Advance care planning in patients with advanced cancer: A 6-country, cluster-randomised clinical trial
Advance care planning (ACP) supports individuals to define, discuss, and record goals and preferences for future medical treatment and care. Despite being internationally recommended, randomised clinical trials of ACP in patients with advanced cancer are scarce. To test the implementation of ACP in...
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| Published in: | PLoS medicine Vol. 17; no. 11; p. e1003422 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Public Library of Science
13.11.2020
Public Library of Science (PLoS) |
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| ISSN: | 1549-1676, 1549-1277, 1549-1676 |
| Online Access: | Get full text |
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| Abstract | Advance care planning (ACP) supports individuals to define, discuss, and record goals and preferences for future medical treatment and care. Despite being internationally recommended, randomised clinical trials of ACP in patients with advanced cancer are scarce.
To test the implementation of ACP in patients with advanced cancer, we conducted a cluster-randomised trial in 23 hospitals across Belgium, Denmark, Italy, Netherlands, Slovenia, and United Kingdom in 2015-2018. Patients with advanced lung (stage III/IV) or colorectal (stage IV) cancer, WHO performance status 0-3, and at least 3 months life expectancy were eligible. The ACTION Respecting Choices ACP intervention as offered to patients in the intervention arm included scripted ACP conversations between patients, family members, and certified facilitators; standardised leaflets; and standardised advance directives. Control patients received care as usual. Main outcome measures were quality of life (operationalised as European Organisation for Research and Treatment of Cancer [EORTC] emotional functioning) and symptoms. Secondary outcomes were coping, patient satisfaction, shared decision-making, patient involvement in decision-making, inclusion of advance directives (ADs) in hospital files, and use of hospital care. In all, 1,117 patients were included (442 intervention; 675 control), and 809 (72%) completed the 12-week questionnaire. Patients' age ranged from 18 to 91 years, with a mean of 66; 39% were female. The mean number of ACP conversations per patient was 1.3. Fidelity was 86%. Sixteen percent of patients found ACP conversations distressing. Mean change in patients' quality of life did not differ between intervention and control groups (T-score -1.8 versus -0.8, p = 0.59), nor did changes in symptoms, coping, patient satisfaction, and shared decision-making. Specialist palliative care (37% versus 27%, p = 0.002) and AD inclusion in hospital files (10% versus 3%, p < 0.001) were more likely in the intervention group. A key limitation of the study is that recruitment rates were lower in intervention than in control hospitals.
Our results show that quality of life effects were not different between patients who had ACP conversations and those who received usual care. The increased use of specialist palliative care and AD inclusion in hospital files of intervention patients is meaningful and requires further study. Our findings suggest that alternative approaches to support patient-centred end-of-life care in this population are needed.
ISRCTN registry ISRCTN63110516. |
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| AbstractList | Advance care planning (ACP) supports individuals to define, discuss, and record goals and preferences for future medical treatment and care. Despite being internationally recommended, randomised clinical trials of ACP in patients with advanced cancer are scarce.BACKGROUNDAdvance care planning (ACP) supports individuals to define, discuss, and record goals and preferences for future medical treatment and care. Despite being internationally recommended, randomised clinical trials of ACP in patients with advanced cancer are scarce.To test the implementation of ACP in patients with advanced cancer, we conducted a cluster-randomised trial in 23 hospitals across Belgium, Denmark, Italy, Netherlands, Slovenia, and United Kingdom in 2015-2018. Patients with advanced lung (stage III/IV) or colorectal (stage IV) cancer, WHO performance status 0-3, and at least 3 months life expectancy were eligible. The ACTION Respecting Choices ACP intervention as offered to patients in the intervention arm included scripted ACP conversations between patients, family members, and certified facilitators; standardised leaflets; and standardised advance directives. Control patients received care as usual. Main outcome measures were quality of life (operationalised as European Organisation for Research and Treatment of Cancer [EORTC] emotional functioning) and symptoms. Secondary outcomes were coping, patient satisfaction, shared decision-making, patient involvement in decision-making, inclusion of advance directives (ADs) in hospital files, and use of hospital care. In all, 1,117 patients were included (442 intervention; 675 control), and 809 (72%) completed the 12-week questionnaire. Patients' age ranged from 18 to 91 years, with a mean of 66; 39% were female. The mean number of ACP conversations per patient was 1.3. Fidelity was 86%. Sixteen percent of patients found ACP conversations distressing. Mean change in patients' quality of life did not differ between intervention and control groups (T-score -1.8 versus -0.8, p = 0.59), nor did changes in symptoms, coping, patient satisfaction, and shared decision-making. Specialist palliative care (37% versus 27%, p = 0.002) and AD inclusion