In Vivo, Non-Invasive Characterization of Human Bone by Hybrid Broadband (600-1200 nm) Diffuse Optical and Correlation Spectroscopies
Non-invasive in vivo diffuse optical characterization of human bone opens a new possibility of diagnosing bone related pathologies. We present an in vivo characterization performed on seventeen healthy subjects at six different superficial bone locations: radius distal, radius proximal, ulna distal,...
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| Veröffentlicht in: | PLOS ONE Jg. 11; H. 12; S. e0168426 |
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| Sprache: | Englisch |
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Public Library of Science (PLoS)
20.12.2016
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| ISSN: | 1932-6203, 1932-6203 |
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| Abstract | Non-invasive in vivo diffuse optical characterization of human bone opens a new possibility of diagnosing bone related pathologies. We present an in vivo characterization performed on seventeen healthy subjects at six different superficial bone locations: radius distal, radius proximal, ulna distal, ulna proximal, trochanter and calcaneus. A tailored diffuse optical protocol for high penetration depth combined with the rather superficial nature of considered tissues ensured the effective probing of the bone tissue. Measurements were performed using a broadband system for Time-Resolved Diffuse Optical Spectroscopy (TRS) to assess mean absorption and reduced scattering spectra in the 600-1200 nm range and Diffuse Correlation Spectroscopy (DCS) to monitor microvascular blood flow. Significant variations among tissue constituents were found between different locations; with radius distal rich of collagen, suggesting it as a prominent location for bone related measurements, and calcaneus bone having highest blood flow among the body locations being considered. By using TRS and DCS together, we are able to probe the perfusion and oxygen consumption of the tissue without any contrast agents. Therefore, we predict that these methods will be able to evaluate the impairment of the oxygen metabolism of the bone at the point-of-care. |
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| AbstractList | Non-invasive in vivo diffuse optical characterization of human bone opens a new possibility of diagnosing bone related pathologies. We present an in vivo characterization performed on seventeen healthy subjects at six different superficial bone locations: radius distal, radius proximal, ulna distal, ulna proximal, trochanter and calcaneus. A tailored diffuse optical protocol for high penetration depth combined with the rather superficial nature of considered tissues ensured the effective probing of the bone tissue. Measurements were performed using a broadband system for Time-Resolved Diffuse Optical Spectroscopy (TRS) to assess mean absorption and reduced scattering spectra in the 600–1200 nm range and Diffuse Correlation Spectroscopy (DCS) to monitor microvascular blood flow. Significant variations among tissue constituents were found between different locations; with radius distal rich of collagen, suggesting it as a prominent location for bone related measurements, and calcaneus bone having highest blood flow among the body locations being considered. By using TRS and DCS together, we are able to probe the perfusion and oxygen consumption of the tissue without any contrast agents. Therefore, we predict that these methods will be able to evaluate the impairment of the oxygen metabolism of the bone at the point-of-care.
Peer Reviewed Non-invasive in vivo diffuse optical characterization of human bone opens a new possibility of diagnosing bone related pathologies. We present an in vivo characterization performed on seventeen healthy subjects at six different superficial bone locations: radius distal, radius proximal, ulna distal, ulna proximal, trochanter and calcaneus. A tailored diffuse optical protocol for high penetration depth combined with the rather superficial nature of considered tissues ensured the effective probing of the bone tissue. Measurements were performed using a broadband system for Time-Resolved Diffuse Optical Spectroscopy (TRS) to assess mean absorption and reduced scattering spectra in the 600-1200 nm range and Diffuse Correlation Spectroscopy (DCS) to monitor microvascular blood flow. Significant variations among tissue constituents were found between different locations; with radius distal rich of collagen, suggesting it as a prominent location for bone related measurements, and calcaneus bone having highest blood flow among the body locations being considered. By using TRS and DCS together, we are able to probe the perfusion and oxygen consumption of the tissue without any contrast agents. Therefore, we predict that these methods will be able to evaluate the impairment of the oxygen metabolism of the bone at the point-of-care. Non-invasive in vivo diffuse optical characterization of human bone opens a new possibility of diagnosing bone related pathologies. We present an in vivo characterization performed on seventeen healthy subjects at six