The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation

RECQL4 mutations are associated with Rothmund Thomson Syndrome (RTS), RAPADILINO Syndrome and Baller-Gerold Syndrome. These patients display a range of benign skeletal abnormalities such as low bone mass. In addition, RTS patients have a highly increased incidence of osteosarcoma (OS). The role of R...

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Veröffentlicht in:	PLoS genetics Jg. 11; H. 4; S. e1005160
Hauptverfasser:	Ng, Alvin J. M., Walia, Mannu K., Smeets, Monique F., Mutsaers, Anthony J., Sims, Natalie A., Purton, Louise E., Walsh, Nicole C., Martin, T. John, Walkley, Carl R.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 01.04.2015 Public Library of Science (PLoS)
Schlagworte:	Animals Bone Neoplasms - genetics Bone Neoplasms - metabolism Bones Cell cycle Cell Proliferation Deoxyribonucleic acid DNA DNA sequencing Expansion Gene Deletion Gene expression Genetic aspects Grants Methods Mice Mice, Inbred C57BL Mutation Osteoblasts - metabolism Osteogenesis Osteosarcoma Osteosarcoma - genetics Osteosarcoma - metabolism RecQ Helicases - genetics RecQ Helicases - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
ISSN:	1553-7404, 1553-7390, 1553-7404
Online-Zugang:	Volltext
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