Testosterone Trajectories and Reference Ranges in a Large Longitudinal Sample of Male Adolescents
Pubertal dynamics plays an important role in physical and psychological development of children and adolescents. We aim to provide reference ranges of plasma testosterone in a large longitudinal sample. Furthermore, we describe a measure of testosterone trajectories during adolescence that can be us...
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| Veröffentlicht in: | PloS one Jg. 9; H. 9; S. e108838 |
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30.09.2014
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| Abstract | Pubertal dynamics plays an important role in physical and psychological development of children and adolescents. We aim to provide reference ranges of plasma testosterone in a large longitudinal sample. Furthermore, we describe a measure of testosterone trajectories during adolescence that can be used in future investigations of development.
We carried out longitudinal measurements of plasma testosterone in 2,216 samples obtained from 513 males (9 to 17 years of age) from the Avon Longitudinal Study of Parents and Children. We used integration of a model fitted to each participant's testosterone trajectory to calculate a measure of average exposure to testosterone over adolescence. We pooled these data with corresponding values reported in the literature to provide a reference range of testosterone levels in males between the ages of 6 and 19 years.
The average values of total testosterone in the ALSPAC sample range from 0.82 nmol/L (Standard Deviation [SD]: 0.09) at 9 years of age to 16.5 (SD: 2.65) nmol/L at 17 years of age; these values are congruent with other reports in the literature. The average exposure to testosterone is associated with different features of testosterone trajectories such as Peak Testosterone Change, Age at Peak Testosterone Change, and Testosterone at 17 years of age as well as the timing of the growth spurt during puberty.
The average exposure to testosterone is a useful measure for future investigations using testosterone trajectories to examine pubertal dynamics. |
|---|---|
| AbstractList | Pubertal dynamics plays an important role in physical and psychological development of children and adolescents. We aim to provide reference ranges of plasma testosterone in a large longitudinal sample. Furthermore, we describe a measure of testosterone trajectories during adolescence that can be used in future investigations of development. We carried out longitudinal measurements of plasma testosterone in 2,216 samples obtained from 513 males (9 to 17 years of age) from the Avon Longitudinal Study of Parents and Children. We used integration of a model fitted to each participant's testosterone trajectory to calculate a measure of average exposure to testosterone over adolescence. We pooled these data with corresponding values reported in the literature to provide a reference range of testosterone levels in males between the ages of 6 and 19 years. The average values of total testosterone in the ALSPAC sample range from 0.82 nmol/L (Standard Deviation [SD]: 0.09) at 9 years of age to 16.5 (SD: 2.65) nmol/L at 17 years of age; these values are congruent with other reports in the literature. The average exposure to testosterone is associated with different features of testosterone trajectories such as Peak Testosterone Change, Age at Peak Testosterone Change, and Testosterone at 17 years of age as well as the timing of the growth spurt during puberty. The average exposure to testosterone is a useful measure for future investigations using testosterone trajectories to examine pubertal dynamics. PurposePubertal dynamics plays an important role in physical and psychological development of children and adolescents. We aim to provide reference ranges of plasma testosterone in a large longitudinal sample. Furthermore, we describe a measure of testosterone trajectories during adolescence that can be used in future investigations of development.MethodsWe carried out longitudinal measurements of plasma testosterone in 2,216 samples obtained from 513 males (9 to 17 years of age) from the Avon Longitudinal Study of Parents and Children. We used integration of a model fitted to each participant's testosterone trajectory to calculate a measure of average exposure to testosterone over adolescence. We pooled these data with corresponding values reported in the literature to provide a reference range of testosterone levels in males between the ages of 6 and 19 years.ResultsThe average values of total testosterone in the ALSPAC sample range from 0.82 nmol/L (Standard Deviation [SD]: 0.09) at 9 years of age to 16.5 (SD: 2.65) nmol/L at 17 years of age; these values are congruent with other reports in the literature. The average exposure to testosterone is associated with different features of testosterone trajectories such as Peak Testosterone Change, Age at Peak Testosterone Change, and Testosterone at 17 years of age as well as the timing of the growth spurt during puberty.ConclusionsThe average exposure to testosterone is a useful measure for future investigations using testosterone trajectories to examine pubertal dynamics. Pubertal dynamics plays an important role in physical and psychological development of children and adolescents. We aim to provide reference ranges of plasma testosterone in a large longitudinal sample. Furthermore, we describe a measure of testosterone trajectories during adolescence that can be used in future investigations of development.PURPOSEPubertal dynamics plays an important role in physical and psychological development of children and adolescents. We aim to provide reference ranges of plasma testosterone in a large longitudinal sample. Furthermore, we describe a measure of testosterone trajectories during adolescence that can be used in future investigations of development.We carried out longitudinal measurements of plasma testosterone in 2,216 samples obtained from 513 males (9 to 17 years of age) from the Avon Longitudinal Study of Parents and Children. We used