor & Francis Group
Subjects:	[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology Adult Age Distribution Aged Aged, 80 and over Antimalarials Antimalarials - therapeutic use Antitubercular Agents Antitubercular Agents - therapeutic use Betacoronavirus Cohort Studies Coinfection Coinfection - mortality Coronavirus Infections Coronavirus Infections - complications Coronavirus Infections - mortality Coronavirus Infections - therapy COVID-19 COVID-19; Infection control; Migrants; Mortality; Sequelae; TB; Adult; Age Distribution; Aged; Aged, 80 and over; Antimalarials; Antitubercular Agents; Betacoronavirus; Cohort Studies; Coinfection; Coronavirus Infections; Female; Humans; Hydroxychloroquine; Length of Stay; Male; Middle Aged; Noninvasive Ventilation; Oxygen Inhalation Therapy; Pandemics; Pneumonia, Viral; Retrospective Studies; Transients and Migrants; Tuberculosis, Pulmonary COVID-19; Infection control; Migrants; Mortality; Sequelae; TB; Adult; Age Distribution; Aged; Aged, 80 and over; Antimalarials; Antitubercular Agents; Betacoronavirus; COVID-19; Cohort Studies; Coinfection; Coronavirus Infections; Female; Humans; Hydroxychloroquine; Length of Stay; Male; Middle Aged; Noninvasive Ventilation; Oxygen Inhalation Therapy; Pandemics; Pneumonia, Viral; Retrospective Studies; SARS-CoV-2; Transients and Migrants; Tuberculosis, Pulmonary COVID-19; TB; infection control; migrants; mortality; sequelae Diseases of the respiratory system Female Human health and pathology Humans Hydroxychloroquine Hydroxychloroquine - therapeutic use Infection control Length of Stay Life Sciences Male Middle Aged Migrants Mortality Noninvasive Ventilation Oxygen Inhalation Therapy Pandemics Pneumonia, Viral Pneumonia, Viral - complications Pneumonia, Viral - mortality Pneumonia, Viral - therapy Pulmonary and Respiratory Medicine RC705-779 Retrospective Studies SARS-CoV-2 Sequelae TB TB; COVID-19; Mortality; Migrants; Sequelae; Infection control Transients and Migrants Transients and Migrants - statistics & numerical data Tuberculosis, Pulmonary Tuberculosis, Pulmonary - complications Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - mortality COVID-19 Migrants Sequelae Mortality TB Infection control
ISSN:	2531-0437, 2531-0429, 8755-6863, 2531-0437, 1099-0496
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Summary:	Little is known about the relationship between the COVID-19 and tuberculosis (TB). The aim of this study is to describe a group of patients who died with TB (active disease or sequelae) and COVID-19 in two cohorts. Data from 49 consecutive cases in 8 countries (cohort A) and 20 hospitalised patients with TB and COVID-19 (cohort B) were analysed and patients who died were described. Demographic and clinical variables were retrospectively collected, including co-morbidities and risk factors for TB and COVID-19 mortality. Overall, 8 out of 69 (11.6%) patients died, 7 from cohort A (14.3%) and one from cohort B (5%). Out of 69 patients 43 were migrants, 26/49 (53.1%) in cohort A and 17/20 (85.0%) in cohort B. Migrants: (1) were younger than natives; in cohort A the median (IQR) age was 40 (27–49) VS. 66 (46–70) years, whereas in cohort B 37 (27–46) VS. 48 (47–60) years; (2) had a lower mortality rate than natives (1/43, 2.3% versus 7/26, 26.9%; p-value: 0.002); (3) had fewer co-morbidities than natives (23/43, 53.5% versus 5/26–19.2%) natives; p-value: 0.005). The study findings show that: (1) mortality is likely to occur in elderly patients with co-morbidities; (2) TB might not be a major determinant of mortality and (3) migrants had lower mortality, probably because of their younger age and lower number of co-morbidities. However, in settings where advanced forms of TB frequently occur and are caused by drug-resistant strains of M. tuberculosis, higher mortality rates can be expected in young individuals.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2531-0437 2531-0429 8755-6863 2531-0437 1099-0496
DOI:	10.1016/j.pulmoe.2020.05.002