Genome-Wide Association Analysis of Incident Coronary Heart Disease (CHD) in African Americans: A Short Report

African Americans have the highest rate of mortality due to coronary heart disease (CHD). Although multiple loci have been identified influencing CHD risk in European-Americans using a genome-wide association (GWAS) approach, no GWAS of incident CHD has been reported for African Americans. We perfor...

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Vydané v:PLoS genetics Ročník 7; číslo 8; s. e1002199
Hlavní autori: Barbalic, Maja, Reiner, Alex P., Wu, Chunyuan, Hixson, James E., Franceschini, Nora, Eaton, Charles B., Heiss, Gerardo, Couper, David, Mosley, Thomas, Boerwinkle, Eric
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Public Library of Science 01.08.2011
Public Library of Science (PLoS)
Predmet:
African Americans
Aged
Biology
Black or African American - genetics
Cardiovascular disease
Coronary Disease - ethnology
Coronary Disease - genetics
Coronary heart disease
Female
Gene expression
Gene Expression Regulation
Genetic aspects
Genetic Loci - genetics
Genome-Wide Association Study
Genomes
Health aspects
Heart attacks
Humans
Kinases
Male
Medicine
Middle Aged
Mortality
Polymorphism, Single Nucleotide - genetics
Risk Factors
Womens health
United States
ISSN:1553-7404, 1553-7390, 1553-7404
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Shrnutí:African Americans have the highest rate of mortality due to coronary heart disease (CHD). Although multiple loci have been identified influencing CHD risk in European-Americans using a genome-wide association (GWAS) approach, no GWAS of incident CHD has been reported for African Americans. We performed a GWAS for incident CHD events collected during 19 years of follow-up in 2,905 African Americans from the Atherosclerosis Risk in Communities (ARIC) study. We identified a genome-wide significant SNP (rs1859023, MAF = 31%) located at 7q21 near the PFTK1 gene (HR = 0.57, 95% CI 0.46 to 0.69, p = 1.86×10(-08)), which replicated in an independent sample of over 8,000 African American women from the Women's Health Initiative (WHI) (HR = 0.81, 95% CI 0.70 to 0.93, p = 0.005). PFTK1 encodes a serine/threonine-protein kinase, PFTAIRE-1, that acts as a cyclin-dependent kinase regulating cell cycle progression and cell proliferation. This is the first finding of incident CHD locus identified by GWAS in African Americans.
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Conceived and designed the experiments: MB APR EB. Analyzed the data: MB APR CW. Contributed reagents/materials/analysis tools: APR JEH CBE GH DC TM EB. Wrote the paper: MB APR EB NF.
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1002199