different superficial bone locations: radius distal, radius proximal, ulna distal, ulna proximal, trochanter and calcaneus. A tailored diffuse optical protocol for high penetration depth combined with the rather superficial nature of considered tissues ensured the effective probing of the bone tissue. Measurements were performed using a broadband system for Time-Resolved Diffuse Optical Spectroscopy (TRS) to assess mean absorption and reduced scattering spectra in the 600-1200 nm range and Diffuse Correlation Spectroscopy (DCS) to monitor microvascular blood flow. Significant variations among tissue constituents were found between different locations; with radius distal rich of collagen, suggesting it as a prominent location for bone related measurements, and calcaneus bone having highest blood flow among the body locations being considered. By using TRS and DCS together, we are able to probe the perfusion and oxygen consumption of the tissue without any contrast agents. Therefore, we predict that these methods will be able to evaluate the impairment of the oxygen metabolism of the bone at the point-of-care.Non-invasive in vivo diffuse optical characterization of human bone opens a new possibility of diagnosing bone related pathologies. We present an in vivo characterization performed on seventeen healthy subjects at six different superficial bone locations: radius distal, radius proximal, ulna distal, ulna proximal, trochanter and calcaneus. A tailored diffuse optical protocol for high penetration depth combined with the rather superficial nature of considered tissues ensured the effective probing of the bone tissue. Measurements were performed using a broadband system for Time-Resolved Diffuse Optical Spectroscopy (TRS) to assess mean absorption and reduced scattering spectra in the 600-1200 nm range and Diffuse Correlation Spectroscopy (DCS) to monitor microvascular blood flow. Significant variations among tissue constituents were found between different locations; with radius distal rich of collagen, suggesting it as a prominent location for bone related measurements, and calcaneus bone having highest blood flow among the body locations being considered. By using TRS and DCS together, we are able to probe the perfusion and oxygen consumption of the tissue without any contrast agents. Therefore, we predict that these methods will be able to evaluate the impairment of the oxygen metabolism of the bone at the point-of-care. |
| Audience | Academic |
| Author | Jordi Puig Eugenia Negredo Claus Lindner Antonio Pifferi Marco Pagliazzi Turgut Durduran Paola Taroni Sanathana Konugolu Venkata Sekar Andrea Farina Núria Pérez-Álvarez Parisa Farzam Alberto Dalla Mora Fabrizio Martelli |
| AuthorAffiliation | 6 Consiglio Nazionale delle Ricerche - Istituto di Fotonica e Nanotecnologie, Milano, Italy 3 Lluita contra la Sida Foundation, Germans Trias i Pujol University Hospital, Badalona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain 4 Universitat de Vic-Universitat Central de Catalunya, Vic, Barcelona, Spain 5 Dipartimento di Fisica e Astronomia, Università degli Studi di Firenze, Sesto Fiorentino, Firenze, Italy 1 Dipartimento di Fisica, Politecnico di Milano, Milano, Italy 7 Statistics and Operations Research Department, Universitat Politècnica de Catalunya, Barcelona, Spain 2 ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels, Barcelona, Spain 8 Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain Medical Photonics Research Center, Hamamatsu University School of Medicine, JAPAN |
| AuthorAffiliation_xml | – name: 2 ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels, Barcelona, Spain – name: 8 Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain – name: 1 Dipartimento di Fisica, Politecnico di Milano, Milano, Italy – name: 5 Dipartimento di Fisica e Astronomia, Università degli Studi di Firenze, Sesto Fiorentino, Firenze, Italy – name: Medical Photonics Research Center, Hamamatsu University School of Medicine, JAPAN – name: 3 Lluita contra la Sida Foundation, Germans Trias i Pujol University Hospital, Badalona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain – name: 7 Statistics and Operations Research Department, Universitat Politècnica de Catalunya, Barcelona, Spain – name: 6 Consiglio Nazionale delle Ricerche - Istituto di Fotonica e Nanotecnologie, Milano, Italy – name: 4 Universitat de Vic-Universitat Central de Catalunya, Vic, Barcelona, Spain |
| Author_xml | – sequence: 1 givenname: Sanathana orcidid: 0000-0003-0912-1282 surname: Konugolu Venkata Sekar fullname: Konugolu Venkata Sekar, Sanathana – sequence: 2 givenname: Marco surname: Pagliazzi fullname: Pagliazzi, Marco – sequence: 3 givenname: Eugènia surname: Negredo fullname: Negredo, Eugènia – sequence: 4 givenname: Fabrizio surname: Martelli fullname: Martelli, Fabrizio – sequence: 5 givenname: Andrea surname: Farina fullname: Farina, Andrea – sequence: 6 givenname: Alberto surname: Dalla Mora fullname: Dalla Mora, Alberto – sequence: 7 givenname: Claus surname: Lindner fullname: Lindner, Claus – sequence: 8 givenname: Parisa surname: Farzam fullname: Farzam, Parisa – sequence: 9 givenname: Núria surname: Pérez-Álvarez fullname: Pérez-Álvarez, Núria – sequence: 10 givenname: Jordi surname: Puig fullname: Puig, Jordi – sequence: 11 givenname: Paola surname: Taroni fullname: Taroni, Paola – sequence: 12 givenname: Antonio surname: Pifferi fullname: Pifferi, Antonio – sequence: 13 givenname: Turgut surname: Durduran fullname: Durduran, Turgut |
