A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers

Mammalian genomes are pervasively transcribed outside mapped protein-coding genes. One class of extragenic transcription products is represented by long non-coding RNAs (lncRNAs), some of which result from Pol_II transcription of bona-fide RNA genes. Whether all lncRNAs described insofar are product...

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Bibliographic Details
Published in:	PLoS biology Vol. 8; no. 5; p. e1000384
Main Authors:	De Santa, Francesca, Barozzi, Iros, Mietton, Flore, Ghisletti, Serena, Polletti, Sara, Tusi, Betsabeh Khoramian, Muller, Heiko, Ragoussis, Jiannis, Wei, Chia-Lin, Natoli, Gioacchino
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.05.2010 Public Library of Science (PLoS)
Subjects:	Animals Binding Sites Binding sites (Biochemistry) Cell Biology/Gene Expression Cell Biology/Leukocyte Signaling and Gene Expression Experiments Female Fractions Gene Expression Regulation Genetic transcription Genetics Genetics and Genomics/Epigenetics Genomes Genomics Humans Immunology/Innate Immunity Lipopolysaccharides - immunology Macrophage Activation - immunology Mice Molecular Biology/Histone Modification Noise Physiological aspects Promoter Regions, Genetic - genetics Proteins Regulatory Sequences, Nucleic Acid RNA polymerase RNA Polymerase II - genetics RNA Polymerase II - metabolism RNA polymerases RNA, Untranslated - genetics Signatures Transcription, Genetic Italy United Kingdom Singapore Promoter Regions, Genetic Humans RNA, Untranslated Regulatory Sequences, Nucleic Acid Gene Expression Regulation Lipopolysaccharides Macrophage Activation Animals Female Transcription, Genetic Mice Binding Sites RNA Polymerase II
ISSN:	1545-7885, 1544-9173, 1545-7885
Online Access:	Get full text
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