in hospital files (10% versus 3%, p < 0.001) were more likely in the intervention group. A key limitation of the study is that recruitment rates were lower in intervention than in control hospitals.METHODS AND FINDINGSTo test the implementation of ACP in patients with advanced cancer, we conducted a cluster-randomised trial in 23 hospitals across Belgium, Denmark, Italy, Netherlands, Slovenia, and United Kingdom in 2015-2018. Patients with advanced lung (stage III/IV) or colorectal (stage IV) cancer, WHO performance status 0-3, and at least 3 months life expectancy were eligible. The ACTION Respecting Choices ACP intervention as offered to patients in the intervention arm included scripted ACP conversations between patients, family members, and certified facilitators; standardised leaflets; and standardised advance directives. Control patients received care as usual. Main outcome measures were quality of life (operationalised as European Organisation for Research and Treatment of Cancer [EORTC] emotional functioning) and symptoms. Secondary outcomes were coping, patient satisfaction, shared decision-making, patient involvement in decision-making, inclusion of advance directives (ADs) in hospital files, and use of hospital care. In all, 1,117 patients were included (442 intervention; 675 control), and 809 (72%) completed the 12-week questionnaire. Patients' age ranged from 18 to 91 years, with a mean of 66; 39% were female. The mean number of ACP conversations per patient was 1.3. Fidelity was 86%. Sixteen percent of patients found ACP conversations distressing. Mean change in patients' quality of life did not differ between intervention and control groups (T-score -1.8 versus -0.8, p = 0.59), nor did changes in symptoms, coping, patient satisfaction, and shared decision-making. Specialist palliative care (37% versus 27%, p = 0.002) and AD inclusion in hospital files (10% versus 3%, p < 0.001) were more likely in the intervention group. A key limitation of the study is that recruitment rates were lower in intervention than in control hospitals.Our results show that quality of life effects were not different between patients who had ACP conversations and those who received usual care. The increased use of specialist palliative care and AD inclusion in hospital files of intervention patients is meaningful and requires further study. Our findings suggest that alternative approaches to support patient-centred end-of-life care in this population are needed.CONCLUSIONSOur results show that quality of life effects were not different between patients who had ACP conversations and those who received usual care. The increased use of specialist palliative care and AD inclusion in hospital files of intervention patients is meaningful and requires further study. Our findings suggest that alternative approaches to support patient-centred end-of-life care in this population are needed.ISRCTN registry ISRCTN63110516.TRIAL REGISTRATIONISRCTN registry ISRCTN63110516. Advance care planning (ACP) supports individuals to define, discuss, and record goals and preferences for future medical treatment and care. Despite being internationally recommended, randomised clinical trials of ACP in patients with advanced cancer are scarce. To test the implementation of ACP in patients with advanced cancer, we conducted a cluster-randomised trial in 23 hospitals across Belgium, Denmark, Italy, Netherlands, Slovenia, and United Kingdom in 2015-2018. Patients with advanced lung (stage III/IV) or colorectal (stage IV) cancer, WHO performance status 0-3, and at least 3 months life expectancy were eligible. The ACTION Respecting Choices ACP intervention as offered to patients in the intervention arm included scripted ACP conversations between patients, family members, and certified facilitators; standardised leaflets; and standardised advance directives. Control patients received care as usual. Main outcome measures were quality of life (operationalised as European Organisation for Research and Treatment of Cancer [EORTC] emotional functioning) and symptoms. Secondary outcomes were coping, patient satisfaction, shared decision-making, patient involvement in decision-making, inclusion of advance directives (ADs) in hospital files, and use of hospital care. In all, 1,117 patients were included (442 intervention; 675 control), and 809 (72%) completed the 12-week questionnaire. Patients' age ranged from 18 to 91 years, with a mean of 66; 39% were female. The mean number of ACP conversations per patient was 1.3. Fidelity was 86%. Sixteen percent of patients found ACP conversations distressing. Mean change in patients' quality of life did not differ between intervention and control groups (T-score -1.8 versus -0.8, p = 0.59), nor did changes in symptoms, coping, patient satisfaction, and shared decision-making. Specialist palliative care (37% versus 27%, p = 0.002) and AD inclusion in hospital files (10% versus 3%, p < 0.001) were more likely in the intervention group. A key limitation of the study is that recruitment rates were lower in intervention than in control hospitals. Our results show that quality of life effects were not different between patients who had ACP conversations and those who received usual care. The increased use of specialist palliative care and AD inclusion in hospital files of intervention patients is meaningful and requires further study. Our findings suggest that alternative approaches to support patient-centred end-of-life care in this population are needed. Background Advance care planning (ACP) supports individuals to define, discuss, and record goals and preferences for future medical