| BackLink | https://cir.nii.ac.jp/crid/1873961342369083904$$DView record in CiNii https://www.ncbi.nlm.nih.gov/pubmed/27997565$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1038_s41598_025_06138_y crossref_primary_10_3390_app11104616 crossref_primary_10_1002_jor_24035 crossref_primary_10_1016_j_bpc_2017_07_004 crossref_primary_10_1152_japplphysiol_00595_2020 crossref_primary_10_1088_1742_6596_2822_1_012019 crossref_primary_10_1002_jor_23622 crossref_primary_10_3389_fphys_2021_738239 crossref_primary_10_1109_JIOT_2025_3531542 crossref_primary_10_3390_app9245465 crossref_primary_10_1007_s40766_025_00067_2 crossref_primary_10_3389_fphys_2020_615977 crossref_primary_10_3389_fphot_2025_1559430 crossref_primary_10_3390_s17092115 |
| Cites_doi | 10.1117/1.JBO.18.7.076001 |
| ContentType | Journal Article Publication |
| Contributor | Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica |
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| Copyright | COPYRIGHT 2016 Public Library of Science 2016 Konugolu Venkata Sekar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Attribution-NonCommercial-NoDerivs 3.0 Spain info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/3.0/es 2016 Konugolu Venkata Sekar et al 2016 Konugolu Venkata Sekar et al |
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| DOI | 10.1371/journal.pone.0168426 |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceptualization: EN TD AP PT SKVS MP CL PF.Formal analysis: SKVS MP CL.Funding acquisition: AP TD.Investigation: MP CL.Methodology: EN.Resources: MP CL FM PT AF ADM NP JP EN.Software: AF FM.Supervision: AP TD.Validation: SKVS.Visualization: SKVS.Writing – original draft: SKVS.Writing – review & editing: SKVS MP PT AP TD. Competing Interests: ICFO has equity ownership in the spin-off company HemoPhotonics S.L. HemoPhotonics did not play any role on the decision on publication, data interpretation and analysis. Potential financial conflicts of interest and objectivity of research have been monitored by ICFO’s Knowledge & Technology Transfer Department. No financial conflicts of interest were identified. This does not alter our adherence to PLOS ONE policies on sharing data and materials. |
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| Snippet | Non-invasive in vivo diffuse optical characterization of human bone opens a new possibility of diagnosing bone related pathologies. We present an in vivo... |
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| SubjectTerms | 90 Operations research, mathematical programming 90 Operations research, mathematical programming [Classificació AMS] Adult Biology and Life Sciences Blood Blood flow bone Bone blood flow Bone density Bones Broadband Calcaneus Classificació AMS Classificació AMS::90 Operations research Classificació AMS::90 Operations research, mathematical programming Collagen Contrast agents Correlation Diagnostic imaging diffuse spectroscopy diffuse-correlation spectroscopy Female Human Bone, Diffuse Correlation Spectroscopy Humans Innovations Investigació operativa Lipids Male Matemàtiques i estadística Matemàtiques i estadística::Investigació operativa [Àrees temàtiques de la UPC] mathematical programming Medical imaging Medicine Medicine and Health Sciences Metabolism Microvasculature Middle Aged NMR Nuclear magnetic resonance Observations Optical properties Osteoporosis Oxygen Oxygen Consumption Oxygen consumption (Metabolism) Oxygen metabolism Patient care Penetration depth Perfusion Physical Sciences Physiology Point-of-Care Systems Q R Radius Radius - diagnostic imaging Radius - metabolism Research and Analysis Methods Research Article Science Spectrophotometry Spectrophotometry - instrumentation Spectrophotometry - methods Spectroscopy Spectrum analysis Technology application TIME-RESOLVED REFLECTANCE; PENETRATION DEPTH; BLOOD-FLOW; HUMAN HEAD; TISSUE; DENSITY; LIGHT; OSTEOPOROSIS; TOMOGRAPHY; ABSORPTION Tissues Tomography, Optical Coherence Tomography, Optical Coherence - instrumentation Tomography, Optical Coherence - methods Trochanter Ulna Ulna - diagnostic imaging Ulna - metabolism Àrees temàtiques de la UPC Àrees temàtiques de la UPC::Matemàtiques i estadística::Investigació operativa |
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| Title | In Vivo, Non-Invasive Characterization of Human Bone by Hybrid Broadband (600-1200 nm) Diffuse Optical and Correlation Spectroscopies |
| URI | https://cir.nii.ac.jp/crid/1873961342369083904 https://www.ncbi.nlm.nih.gov/pubmed/27997565 https://www.proquest.com/docview/1850758015 https://www.proquest.com/docview/1851304119 https://www.proquest.com/docview/1859485799 https://recercat.cat/handle/2072/285948 https://pubmed.ncbi.nlm.nih.gov/PMC5172608 https://doaj.org/article/b346d43abaa04b9e86d8b83b6f88623e http://dx.doi.org/10.1371/journal.pone.0168426 |
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