Vitamin D levels and susceptibility to asthma, elevated immunoglobulin E levels, and atopic dermatitis: A Mendelian randomization study

Low circulating vitamin D levels have been associated with risk of asthma, atopic dermatitis, and elevated total immunoglobulin E (IgE). These epidemiological associations, if true, would have public health importance, since vitamin D insufficiency is common and correctable. We aimed to test whether...

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Bibliographic Details
Published in:	PLoS medicine Vol. 14; no. 5; p. e1002294
Main Authors:	Manousaki, Despoina, Paternoster, Lavinia, Standl, Marie, Moffatt, Miriam F., Farrall, Martin, Bouzigon, Emmanuelle, Strachan, David P., Demenais, Florence, Lathrop, Mark, Cookson, William O. C. M., Richards, J. Brent
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 09.05.2017 Public Library of Science (PLoS)
Subjects:	25-Hydroxyvitamin D Adult Asthma Asthma - chemically induced Asthma - epidemiology Atopic dermatitis Bias Biology and Life Sciences Causality Causation Child Children Consortia Dermatitis Dermatitis, Atopic - chemically induced Dermatitis, Atopic - epidemiology Disease Eczema Epidemiology Genome-Wide Association Study Genomes Health aspects Humans Immunoglobulin E Immunoglobulin E - blood Immunoglobulins Medical research Medicine Medicine and Health Sciences Mendelian Randomization Analysis Meta-analysis Metabolism Pediatrics Physical sciences Pleiotropy Polymorphism, Single Nucleotide Prevention Public health Randomization Research and Analysis Methods Retrospective Studies Risk Factors Sensitivity Single-nucleotide polymorphism Skin diseases Social Sciences Standard deviation Studies Sunlight Test procedures Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood
ISSN:	1549-1676, 1549-1277, 1549-1676
Online Access:	Get full text
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