treatment and care. Despite being internationally recommended, randomised clinical trials of ACP in patients with advanced cancer are scarce. Methods and findings To test the implementation of ACP in patients with advanced cancer, we conducted a cluster-randomised trial in 23 hospitals across Belgium, Denmark, Italy, Netherlands, Slovenia, and United Kingdom in 2015-2018. Patients with advanced lung (stage III/IV) or colorectal (stage IV) cancer, WHO performance status 0-3, and at least 3 months life expectancy were eligible. The ACTION Respecting Choices ACP intervention as offered to patients in the intervention arm included scripted ACP conversations between patients, family members, and certified facilitators; standardised leaflets; and standardised advance directives. Control patients received care as usual. Main outcome measures were quality of life (operationalised as European Organisation for Research and Treatment of Cancer [EORTC] emotional functioning) and symptoms. Secondary outcomes were coping, patient satisfaction, shared decision-making, patient involvement in decision-making, inclusion of advance directives (ADs) in hospital files, and use of hospital care. In all, 1,117 patients were included (442 intervention; 675 control), and 809 (72%) completed the 12-week questionnaire. Patients' age ranged from 18 to 91 years, with a mean of 66; 39% were female. The mean number of ACP conversations per patient was 1.3. Fidelity was 86%. Sixteen percent of patients found ACP conversations distressing. Mean change in patients' quality of life did not differ between intervention and control groups (T-score -1.8 versus -0.8, p = 0.59), nor did changes in symptoms, coping, patient satisfaction, and shared decision-making. Specialist palliative care (37% versus 27%, p = 0.002) and AD inclusion in hospital files (10% versus 3%, p < 0.001) were more likely in the intervention group. A key limitation of the study is that recruitment rates were lower in intervention than in control hospitals. Conclusions Our results show that quality of life effects were not different between patients who had ACP conversations and those who received usual care. The increased use of specialist palliative care and AD inclusion in hospital files of intervention patients is meaningful and requires further study. Our findings suggest that alternative approaches to support patient-centred end-of-life care in this population are needed. Trial registration ISRCTN registry ISRCTN63110516. Advance care planning (ACP) supports individuals to define, discuss, and record goals and preferences for future medical treatment and care. Despite being internationally recommended, randomised clinical trials of ACP in patients with advanced cancer are scarce. To test the implementation of ACP in patients with advanced cancer, we conducted a cluster-randomised trial in 23 hospitals across Belgium, Denmark, Italy, Netherlands, Slovenia, and United Kingdom in 2015-2018. Patients with advanced lung (stage III/IV) or colorectal (stage IV) cancer, WHO performance status 0-3, and at least 3 months life expectancy were eligible. The ACTION Respecting Choices ACP intervention as offered to patients in the intervention arm included scripted ACP conversations between patients, family members, and certified facilitators; standardised leaflets; and standardised advance directives. Control patients received care as usual. Main outcome measures were quality of life (operationalised as European Organisation for Research and Treatment of Cancer [EORTC] emotional functioning) and symptoms. Secondary outcomes were coping, patient satisfaction, shared decision-making, patient involvement in decision-making, inclusion of advance directives (ADs) in hospital files, and use of hospital care. In all, 1,117 patients were included (442 intervention; 675 control), and 809 (72%) completed the 12-week questionnaire. Patients' age ranged from 18 to 91 years, with a mean of 66; 39% were female. The mean number of ACP conversations per patient was 1.3. Fidelity was 86%. Sixteen percent of patients found ACP conversations distressing. Mean change in patients' quality of life did not differ between intervention and control groups (T-score -1.8 versus -0.8, p = 0.59), nor did changes in symptoms, coping, patient satisfaction, and shared decision-making. Specialist palliative care (37% versus 27%, p = 0.002) and AD inclusion in hospital files (10% versus 3%, p < 0.001) were more likely in the intervention group. A key limitation of the study is that recruitment rates were lower in intervention than in control hospitals. Our results show that quality of life effects were not different between patients who had ACP conversations and those who received usual care. The increased use of specialist palliative care and AD inclusion in hospital files of intervention patients is meaningful and requires further study. Our findings suggest that alternative approaches to support patient-centred end-of-life care in this population are needed. ISRCTN registry ISRCTN63110516. BackgroundAdvance care planning (ACP) supports individuals to define, discuss, and record goals and preferences for future medical treatment and care. Despite being internationally recommended, randomised clinical trials of ACP in patients with advanced cancer are scarce.Methods and findingsTo test the implementation of ACP in patients with advanced cancer, we conducted a cluster-randomised trial in 23 hospitals across Belgium, Denmark, Italy, Netherlands, Slovenia, and United Kingdom in 2015-2018. Patients with advanced lung (stage III/IV) or colorectal (stage IV) cancer, WHO performance status 