In Vivo, Non-Invasive Characterization of Human Bone by Hybrid Broadband (600-1200 nm) Diffuse Optical and Correlation Spectroscopies

Non-invasive in vivo diffuse optical characterization of human bone opens a new possibility of diagnosing bone related pathologies. We present an in vivo characterization performed on seventeen healthy subjects at six different superficial bone locations: radius distal, radius proximal, ulna distal,...

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Vydáno v:	PLOS ONE Ročník 11; číslo 12; s. e0168426
Hlavní autoři:	Konugolu Venkata Sekar, Sanathana, Pagliazzi, Marco, Negredo, Eugènia, Martelli, Fabrizio, Farina, Andrea, Dalla Mora, Alberto, Lindner, Claus, Farzam, Parisa, Pérez-Álvarez, Núria, Puig, Jordi, Taroni, Paola, Pifferi, Antonio, Durduran, Turgut
Médium:	Journal Article Publikace
Jazyk:	angličtina
Vydáno:	United States Public Library of Science (PLoS) 20.12.2016 Public Library of Science
Témata:	90 Operations research, mathematical programming 90 Operations research, mathematical programming [Classificació AMS] Adult Biology and Life Sciences Blood Blood flow bone Bone blood flow Bone density Bones Broadband Calcaneus Classificació AMS Classificació AMS::90 Operations research Classificació AMS::90 Operations research, mathematical programming Collagen Contrast agents Correlation Diagnostic imaging diffuse spectroscopy diffuse-correlation spectroscopy Female Human Bone, Diffuse Correlation Spectroscopy Humans Innovations Investigació operativa Lipids Male Matemàtiques i estadística Matemàtiques i estadística::Investigació operativa [Àrees temàtiques de la UPC] mathematical programming Medical imaging Medicine Medicine and Health Sciences Metabolism Microvasculature Middle Aged NMR Nuclear magnetic resonance Observations Optical properties Osteoporosis Oxygen Oxygen Consumption Oxygen consumption (Metabolism) Oxygen metabolism Patient care Penetration depth Perfusion Physical Sciences Physiology Point-of-Care Systems Q R Radius Radius - diagnostic imaging Radius - metabolism Research and Analysis Methods Research Article Science Spectrophotometry Spectrophotometry - instrumentation Spectrophotometry - methods Spectroscopy Spectrum analysis Technology application TIME-RESOLVED REFLECTANCE; PENETRATION DEPTH; BLOOD-FLOW; HUMAN HEAD; TISSUE; DENSITY; LIGHT; OSTEOPOROSIS; TOMOGRAPHY; ABSORPTION Tissues Tomography, Optical Coherence Tomography, Optical Coherence - instrumentation Tomography, Optical Coherence - methods Trochanter Ulna Ulna - diagnostic imaging Ulna - metabolism Àrees temàtiques de la UPC Àrees temàtiques de la UPC::Matemàtiques i estadística::Investigació operativa Italy Spain
ISSN:	1932-6203, 1932-6203
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Popis
Shrnutí:	Non-invasive in vivo diffuse optical characterization of human bone opens a new possibility of diagnosing bone related pathologies. We present an in vivo characterization performed on seventeen healthy subjects at six different superficial bone locations: radius distal, radius proximal, ulna distal, ulna proximal, trochanter and calcaneus. A tailored diffuse optical protocol for high penetration depth combined with the rather superficial nature of considered tissues ensured the effective probing of the bone tissue. Measurements were performed using a broadband system for Time-Resolved Diffuse Optical Spectroscopy (TRS) to assess mean absorption and reduced scattering spectra in the 600-1200 nm range and Diffuse Correlation Spectroscopy (DCS) to monitor microvascular blood flow. Significant variations among tissue constituents were found between different locations; with radius distal rich of collagen, suggesting it as a prominent location for bone related measurements, and calcaneus bone having highest blood flow among the body locations being considered. By using TRS and DCS together, we are able to probe the perfusion and oxygen consumption of the tissue without any contrast agents. Therefore, we predict that these methods will be able to evaluate the impairment of the oxygen metabolism of the bone at the point-of-care.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceptualization: EN TD AP PT SKVS MP CL PF.Formal analysis: SKVS MP CL.Funding acquisition: AP TD.Investigation: MP CL.Methodology: EN.Resources: MP CL FM PT AF ADM NP JP EN.Software: AF FM.Supervision: AP TD.Validation: SKVS.Visualization: SKVS.Writing – original draft: SKVS.Writing – review & editing: SKVS MP PT AP TD. Competing Interests: ICFO has equity ownership in the spin-off company HemoPhotonics S.L. HemoPhotonics did not play any role on the decision on publication, data interpretation and analysis. Potential financial conflicts of interest and objectivity of research have been monitored by ICFO’s Knowledge & Technology Transfer Department. No financial conflicts of interest were identified. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0168426