Essential Role of Chromatin Remodeling Protein Bptf in Early Mouse Embryos and Embryonic Stem Cells

We have characterized the biological functions of the chromatin remodeling protein Bptf (Bromodomain PHD-finger Transcription Factor), the largest subunit of NURF (Nucleosome Remodeling Factor) in a mammal. Bptf mutants manifest growth defects at the post-implantation stage and are reabsorbed by E8....

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Bibliographic Details
Published in:	PLoS genetics Vol. 4; no. 10; p. e1000241
Main Authors:	Landry, Joseph, Sharov, Alexei A., Piao, Yulan, Sharova, Lioudmila V., Xiao, Hua, Southon, Eileen, Matta, Jennifer, Tessarollo, Lino, Zhang, Ying E., Ko, Minoru S. H., Kuehn, Michael R., Yamaguchi, Terry P., Wu, Carl
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.10.2008 Public Library of Science (PLoS)
Subjects:	Adenosine Triphosphatases - metabolism Animals Antigens, Nuclear - genetics Antigens, Nuclear - metabolism ATPases Associated with Diverse Cellular Activities Biochemistry/Transcription and Translation Cell Biology/Cell Growth and Division Cell Biology/Cell Signaling Cell Biology/Developmental Molecular Mechanisms Cell Biology/Gene Expression Cell Biology/Nuclear Structure and Function Cell Differentiation Chromatin Chromatin Assembly and Disassembly - physiology Chromosomal Proteins, Non-Histone - metabolism Developmental Biology/Cell Differentiation Developmental Biology/Developmental Molecular Mechanisms Developmental Biology/Embryology Developmental Biology/Molecular Development Developmental Biology/Morphogenesis and Cell Biology Developmental Biology/Pattern Formation Developmental Biology/Stem Cells DNA Helicases - metabolism DNA-Binding Proteins - metabolism Embryo, Mammalian - metabolism Embryonic Development Embryonic Stem Cells - cytology Embryonic Stem Cells - physiology Embryos Endoderm - embryology Genetics and Genomics/Animal Genetics Genetics and Genomics/Epigenetics Left-Right Determination Factors - metabolism Mice Mice, Knockout Mutation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Oligonucleotide Array Sequence Analysis Proteins Smad Proteins - metabolism Stem cells Transcription Factors - genetics Transcription Factors - metabolism
ISSN:	1553-7404, 1553-7390, 1553-7404
Online Access:	Get full text
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