0-3, and at least 3 months life expectancy were eligible. The ACTION Respecting Choices ACP intervention as offered to patients in the intervention arm included scripted ACP conversations between patients, family members, and certified facilitators; standardised leaflets; and standardised advance directives. Control patients received care as usual. Main outcome measures were quality of life (operationalised as European Organisation for Research and Treatment of Cancer [EORTC] emotional functioning) and symptoms. Secondary outcomes were coping, patient satisfaction, shared decision-making, patient involvement in decision-making, inclusion of advance directives (ADs) in hospital files, and use of hospital care. In all, 1,117 patients were included (442 intervention; 675 control), and 809 (72%) completed the 12-week questionnaire. Patients' age ranged from 18 to 91 years, with a mean of 66; 39% were female. The mean number of ACP conversations per patient was 1.3. Fidelity was 86%. Sixteen percent of patients found ACP conversations distressing. Mean change in patients' quality of life did not differ between intervention and control groups (T-score -1.8 versus -0.8, p = 0.59), nor did changes in symptoms, coping, patient satisfaction, and shared decision-making. Specialist palliative care (37% versus 27%, p = 0.002) and AD inclusion in hospital files (10% versus 3%, p < 0.001) were more likely in the intervention group. A key limitation of the study is that recruitment rates were lower in intervention than in control hospitals.ConclusionsOur results show that quality of life effects were not different between patients who had ACP conversations and those who received usual care. The increased use of specialist palliative care and AD inclusion in hospital files of intervention patients is meaningful and requires further study. Our findings suggest that alternative approaches to support patient-centred end-of-life care in this population are needed.Trial registrationISRCTN registry ISRCTN63110516. Giulia Carreras and colleagues report the implementation of advanced care planning in patients with advanced cancer. Background Advance care planning (ACP) supports individuals to define, discuss, and record goals and preferences for future medical treatment and care. Despite being internationally recommended, randomised clinical trials of ACP in patients with advanced cancer are scarce. Methods and findings To test the implementation of ACP in patients with advanced cancer, we conducted a cluster-randomised trial in 23 hospitals across Belgium, Denmark, Italy, Netherlands, Slovenia, and United Kingdom in 2015–2018. Patients with advanced lung (stage III/IV) or colorectal (stage IV) cancer, WHO performance status 0–3, and at least 3 months life expectancy were eligible. The ACTION Respecting Choices ACP intervention as offered to patients in the intervention arm included scripted ACP conversations between patients, family members, and certified facilitators; standardised leaflets; and standardised advance directives. Control patients received care as usual. Main outcome measures were quality of life (operationalised as European Organisation for Research and Treatment of Cancer [EORTC] emotional functioning) and symptoms. Secondary outcomes were coping, patient satisfaction, shared decision-making, patient involvement in decision-making, inclusion of advance directives (ADs) in hospital files, and use of hospital care. In all, 1,117 patients were included (442 intervention; 675 control), and 809 (72%) completed the 12-week questionnaire. Patients’ age ranged from 18 to 91 years, with a mean of 66; 39% were female. The mean number of ACP conversations per patient was 1.3. Fidelity was 86%. Sixteen percent of patients found ACP conversations distressing. Mean change in patients’ quality of life did not differ between intervention and control groups (T-score −1.8 versus −0.8, p = 0.59), nor did changes in symptoms, coping, patient satisfaction, and shared decision-making. Specialist palliative care (37% versus 27%, p = 0.002) and AD inclusion in hospital files (10% versus 3%, p < 0.001) were more likely in the intervention group. A key limitation of the study is that recruitment rates were lower in intervention than in control hospitals. Conclusions Our results show that quality of life effects were not different between patients who had ACP conversations and those who received usual care. The increased use of specialist palliative care and AD inclusion in hospital files of intervention patients is meaningful and requires further study. Our findings suggest that alternative approaches to support patient-centred end-of-life care in this population are needed. Trial registration ISRCTN registry ISRCTN63110516. Background Advance care planning (ACP) supports individuals to define, discuss, and record goals and preferences for future medical treatment and care. Despite being internationally recommended, randomised clinical trials of ACP in patients with advanced cancer are scarce. Methods and findings To test the implementation of ACP in patients with advanced cancer, we conducted a cluster-randomised trial in 23 hospitals across Belgium, Denmark, Italy, Netherlands, Slovenia, and United Kingdom in 2015–2018. Patients with advanced lung (stage III/IV) or colorectal (stage IV) cancer, WHO performance status 0–3, and at least 3 months life expectancy were eligible. The ACTION Respecting Choices ACP intervention as offered to patients in the intervention arm included scripted ACP conversations between patients, family members, and certified facilitators; standardised leaflets; and standardised