Vitamin D levels and risk of type 1 diabetes: A Mendelian randomization study

Vitamin D deficiency has been associated with type 1 diabetes in observational studies, but evidence from randomized controlled trials (RCTs) is lacking. The aim of this study was to test whether genetically decreased vitamin D levels are causally associated with type 1 diabetes using Mendelian rand...

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Bibliographic Details
Published in:	PLoS medicine Vol. 18; no. 2; p. e1003536
Main Authors:	Manousaki, Despoina, Harroud, Adil, Mitchell, Ruth E., Ross, Stephanie, Forgetta, Vince, Timpson, Nicholas J., Smith, George Davey, Polychronakos, Constantin, Richards, J Brent
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 25.02.2021 Public Library of Science (PLoS)
Subjects:	Biology and Life Sciences Biomarkers Causality Clinical trials Complications and side effects Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - etiology Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 2 - complications Epidemiology Genetic aspects Genetic diversity Genetic variance Genome-wide association studies Genome-Wide Association Study Genomes Health care Humans Hypotheses Immune system Medicine and Health Sciences Mendelian Randomization Analysis - methods Phenotype Physical sciences Polymorphism, Single Nucleotide - genetics Research and Analysis Methods Risk Factors Single-nucleotide polymorphism Type 1 diabetes Ultraviolet radiation Vitamin D Vitamin D - blood Vitamin D deficiency Vitamin D Deficiency - blood Vitamin D Deficiency - genetics Vitamin deficiency Canada
ISSN:	1549-1676, 1549-1277, 1549-1676
Online Access:	Get full text
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