Advances in clinical trial design for development of new TB treatments—Translating international tuberculosis treatment guidelines into national strategic plans: Experiences from Belarus, South Africa, and Vietnam

About the Authors: Grania Brigden * E-mail: grania.brigden@theunion.org Affiliation: Department of Tuberculosis, The International Union Against TB and Lung Disease, Geneva, Switzerland ORCID logo http://orcid.org/0000-0001-5184-4121 Nguyen Viet Nhung Affiliation: National Lung Hospital, Vietnam NTP...

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Published in:PLoS medicine Vol. 16; no. 10; p. e1002896
Main Authors: Brigden, Grania, Nhung, Nguyen Viet, Skrahina, Alena, Ndjeka, Norbert, Falzon, Dennis, Zignol, Matteo
Format: Journal Article
Language:English
Published: United States Public Library of Science 18.10.2019
Public Library of Science (PLoS)
Subjects:
Bedaquiline
Clinical trials
Clinical Trials as Topic - standards
Collection Review
Communicable Disease Control - standards
Diarylquinolines - administration & dosage
Drug Administration Schedule
Drug resistance
Drug therapy
Global Health
Health Policy
HIV
HIV Infections - complications
HIV Infections - therapy
Human immunodeficiency virus
Humans
International Cooperation
Internet
Lung diseases
Medical personnel
Medicine and Health Sciences
Operations research
Patients
People and Places
Practice guidelines (Medicine)
Practice Guidelines as Topic
Public Health
Public health movements
Republic of Belarus - epidemiology
Research Design - standards
South Africa - epidemiology
Strategic planning (Business)
Translational Research, Biomedical - methods
Tuberculosis
Tuberculosis - complications
Tuberculosis - drug therapy
Tuberculosis - epidemiology
Vietnam - epidemiology
Republic of Belarus
South Africa
Vietnam
Belarus
Switzerland
ISSN:1549-1676, 1549-1277, 1549-1676
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Summary:About the Authors: Grania Brigden * E-mail: grania.brigden@theunion.org Affiliation: Department of Tuberculosis, The International Union Against TB and Lung Disease, Geneva, Switzerland ORCID logo http://orcid.org/0000-0001-5184-4121 Nguyen Viet Nhung Affiliation: National Lung Hospital, Vietnam NTP, Vietnam Alena Skrahina Affiliation: Republican Scientific and Practical Centre for Pulmonology and TB, Minsk, Belarus Norbert Ndjeka Affiliation: Drug-Resistant TB, TB and HIV directorate, National Department of Health, Pretoria, South Africa Dennis Falzon Affiliation: Global Tuberculosis Programme, World Health Organization, Geneva, Switzerland ORCID logo http://orcid.org/0000-0001-8798-7909 Matteo Zignol Affiliation: Global Tuberculosis Programme, World Health Organization, Geneva, Switzerland Introduction One of the key missions of national tuberculosis (TB) programmes (NTPs) is to issue policy and technical guidance for clinicians and healthcare workers involved in TB care at the country level. Translating research findings into policies may be a challenging task, given that the design of clinical studies may not always address the main public health priority directly, and recommended interventions require substantial adaptation to the particular programme conditions and settings [4]. A recent review [17] of national policies in 29 countries highlighted national policy gaps when compared to WHO policies. [...]in the case of WHO’s recommended 9–12-month-shorter MDR-TB regimen, 45% of the countries had developed policies, but only 69% of those countries had implemented them. Since late 2018, the NTP introduced under operational research conditions a shorter regimen of 9 months consisting of all group A and B medicines recommended in MDR-TB regimens.
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The authors have declared that no competing interests exist.
ISSN:1549-1676
1549-1277
1549-1676
DOI:10.1371/journal.pmed.1002896