advance directives. Control patients received care as usual. Main outcome measures were quality of life (operationalised as European Organisation for Research and Treatment of Cancer [EORTC] emotional functioning) and symptoms. Secondary outcomes were coping, patient satisfaction, shared decision-making, patient involvement in decision-making, inclusion of advance directives (ADs) in hospital files, and use of hospital care. In all, 1,117 patients were included (442 intervention; 675 control), and 809 (72%) completed the 12-week questionnaire. Patients’ age ranged from 18 to 91 years, with a mean of 66; 39% were female. The mean number of ACP conversations per patient was 1.3. Fidelity was 86%. Sixteen percent of patients found ACP conversations distressing. Mean change in patients’ quality of life did not differ between intervention and control groups (T-score −1.8 versus −0.8, p = 0.59), nor did changes in symptoms, coping, patient satisfaction, and shared decision-making. Specialist palliative care (37% versus 27%, p = 0.002) and AD inclusion in hospital files (10% versus 3%, p < 0.001) were more likely in the intervention group. A key limitation of the study is that recruitment rates were lower in intervention than in control hospitals. Conclusions Our results show that quality of life effects were not different between patients who had ACP conversations and those who received usual care. The increased use of specialist palliative care and AD inclusion in hospital files of intervention patients is meaningful and requires further study. Our findings suggest that alternative approaches to support patient-centred end-of-life care in this population are needed. Trial registration ISRCTN registry ISRCTN63110516. |
| Audience | Academic |
| Author | Caswell, Glenys Červ, Branka Groenvold, Mogens Toccafondi, Alessandro Carreras, Giulia Lunder, Urska Seymour, Jane Dunleavy, Lesley Thit Johnsen, Anna Billekens, Pascalle Miccinesi, Guido Gorini, Giuseppe Ingravallo, Francesca Arnfeldt Christensen, Caroline M. Bulli, Francesco Polinder, Suzanne Eecloo, Kim Wilcock, Andrew Hammes, Bud Verkissen, Mariëtte N. Simonič, Anja Preston, Nancy J. Bramley, Louise Jabbarian, Lea J. Pollock, Kristian van Delden, Johannes J. M. Deliens, Luc Kodba-Čeh, Hana Kars, Marijke C. van der Heide, Agnes Mimić, Alenka Briggs, Linda Korfage, Ida J. Payne, Sheila A. Rietjens, Judith A. C. Ozbič, Polona Zwakman, Marieke |
| AuthorAffiliation | 12 International Observatory on End of Life Care, Division of Health Research, Lancaster University, Lancaster, United Kingdom UAB, UNITED STATES 4 Department of Palliative Medicine, Research Unit, Bispebjerg Hospital, Copenhagen, Denmark 13 Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy 7 Respecting Choices, C-TAC Innovations, Oregon, Wisconsin, United States of America 6 Institute of Nursing and Midwifery Care Excellence, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom 14 Health Sciences School, University of Sheffield, Sheffield, United Kingdom 9 University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia 3 Department of Public Health, University of Copenhagen, Copenhagen, Denmark 1 Department of Public Health, Erasmus MC, Rotterdam, Netherlands 11 End-of-Life Care Research Group, Vrije Universiteit Brussel and Ghent University, Brussels, Belgium 15 School of Medicine, University of Nottingham, Nottingham, Un |
| AuthorAffiliation_xml | – name: 6 Institute of Nursing and Midwifery Care Excellence, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom – name: 9 University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia – name: 15 School of Medicine, University of Nottingham, Nottingham, United Kingdom – name: UAB, UNITED STATES – name: 1 Department of Public Health, Erasmus MC, Rotterdam, Netherlands – name: 3 Department of Public Health, University of Copenhagen, Copenhagen, Denmark – name: 8 School of Health Sciences, University of Nottingham, Nottingham, United Kingdom – name: 7 Respecting Choices, C-TAC Innovations, Oregon, Wisconsin, United States of America – name: 13 Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy – name: 12 International Observatory on End of Life Care, Division of Health Research, Lancaster University, Lancaster, United Kingdom – name: 4 Department of Palliative Medicine, Research Unit, Bispebjerg Hospital, Copenhagen, Denmark – name: 11 End-of-Life Care Research Group, Vrije Universiteit Brussel and Ghent University, Brussels, Belgium – name: 2 Clinical Epidemiology, Oncological Network, Prevention and Research Institute (ISPRO), Florence, Italy – name: 14 Health Sciences School, University of Sheffield, Sheffield, United Kingdom – name: 5 Laurens, Rotterdam, Netherlands – name: 10 Julius Centre for Health Sciences and Primary Care, UMC Utrecht, Utrecht, Netherlands |
| Author_xml | – sequence: 1 givenname: Ida J. orcidid: 0000-0001-6538-9115 surname: Korfage fullname: Korfage, Ida J. – sequence: 2 givenname: Giulia orcidid: 0000-0002-1427-637X surname: Carreras fullname: Carreras, Giulia – sequence: 3 givenname: Caroline M. surname: Arnfeldt Christensen fullname: Arnfeldt Christensen, Caroline M. – sequence: 4 givenname: Pascalle surname: Billekens fullname: Billekens, Pascalle – sequence: 5 givenname: Louise orcidid: 0000-0002-0425-1734 surname: Bramley fullname: Bramley, Louise – sequence: 6 givenname: Linda surname: Briggs fullname: Briggs, Linda – sequence: 7 givenname: Francesco surname: Bulli fullname: Bulli, Francesco – sequence: 8 givenname: Glenys orcidid: 0000-0002-8246-8189 surname: Caswell fullname: Caswell, Glenys – sequence: 9 givenname: Branka surname: Červ fullname: Červ, Branka – sequence: 