integration of a model fitted to each participant's testosterone trajectory to calculate a measure of average exposure to testosterone over adolescence. We pooled these data with corresponding values reported in the literature to provide a reference range of testosterone levels in males between the ages of 6 and 19 years.METHODSWe carried out longitudinal measurements of plasma testosterone in 2,216 samples obtained from 513 males (9 to 17 years of age) from the Avon Longitudinal Study of Parents and Children. We used integration of a model fitted to each participant's testosterone trajectory to calculate a measure of average exposure to testosterone over adolescence. We pooled these data with corresponding values reported in the literature to provide a reference range of testosterone levels in males between the ages of 6 and 19 years.The average values of total testosterone in the ALSPAC sample range from 0.82 nmol/L (Standard Deviation [SD]: 0.09) at 9 years of age to 16.5 (SD: 2.65) nmol/L at 17 years of age; these values are congruent with other reports in the literature. The average exposure to testosterone is associated with different features of testosterone trajectories such as Peak Testosterone Change, Age at Peak Testosterone Change, and Testosterone at 17 years of age as well as the timing of the growth spurt during puberty.RESULTSThe average values of total testosterone in the ALSPAC sample range from 0.82 nmol/L (Standard Deviation [SD]: 0.09) at 9 years of age to 16.5 (SD: 2.65) nmol/L at 17 years of age; these values are congruent with other reports in the literature. The average exposure to testosterone is associated with different features of testosterone trajectories such as Peak Testosterone Change, Age at Peak Testosterone Change, and Testosterone at 17 years of age as well as the timing of the growth spurt during puberty.The average exposure to testosterone is a useful measure for future investigations using testosterone trajectories to examine pubertal dynamics.CONCLUSIONSThe average exposure to testosterone is a useful measure for future investigations using testosterone trajectories to examine pubertal dynamics. Purpose Pubertal dynamics plays an important role in physical and psychological development of children and adolescents. We aim to provide reference ranges of plasma testosterone in a large longitudinal sample. Furthermore, we describe a measure of testosterone trajectories during adolescence that can be used in future investigations of development. Methods We carried out longitudinal measurements of plasma testosterone in 2,216 samples obtained from 513 males (9 to 17 years of age) from the Avon Longitudinal Study of Parents and Children. We used integration of a model fitted to each participant's testosterone trajectory to calculate a measure of average exposure to testosterone over adolescence. We pooled these data with corresponding values reported in the literature to provide a reference range of testosterone levels in males between the ages of 6 and 19 years. Results The average values of total testosterone in the ALSPAC sample range from 0.82 nmol/L (Standard Deviation [SD]: 0.09) at 9 years of age to 16.5 (SD: 2.65) nmol/L at 17 years of age; these values are congruent with other reports in the literature. The average exposure to testosterone is associated with different features of testosterone trajectories such as Peak Testosterone Change, Age at Peak Testosterone Change, and Testosterone at 17 years of age as well as the timing of the growth spurt during puberty. Conclusions The average exposure to testosterone is a useful measure for future investigations using testosterone trajectories to examine pubertal dynamics. Purpose Pubertal dynamics plays an important role in physical and psychological development of children and adolescents. We aim to provide reference ranges of plasma testosterone in a large longitudinal sample. Furthermore, we describe a measure of testosterone trajectories during adolescence that can be used in future investigations of development. Methods We carried out longitudinal measurements of plasma testosterone in 2,216 samples obtained from 513 males (9 to 17 years of age) from the Avon Longitudinal Study of Parents and Children. We used integration of a model fitted to each participant’s testosterone trajectory to calculate a measure of average exposure to testosterone over adolescence. We pooled these data with corresponding values reported in the literature to provide a reference range of testosterone levels in males between the ages of 6 and 19 years. Results The average values of total testosterone in the ALSPAC sample range from 0.82 nmol/L (Standard Deviation [SD]: 0.09) at 9 years of age to 16.5 (SD: 2.65) nmol/L at 17 years of age; these values are congruent with other reports in the literature. The average exposure to testosterone is associated with different features of testosterone trajectories such as Peak Testosterone Change, Age at Peak Testosterone Change, and Testosterone at 17 years of age as well as the timing of the growth spurt during puberty. Conclusions The average exposure to testosterone is a useful measure for future investigations using testosterone trajectories to examine pubertal dynamics. Pubertal dynamics plays an important role in physical and psychological development of children and adolescents. We aim to provide reference ranges of plasma testosterone in a large longitudinal sample. Furthermore, we describe a measure of testosterone trajectories during adolescence that can be used in future investigations of development. We carried out longitudinal measurements of plasma testosterone in 2,216 samples obtained from 513 males (9 to 17 years of age) from the Avon Longitudinal Study of Parents and Children. We used integration of a model fitted to each participant's testosterone trajectory to calculate a measure of average exposure to testosterone over adolescence. We pooled these data with corresponding values reported in the literature to provide a reference range of testosterone levels in males between the ages of 6 and 19 years. The average values of total testosterone in the ALSPAC sample range from 0.82 nmol/L (Standard Deviation [SD]: 0.09) at 9 years of age to 16.5 (SD: 2.65) nmol/L at 17 years of age; these values are congruent with other reports in the literature. The average exposure to testosterone is associated with different features of testosterone trajectories such as Peak Testosterone Change, Age at Peak Testosterone Change, and Testosterone at 17 years of age as well as the timing of the growth spurt during puberty. The average exposure to testosterone is a useful measure for future investigations using testosterone trajectories to examine pubertal dynamics. |
