Pharmacokinetics, optimal dosing, and safety of linezolid in children with multidrug-resistant tuberculosis: Combined data from two prospective observational studies

Linezolid is increasingly important for multidrug-resistant tuberculosis (MDR-TB) treatment. However, among children with MDR-TB, there are no linezolid pharmacokinetic data, and its adverse effects have not yet been prospectively described. We characterised the pharmacokinetics, safety, and optimal...

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Bibliographic Details
Published in:	PLoS medicine Vol. 16; no. 4; p. e1002789
Main Authors:	Garcia-Prats, Anthony J., Schaaf, H. Simon, Draper, Heather R., Garcia-Cremades, Maria, Winckler, Jana, Wiesner, Lubbe, Hesseling, Anneke C., Savic, Rada M.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 30.04.2019 Public Library of Science (PLoS)
Subjects:	Adolescent Adults Adverse drug reactions Analysis Anemia Antimicrobial agents Antitubercular Agents - administration & dosage Antitubercular Agents - adverse effects Antitubercular Agents - pharmacokinetics Bedaquiline Bioengineering Chemotherapy Child Child health Child, Preschool Children Children & youth Childrens health Complications and side effects Computer simulation Dosage Dosage and administration Dose-Response Relationship, Drug Drug dosages Drug Monitoring Drug resistance Drug therapy Exposure Female Funding Health sciences HIV Human immunodeficiency virus Humans Infant Infectious diseases Linezolid Linezolid - administration & dosage Linezolid - adverse effects Linezolid - pharmacokinetics Male Medicine Microbial drug resistance Multidrug resistance Multidrug resistant organisms Observational studies Patients Pediatrics Peripheral neuropathy Pharmacokinetics Population-based studies Prospective Studies Risk factors Safety Safety and security measures Safety regulations Scaling Side effects South Africa Supervision Systematic review Treatment Outcome Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - metabolism Tutu, Desmond South Africa San Francisco California California United States > US
ISSN:	1549-1676, 1549-1277, 1549-1676
Online Access:	Get full text
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