10 givenname: Johannes J. M. orcidid: 0000-0002-5530-7275 surname: van Delden fullname: van Delden, Johannes J. M. – sequence: 11 givenname: Luc orcidid: 0000-0002-8158-2422 surname: Deliens fullname: Deliens, Luc – sequence: 12 givenname: Lesley surname: Dunleavy fullname: Dunleavy, Lesley – sequence: 13 givenname: Kim orcidid: 0000-0001-8743-866X surname: Eecloo fullname: Eecloo, Kim – sequence: 14 givenname: Giuseppe orcidid: 0000-0002-1413-5948 surname: Gorini fullname: Gorini, Giuseppe – sequence: 15 givenname: Mogens surname: Groenvold fullname: Groenvold, Mogens – sequence: 16 givenname: Bud orcidid: 0000-0001-5867-1577 surname: Hammes fullname: Hammes, Bud – sequence: 17 givenname: Francesca orcidid: 0000-0002-5194-375X surname: Ingravallo fullname: Ingravallo, Francesca – sequence: 18 givenname: Lea J. orcidid: 0000-0001-6418-162X surname: Jabbarian fullname: Jabbarian, Lea J. – sequence: 19 givenname: Marijke C. orcidid: 0000-0001-5680-4559 surname: Kars fullname: Kars, Marijke C. – sequence: 20 givenname: Hana surname: Kodba-Čeh fullname: Kodba-Čeh, Hana – sequence: 21 givenname: Urska orcidid: 0000-0002-0236-0240 surname: Lunder fullname: Lunder, Urska – sequence: 22 givenname: Guido orcidid: 0000-0002-7452-9594 surname: Miccinesi fullname: Miccinesi, Guido – sequence: 23 givenname: Alenka surname: Mimić fullname: Mimić, Alenka – sequence: 24 givenname: Polona surname: Ozbič fullname: Ozbič, Polona – sequence: 25 givenname: Sheila A. orcidid: 0000-0001-6982-9181 surname: Payne fullname: Payne, Sheila A. – sequence: 26 givenname: Suzanne surname: Polinder fullname: Polinder, Suzanne – sequence: 27 givenname: Kristian orcidid: 0000-0002-6836-8595 surname: Pollock fullname: Pollock, Kristian – sequence: 28 givenname: Nancy J. orcidid: 0000-0003-2659-2342 surname: Preston fullname: Preston, Nancy J. – sequence: 29 givenname: Jane orcidid: 0000-0002-9384-2551 surname: Seymour fullname: Seymour, Jane – sequence: 30 givenname: Anja orcidid: 0000-0002-1884-4522 surname: Simonič fullname: Simonič, Anja – sequence: 31 givenname: Anna orcidid: 0000-0003-0753-9634 surname: Thit Johnsen fullname: Thit Johnsen, Anna – sequence: 32 givenname: Alessandro surname: Toccafondi fullname: Toccafondi, Alessandro – sequence: 33 givenname: Mariëtte N. orcidid: 0000-0002-7797-5290 surname: Verkissen fullname: Verkissen, Mariëtte N. – sequence: 34 givenname: Andrew orcidid: 0000-0002-3214-1188 surname: Wilcock fullname: Wilcock, Andrew – sequence: 35 givenname: Marieke orcidid: 0000-0003-2934-8740 surname: Zwakman fullname: Zwakman, Marieke – sequence: 36 givenname: Agnes surname: van der Heide fullname: van der Heide, Agnes – sequence: 37 givenname: Judith A. C. surname: Rietjens fullname: Rietjens, Judith A. C. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33186365$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1037/0022-3514.78.6.1150 10.1111/jgs.15333 10.1186/s12885-016-2298-x 10.1016/j.jpainsymman.2011.05.011 10.1016/j.jclinepi.2015.09.002 10.1093/jnci/85.5.365 10.1001/jamaoncol.2018.4014 10.1037/0022-3514.56.2.267 10.1001/archinte.162.14.1611 10.1177/0269216314526272 10.1016/j.jpainsymman.2018.04.009 10.1177/0269216315616759 10.1016/j.ejca.2005.04.041 10.1038/s41416-018-0303-7 10.1136/thoraxjnl-2016-209806 10.1136/bmj.c1345 10.1007/s00520-019-04956-1 10.1002/sim.6181 10.1089/jpm.2017.0459 10.1016/j.jval.2018.07.002 10.1177/0269216318809582 10.1017/S1478951510000490 10.1200/JCO.2011.40.8872 10.1001/jamainternmed.2019.0077 10.1093/biostatistics/kxx045 10.1001/jama.300.14.1665 10.1016/j.jamda.2014.01.008 10.1207/s15327558ijbm0401_6 10.1016/j.pec.2009.10.004 10.1016/j.jpainsymman.2017.08.025 10.1186/s12910-019-0353-2 10.1016/S1470-2045(17)30582-X 10.1016/j.ejca.2018.11.023 10.1002/sim.3177 10.1016/j.jpainsymman.2018.05.016 10.1177/0269216318757623 10.1177/0269216318784474 10.1016/j.jpainsymman.2019.01.016 10.1016/j.ejca.2005.06.022 |
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| References | G Liegl (pmed.1003422.ref021) 2019; 107 NK Aaronson (pmed.1003422.ref019) 1993; 85 C-P Lin (pmed.1003422.ref010) 2019; 33 AM Wood (pmed.1003422.ref031) 2008; 27 RA Stein (pmed.1003422.ref013) 2013; 31 LJ Jabbarian (pmed.1003422.ref028) 2019; 22 A Bredart (pmed.1003422.ref026) 2005; 41 pmed.1003422.ref042 MA Petersen (pmed.1003422.ref020) 2016; 70 M Groenvold (pmed.1003422.ref022) 2006; 42 JAC Rietjens (pmed.1003422.ref006) 2017; 18 CH Houben (pmed.1003422.ref008) 2014; 15 A Overbeek (pmed.1003422.ref039) 2018; 66 A Brinkman-Stoppelenburg (pmed.1003422.ref007) 2014; 28 RJA Little (pmed.1003422.ref029) 2014 LJ Jabbarian (pmed.1003422.ref044) 2019; 57 JAC Rietjens (pmed.1003422.ref017) 2016; 16 RL Sudore (pmed.1003422.ref041) 2018; 55 C Borreani (pmed.1003422.ref002) 2012; 43 CE Schwartz (pmed.1003422.ref038) 2002; 162 G Jimenez (pmed.1003422.ref009) 2018; 56 SB Johnson (pmed.1003422.ref012) 2018; 119 CS Carver (pmed.1003422.ref024) 1989; 56 NK Arora (pmed.1003422.ref027) 2009; 77 JJ Sanders (pmed.1003422.ref040) 2018; 21 TE Raghunathan (pmed.1003422.ref030) 2001; 27 CS Carver (pmed.1003422.ref023) 1997; 4 L Wen (pmed.1003422.ref037) 2018; 19 R Bernacki (pmed.1003422.ref016) 2019; 179 A Donner (pmed.1003422.ref033) 2010 M Zwakman (pmed.1003422.ref005) 2018; 32 AA Wright (pmed.1003422.ref001) 2008; 300 LJ Jabbarian (pmed.1003422.ref004) 2018; 73 M Zwakman (pmed.1003422.ref032) 2020; 28 MC Kars (pmed.1003422.ref034) 2016; 30 MA Stewart (pmed.1003422.ref003) 1995; 152 L Jones (pmed.1003422.ref011) 2011; 9 SM Fischer (pmed.1003422.ref014) 2018; 4 KM Detering (pmed.1003422.ref018) 2010; 340 EJ Tchetgen Tchetgen (pmed.1003422.ref036) 2014; 33 AL Stanton (pmed.1003422.ref025) 2000; 78 M Di Paolo (pmed.1003422.ref043) 2019; 20 L Dunleavy (pmed.1003422.ref035) 2018; 32 AS Epstein (pmed.1003422.ref015) 2018; 56 |
