Testosterone Trajectories and Reference Ranges in a Large Longitudinal Sample of Male Adolescents

Pubertal dynamics plays an important role in physical and psychological development of children and adolescents. We aim to provide reference ranges of plasma testosterone in a large longitudinal sample. Furthermore, we describe a measure of testosterone trajectories during adolescence that can be us...

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Vydáno v:PloS one Ročník 9; číslo 9; s. e108838
Hlavní autoři: Khairullah, Ammar, Cousino Klein, Laura, Ingle, Suzanne M., May, Margaret T., Whetzel, Courtney A., Susman, Elizabeth J., Paus, Tomáš
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Public Library of Science 30.09.2014
Public Library of Science (PLoS)
Témata:
Adolescent
Adolescents
Age
Age Factors
Androgens
Bioavailability
Biology and Life Sciences
Child
Child development
Children
Circadian Rhythm
Correlation analysis
Exposure
Health care
Humans
Laboratories
Longitudinal Studies
Male
Males
Medicine and Health Sciences
Mens health
NMR
Nuclear magnetic resonance
Outdoor air quality
Parents
Parents & parenting
Puberty
Reference Values
Sex Hormone-Binding Globulin - analysis
Steroids
Studies
Teenagers
Testosterone
Testosterone - blood
Testosterone - standards
Trajectory measurement
Values
Young Adult
Youth
Canada
United Kingdom > UK
United States > US
Pennsylvania
ISSN:1932-6203, 1932-6203
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Shrnutí:Pubertal dynamics plays an important role in physical and psychological development of children and adolescents. We aim to provide reference ranges of plasma testosterone in a large longitudinal sample. Furthermore, we describe a measure of testosterone trajectories during adolescence that can be used in future investigations of development. We carried out longitudinal measurements of plasma testosterone in 2,216 samples obtained from 513 males (9 to 17 years of age) from the Avon Longitudinal Study of Parents and Children. We used integration of a model fitted to each participant's testosterone trajectory to calculate a measure of average exposure to testosterone over adolescence. We pooled these data with corresponding values reported in the literature to provide a reference range of testosterone levels in males between the ages of 6 and 19 years. The average values of total testosterone in the ALSPAC sample range from 0.82 nmol/L (Standard Deviation [SD]: 0.09) at 9 years of age to 16.5 (SD: 2.65) nmol/L at 17 years of age; these values are congruent with other reports in the literature. The average exposure to testosterone is associated with different features of testosterone trajectories such as Peak Testosterone Change, Age at Peak Testosterone Change, and Testosterone at 17 years of age as well as the timing of the growth spurt during puberty. The average exposure to testosterone is a useful measure for future investigations using testosterone trajectories to examine pubertal dynamics.
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Conceived and designed the experiments: TP EJS. Performed the experiments: LCK CAW. Analyzed the data: AK SMI MTM. Wrote the paper: AK TP.
Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0108838