New Formulation of Paraquat: A Step Forward but in the Wrong Direction?

There was some internal inconsistency in the approaches used to alter the formulation, in that gastric emptying was intended to be delayed by the use of an alginate that would gel in gastric acid.\n Quantities of paraquat ingested in this study were very substantial, and the overall approach of this...

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Vydané v:PLoS medicine Ročník 5; číslo 2; s. e58
Hlavný autor: Bateman, D. Nicholas
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Public Library of Science 01.02.2008
Public Library of Science (PLoS)
Predmet:
Chemistry, Pharmaceutical
Critical Care / Intensive Care
Critical Care and Emergency Medicine
Drug dosages
Emergency Medicine
Humans
Medicine in Developing Countries
Mental Health
Mortality
Nutrition
Paraquat - chemistry
Paraquat - poisoning
Pharmacology
Poisoning
Poisons
Public Health
Public Health and Epidemiology
Suicide
Suicide, Attempted - prevention & control
Suicide, Attempted - trends
Sri Lanka
ISSN:1549-1676, 1549-1277, 1549-1676
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Shrnutí:There was some internal inconsistency in the approaches used to alter the formulation, in that gastric emptying was intended to be delayed by the use of an alginate that would gel in gastric acid.\n Quantities of paraquat ingested in this study were very substantial, and the overall approach of this new formulation would only be effective if a very high proportion of patients are very close to the borderline between a lethal and non-lethal dose--much lower than the median doses ingested by patients in this study. In the more affluent countries of the world, toxicity prevention by product ban may be achievable, but seems less readily acceptable in the economic margins of subsistence farming.
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ISSN:1549-1676
1549-1277
1549-1676
DOI:10.1371/journal.pmed.0050058