| References_xml | – volume: 78 start-page: 1150 issue: 6 year: 2000 ident: pmed.1003422.ref025 article-title: Coping through emotional approach: scale construction and validation publication-title: J Pers Soc Psychol doi: 10.1037/0022-3514.78.6.1150 – volume: 66 start-page: 1089 issue: 6 year: 2018 ident: pmed.1003422.ref039 article-title: Advance care planning in frail older adults: a cluster randomized controlled trial publication-title: J Am Geriatr Soc doi: 10.1111/jgs.15333 – volume: 16 start-page: 264 issue: 1 year: 2016 ident: pmed.1003422.ref017 article-title: Advance care planning—a multi-centre cluster randomised clinical trial: the research protocol of the ACTION study publication-title: BMC Cancer doi: 10.1186/s12885-016-2298-x – volume: 43 start-page: 739 issue: 4 year: 2012 ident: pmed.1003422.ref002 article-title: Talking about end-of-life preferences with advanced cancer patients: factors influencing feasibility publication-title: J Pain Symptom Manage doi: 10.1016/j.jpainsymman.2011.05.011 – volume: 70 start-page: 90 year: 2016 ident: pmed.1003422.ref020 article-title: An emotional functioning item bank of 24 items for computerized adaptive testing (CAT) was established publication-title: J Clin Epidemiol doi: 10.1016/j.jclinepi.2015.09.002 – volume: 85 start-page: 365 issue: 5 year: 1993 ident: pmed.1003422.ref019 article-title: The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology publication-title: J Natl Cancer Inst doi: 10.1093/jnci/85.5.365 – volume: 4 start-page: 1736 issue: 12 year: 2018 ident: pmed.1003422.ref014 article-title: Effect of Apoyo con Cariño (Support with Caring) trial of a patient navigator intervention to improve palliative care outcomes for Latino adults with advanced cancer: a randomized clinical trial publication-title: JAMA Oncol doi: 10.1001/jamaoncol.2018.4014 – volume: 56 start-page: 267 issue: 2 year: 1989 ident: pmed.1003422.ref024 article-title: Assessing coping strategies: a theoretically based approach publication-title: J Pers Soc Psychol doi: 10.1037/0022-3514.56.2.267 – volume: 162 start-page: 1611 issue: 14 year: 2002 ident: pmed.1003422.ref038 article-title: Early intervention in planning end-of-life care with ambulatory geriatric patients: results of a pilot trial publication-title: Arch Intern Med doi: 10.1001/archinte.162.14.1611 – volume: 28 start-page: 1000 issue: 8 year: 2014 ident: pmed.1003422.ref007 article-title: The effects of advance care planning on end-of-life care: a systematic review publication-title: Palliat Med doi: 10.1177/0269216314526272 – volume: 56 start-page: 169 issue: 2 year: 2018 ident: pmed.1003422.ref015 article-title: A randomized trial of acceptability and effects of values-based advance care planning in outpatient oncology: person-centered oncologic care and choices publication-title: J Pain Symptom Manage doi: 10.1016/j.jpainsymman.2018.04.009 – volume: 30 start-page: 533 issue: 6 year: 2016 ident: pmed.1003422.ref034 article-title: A systematic review of reasons for gatekeeping in palliative care research publication-title: Palliat Med doi: 10.1177/0269216315616759 – volume: 41 start-page: 2120 issue: 14 year: 2005 ident: pmed.1003422.ref026 article-title: An international prospective study of the EORTC cancer in-patient satisfaction with care measure (EORTC IN-PATSAT32) publication-title: Eur J Cancer doi: 10.1016/j.ejca.2005.04.041 – volume: 119 start-page: 1182 issue: 10 year: 2018 ident: pmed.1003422.ref012 article-title: A randomised controlled trial of an advance care planning intervention for patients with incurable cancer publication-title: Br J Cancer doi: 10.1038/s41416-018-0303-7 – volume: 27 start-page: 85 issue: 1 year: 2001 ident: pmed.1003422.ref030 article-title: A multivariate technique for multiply imputing missing values using a sequence of regression models publication-title: Survey Methodol – volume: 73 start-page: 222 issue: 3 year: 2018 ident: pmed.1003422.ref004 article-title: Advance care planning for patients with chronic respiratory diseases: a systematic review of preferences and practices publication-title: Thorax doi: 10.1136/thoraxjnl-2016-209806 – volume: 340 start-page: c1345 year: 2010 ident: pmed.1003422.ref018 article-title: The impact of advance care planning on end of life care in elderly patients: randomised controlled trial publication-title: BMJ doi: 10.1136/bmj.c1345 – volume-title: Statistical analysis with missing data year: 2014 ident: pmed.1003422.ref029 – volume: 28 start-page: 1513 issue: 3 year: 2020 ident: pmed.1003422.ref032 article-title: Content analysis of advance directives completed by patients with advanced cancer as part of an advance care planning intervention: insights gained from the ACTION trial publication-title: Support Care Cancer doi: 10.1007/s00520-019-04956-1 – volume: 33 start-page: 3601 issue: 21 year: 2014 ident: pmed.1003422.ref036 article-title: Identification and estimation of survivor average causal effects publication-title: Stat Med doi: 10.1002/sim.6181 – volume: 21 start-page: S17 issue: S2 year: 2018 ident: pmed.1003422.ref040 article-title: Achieving goal-concordant care: a conceptual model and approach to measuring serious illness communication and its impact publication-title: J Palliat Med doi: 10.1089/jpm.2017.0459 – volume: 22 start-page: 92 issue: 1 year: 2019 ident: pmed.1003422.ref028 article-title: Assessing emotional functioning with increased power: relative validity of a customized EORTC short form in the international ACTION trial publication-title: Value Health