| Audience | Academic |
| Author | Khairullah, Ammar May, Margaret T. Paus, Tomáš Cousino Klein, Laura Susman, Elizabeth J. Whetzel, Courtney A. Ingle, Suzanne M. |
| AuthorAffiliation | 3 School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom 1 Rotman Research Institute and Institute of Medical Science, University of Toronto, Toronto, Canada 4 Department of Biobehavioral Health and the Center for Healthy Aging, The Pennsylvania State University, State College, Pennsylvania, United States of America 2 Department of Biobehavioral Health and Penn State Institute of the Neurosciences, The Pennsylvania State University, State College, Pennsylvania, United States of America Brock University, Canada 5 Department of Biobehavioral Health, The Pennsylvania State University, State College, Pennsylvania, United States of America |
| AuthorAffiliation_xml | – name: Brock University, Canada – name: 4 Department of Biobehavioral Health and the Center for Healthy Aging, The Pennsylvania State University, State College, Pennsylvania, United States of America – name: 2 Department of Biobehavioral Health and Penn State Institute of the Neurosciences, The Pennsylvania State University, State College, Pennsylvania, United States of America – name: 1 Rotman Research Institute and Institute of Medical Science, University of Toronto, Toronto, Canada – name: 5 Department of Biobehavioral Health, The Pennsylvania State University, State College, Pennsylvania, United States of America – name: 3 School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom |
| Author_xml | – sequence: 1 givenname: Ammar surname: Khairullah fullname: Khairullah, Ammar – sequence: 2 givenname: Laura surname: Cousino Klein fullname: Cousino Klein, Laura – sequence: 3 givenname: Suzanne M. surname: Ingle fullname: Ingle, Suzanne M. – sequence: 4 givenname: Margaret T. surname: May fullname: May, Margaret T. – sequence: 5 givenname: Courtney A. surname: Whetzel fullname: Whetzel, Courtney A. – sequence: 6 givenname: Elizabeth J. surname: Susman fullname: Susman, Elizabeth J. – sequence: 7 givenname: Tomáš surname: Paus fullname: Paus, Tomáš |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25268961$$D View this record in MEDLINE/PubMed |
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| Copyright | COPYRIGHT 2014 Public Library of Science 2014 Khairullah et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2014 Khairullah et al 2014 Khairullah et al |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: TP EJS. Performed the experiments: LCK CAW. Analyzed the data: AK SMI MTM. Wrote the paper: AK TP. Competing Interests: The authors have declared that no competing interests exist. |
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10.1016/0022-4731(82)90038-3 – volume: 39 start-page: 163 year: 1993 ident: ref30 article-title: Circadian variation in serum free and non-SHBG-bound testosterone in normal men: measurements, and simulation using a mass action model publication-title: Clin Endocrinol doi: 10.1111/j.1365-2265.1993.tb01769.x – volume: 34 start-page: 332 year: 2009 ident: ref9 article-title: Sex steroids and brain structure in pubertal boys and girls publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2008.09.012 – ident: ref23 doi: 10.1186/1471-2288-5-13 – volume: 39 start-page: 664 year: 1974 ident: ref14 article-title: Serum gonadotropin, testosterone and prolactin concentrations throughout puberty in boys: a longitudinal study publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem-39-4-664 – volume: 28 start-page: 916 year: 2003 ident: ref21 article-title: Two formulas for computation of the area under the curve represent measures of total hormone concentration versus 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for psychosis: salivary testosterone in adolescent boys with prodromal symptoms publication-title: Psychol Med doi: 10.1017/S0033291710002576 – volume: 28 start-page: 83 year: 1988 ident: ref27 article-title: The mechanism of the adolescent growth spurt induced by low dose pulsatile GnRH treatment publication-title: Clin Endocrinol doi: 10.1111/j.1365-2265.1988.tb01207.x – ident: ref24 doi: 10.1002/9780470743386 – volume: 28 start-page: 9519 year: 2008 ident: ref10 article-title: Growth of white matter in the adolescent brain: role of testosterone and androgen receptor publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1212-08.2008 – volume: 29 start-page: 201 year: 2008 ident: ref15 article-title: Dihydrotestosterone and testosterone throughout the lifespan of Czech men publication-title: Neuro Endocrinol Lett – ident: ref17 doi: 10.1093/ije/dys064 |
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| SubjectTerms | Adolescent Adolescents Age Age Factors Androgens Bioavailability Biology and Life Sciences Child Child development Children Circadian Rhythm Correlation analysis Exposure Health care Humans Laboratories Longitudinal Studies Male Males Medicine and Health Sciences Mens health NMR Nuclear magnetic resonance Outdoor air quality Parents Parents & parenting Puberty Reference Values Sex Hormone-Binding Globulin - analysis Steroids Studies Teenagers Testosterone Testosterone - blood Testosterone - standards Trajectory measurement Values Young Adult Youth |
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| Title | Testosterone Trajectories and Reference Ranges in a Large Longitudinal Sample of Male Adolescents |
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