Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits

The obesity epidemic is responsible for a substantial economic burden in developed countries and is a major risk factor for type 2 diabetes and cardiovascular disease. The disease is the result not only of several environmental risk factors, but also of genetic predisposition. To take advantage of r...

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Vydáno v:	PLoS genetics Ročník 3; číslo 7; s. e115
Hlavní autoři:	Scuteri, Angelo, Sanna, Serena, Chen, Wei-Min, Uda, Manuela, Albai, Giuseppe, Strait, James, Najjar, Samer, Nagaraja, Ramaiah, Orrú, Marco, Usala, Gianluca, Dei, Mariano, Lai, Sandra, Maschio, Andrea, Busonero, Fabio, Mulas, Antonella, Ehret, Georg B, Fink, Ashley A, Weder, Alan B, Cooper, Richard S, Galan, Pilar, Chakravarti, Aravinda, Schlessinger, David, Cao, Antonio, Lakatta, Edward, Abecasis, Gonçalo R
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 01.07.2007 Public Library of Science (PLoS)
Témata:	Adiposity - genetics Adolescent Adult Aged Aged, 80 and over Aging Alleles Alpha-Ketoglutarate-Dependent Dioxygenase FTO Body Mass Index Body Weight - genetics Chromosome mapping Diabetes and Endocrinology Female Genes Genetic aspects Genetic Predisposition to Disease Genetic Variation Genetics Genetics and Genomics Genome, Human Genomes Homo (Human) Humans Influence Linkage Disequilibrium Male Middle Aged Obesity Obesity - genetics Obesity - pathology Obesity gene Phosphofructokinases - genetics Polymorphism, Single Nucleotide Proteins - genetics Quantitative Trait Loci Scanning devices United States
ISSN:	1553-7404, 1553-7390, 1553-7404
On-line přístup:	Získat plný text
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