doi: 10.1016/j.jval.2018.07.002 – volume: 33 start-page: 5 issue: 1 year: 2019 ident: pmed.1003422.ref010 article-title: The conceptual models and mechanisms of action that underpin advance care planning for cancer patients: a systematic review of randomised controlled trials publication-title: Palliat Med doi: 10.1177/0269216318809582 – volume: 9 start-page: 3 issue: 1 year: 2011 ident: pmed.1003422.ref011 article-title: Advance care planning in advanced cancer: can it be achieved? An exploratory randomized patient preference trial of a care planning discussion publication-title: Palliat Support Care doi: 10.1017/S1478951510000490 – volume: 31 start-page: 3403 issue: 27 year: 2013 ident: pmed.1003422.ref013 article-title: Randomized controlled trial of a structured intervention to facilitate end-of-life decision making in patients with advanced cancer publication-title: J Clin Oncol doi: 10.1200/JCO.2011.40.8872 – volume: 152 start-page: 1423 issue: 9 year: 1995 ident: pmed.1003422.ref003 article-title: Effective physician-patient communication and health outcomes: a review publication-title: CMAJ – volume: 179 start-page: 751 issue: 6 year: 2019 ident: pmed.1003422.ref016 article-title: Effect of the Serious Illness Care Program in outpatient oncology: a cluster randomized clinical trial publication-title: JAMA Intern Med doi: 10.1001/jamainternmed.2019.0077 – volume: 19 start-page: 407 issue: 4 year: 2018 ident: pmed.1003422.ref037 article-title: Methods for handling longitudinal outcome processes truncated by dropout and death publication-title: Biostatistics doi: 10.1093/biostatistics/kxx045 – volume: 300 start-page: 1665 issue: 14 year: 2008 ident: pmed.1003422.ref001 article-title: Associations between end-of-life discussions, patient mental health, medical care near death, and caregiver bereavement adjustment publication-title: JAMA doi: 10.1001/jama.300.14.1665 – volume: 15 start-page: 477 issue: 7 year: 2014 ident: pmed.1003422.ref008 article-title: Efficacy of advance care planning: a systematic review and meta-analysis publication-title: J Am Med Dir Assoc doi: 10.1016/j.jamda.2014.01.008 – volume: 4 start-page: 92 issue: 1 year: 1997 ident: pmed.1003422.ref023 article-title: You want to measure coping but your protocol’s too long: consider the brief cope publication-title: Int J Behav Med doi: 10.1207/s15327558ijbm0401_6 – volume: 77 start-page: 404 issue: 3 year: 2009 ident: pmed.1003422.ref027 article-title: Physicians’ decision-making style and psychosocial outcomes among cancer survivors publication-title: Patient Educ Couns doi: 10.1016/j.pec.2009.10.004 – volume: 55 start-page: 245 issue: 2 year: 2018 ident: pmed.1003422.ref041 article-title: Outcomes that define successful advance care planning: a Delphi panel consensus publication-title: J Pain Symptom Manage doi: 10.1016/j.jpainsymman.2017.08.025 – volume: 20 start-page: 17 issue: 1 year: 2019 ident: pmed.1003422.ref043 article-title: A review and analysis of new Italian law 219/2017: ‘provisions for informed consent and advance directives treatment’ publication-title: BMC Med Ethics doi: 10.1186/s12910-019-0353-2 – volume: 18 start-page: e543 issue: 9 year: 2017 ident: pmed.1003422.ref006 article-title: Definition and recommendations for advance care planning: an international consensus supported by the European Association for Palliative Care publication-title: Lancet Oncol doi: 10.1016/S1470-2045(17)30582-X – volume: 107 start-page: 133 year: 2019 ident: pmed.1003422.ref021 article-title: Establishing the European Norm for the health-related quality of life domains of the computer-adaptive test EORTC CAT Core publication-title: Eur J Cancer doi: 10.1016/j.ejca.2018.11.023 – volume-title: Design and analysis of cluster randomization trials in health research year: 2010 ident: pmed.1003422.ref033 – volume: 27 start-page: 3227 issue: 17 year: 2008 ident: pmed.1003422.ref031 article-title: How should variable selection be performed with multiply imputed data? publication-title: Stat Med doi: 10.1002/sim.3177 – volume: 56 start-page: 436 issue: 3 year: 2018 ident: pmed.1003422.ref009 article-title: Overview of systematic reviews of advance care planning: summary of evidence and global lessons publication-title: J Pain Symptom Manage doi: 10.1016/j.jpainsymman.2018.05.016 – volume: 32 start-page: 990 issue: 5 year: 2018 ident: pmed.1003422.ref035 article-title: Using the ‘Social Marketing Mix Framework’ to explore recruitment barriers and facilitators in palliative care randomised controlled trials? A narrative synthesis review publication-title: Palliat Med doi: 10.1177/0269216318757623 – ident: pmed.1003422.ref042 – volume: 32 start-page: 1305 issue: 8 year: 2018 ident: pmed.1003422.ref005 article-title: Advance care planning: a systematic review about experiences of patients with a life-threatening or life-limiting illness publication-title: Palliat Med doi: 10.1177/0269216318784474 – volume: 57 start-page: 1071 issue: 6 year: 2019 ident: pmed.1003422.ref044 article-title: The stability of treatment preferences among patients with advanced cancer publication-title: J Pain Symptom Manage doi: 10.1016/j.jpainsymman.2019.01.016 – volume: 42 start-page: 55 issue: 1 year: 2006 ident: pmed.1003422.ref022 article-title: The development of the EORTC QLQ-C15-PAL: a shortened questionnaire for cancer patients in palliative care publication-title: Eur J Cancer doi: 10.1016/j.ejca.2005.06.022 |
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| Title | Advance care planning in patients with advanced cancer: A 6-country, cluster-randomised clinical trial |
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