New Formulation of Paraquat: A Step Forward but in the Wrong Direction?

There was some internal inconsistency in the approaches used to alter the formulation, in that gastric emptying was intended to be delayed by the use of an alginate that would gel in gastric acid.\n Quantities of paraquat ingested in this study were very substantial, and the overall approach of this...

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Vydané v:PLoS medicine Ročník 5; číslo 2; s. e58
Hlavný autor: Bateman, D. Nicholas
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Public Library of Science 01.02.2008
Public Library of Science (PLoS)
Predmet:
Chemistry, Pharmaceutical
Critical Care / Intensive Care
Critical Care and Emergency Medicine
Drug dosages
Emergency Medicine
Humans
Medicine in Developing Countries
Mental Health
Mortality
Nutrition
Paraquat - chemistry
Paraquat - poisoning
Pharmacology
Poisoning
Poisons
Public Health
Public Health and Epidemiology
Suicide
Suicide, Attempted - prevention & control
Suicide, Attempted - trends
Sri Lanka
ISSN:1549-1676, 1549-1277, 1549-1676
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Abstract There was some internal inconsistency in the approaches used to alter the formulation, in that gastric emptying was intended to be delayed by the use of an alginate that would gel in gastric acid.\n Quantities of paraquat ingested in this study were very substantial, and the overall approach of this new formulation would only be effective if a very high proportion of patients are very close to the borderline between a lethal and non-lethal dose--much lower than the median doses ingested by patients in this study. In the more affluent countries of the world, toxicity prevention by product ban may be achievable, but seems less readily acceptable in the economic margins of subsistence farming.
AbstractList There was some internal inconsistency in the approaches used to alter the formulation, in that gastric emptying was intended to be delayed by the use of an alginate that would gel in gastric acid.\n Quantities of paraquat ingested in this study were very substantial, and the overall approach of this new formulation would only be effective if a very high proportion of patients are very close to the borderline between a lethal and non-lethal dose--much lower than the median doses ingested by patients in this study. In the more affluent countries of the world, toxicity prevention by product ban may be achievable, but seems less readily acceptable in the economic margins of subsistence farming.
The author discusses whether the new paraquat formulation introduced in Sri Lanka is a step forward in reducing deaths from paraquat self-poisoning.
  There was some internal inconsistency in the approaches used to alter the formulation, in that gastric emptying was intended to be delayed by the use of an alginate that would gel in gastric acid.\n Quantities of paraquat ingested in this study were very substantial, and the overall approach of this new formulation would only be effective if a very high proportion of patients are very close to the borderline between a lethal and non-lethal dose--much lower than the median doses ingested by patients in this study. In the more affluent countries of the world, toxicity prevention by product ban may be achievable, but seems less readily acceptable in the economic margins of subsistence farming.
Audience Academic
Author Bateman, D. Nicholas
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CitedBy_id crossref_primary_10_1016_j_toxrep_2014_06_010
crossref_primary_10_3109_15563650_2011_554420
crossref_primary_10_1080_03650341003787582
crossref_primary_10_1080_15563650_2022_2105709
crossref_primary_10_1016_S0140_6736_17_31961_X
crossref_primary_10_3109_15563650_2010_544658
Cites_doi 1471-2458(2007)007[0013:CUOSSB]2.0.CO;2
0011-2232(2007)052[0045:IATPP]2.0.CO;2
0033-5622(2003)096[0809:PFTOPL]2.0.CO;2
0144-5952(1987)006[0031:MOPTIL]2.0.CO;2
0300-483X(2007)241[0001:IOAAFO]2.0.CO;2
0033-5622(1999)092[0573:MLRAOP]2.0.CO;2
0090-3493(2006)034[0368:RPOMAC]2.0.CO;2
0144-5952(1987)006[0057:PTOPP]2.0.CO;2
1549-1676(2008)005[e49:IISAPI]2.0.CO;2
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Copyright COPYRIGHT 2008 Public Library of Science
2008 D. Nicholas Bateman. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Bateman DN (2008) New Formulation of Paraquat: A Step Forward but in the Wrong Direction? PLoS Med 5(2): e58. doi:10.1371/journal.pmed.0050058
2008 D. Nicholas Bateman. 2008
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Snippet There was some internal inconsistency in the approaches used to alter the formulation, in that gastric emptying was intended to be delayed by the use of an...
The author discusses whether the new paraquat formulation introduced in Sri Lanka is a step forward in reducing deaths from paraquat self-poisoning.
  There was some internal inconsistency in the approaches used to alter the formulation, in that gastric emptying was intended to be delayed by the use of an...
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SubjectTerms Chemistry, Pharmaceutical
Critical Care / Intensive Care
Critical Care and Emergency Medicine
Drug dosages
Emergency Medicine
Humans
Medicine in Developing Countries
Mental Health
Mortality
Nutrition
Paraquat - chemistry
Paraquat - poisoning
Pharmacology
Poisoning
Poisons
Public Health
Public Health and Epidemiology
Suicide
Suicide, Attempted - prevention & control
Suicide, Attempted - trends
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Title New Formulation of Paraquat: A Step Forward but in the Wrong Direction?
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https://pubmed.ncbi.nlm.nih.gov/PMC2253614
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http://dx.doi.org/10.1371/journal.pmed.0050058
Volume 5
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