Methicillin Resistance Alters the Biofilm Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated Infections

Clinical isolates of Staphylococcus aureus can express biofilm phenotypes promoted by the major cell wall autolysin and the fibronectin-binding proteins or the icaADBC-encoded polysaccharide intercellular adhesin/poly-N-acetylglucosamine (PIA/PNAG). Biofilm production in methicillin-susceptible S. a...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 8; no. 4; p. e1002626
Main Authors:	Pozzi, Clarissa, Waters, Elaine M., Rudkin, Justine K., Schaeffer, Carolyn R., Lohan, Amanda J., Tong, Pin, Loftus, Brendan J., Pier, Gerald B., Fey, Paul D., Massey, Ruth C., O'Gara, James P.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.04.2012 Public Library of Science (PLoS)
Subjects:	Acetylglucosamine - genetics Acetylglucosamine - metabolism Adaptations Adhesins Adhesins, Bacterial - genetics Adhesins, Bacterial - metabolism Animal models Animals Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics Antibodies Autolysins Bacteriology beta -Lactam antibiotics Biofilms Biofilms - growth & development Biology Cell envelopes Clinical isolates Colonization Data processing Drug resistance Drug resistance in microorganisms Enzymes Equipment Contamination Fibronectin-binding protein Gene Expression Regulation, Bacterial - drug effects Gene Expression Regulation, Bacterial - physiology Genetic aspects Health aspects Hospitals Humans Immunocompromised hosts Immunological tolerance Infection Male MecA protein Medical equipment Medical research Methicillin Methicillin Resistance - drug effects Methicillin Resistance - physiology Methicillin-Resistant Staphylococcus aureus - genetics Methicillin-Resistant Staphylococcus aureus - metabolism Methicillin-Resistant Staphylococcus aureus - pathogenicity Mice Microbial mats Microbiology N-Acetylmuramoyl-L-alanine Amidase - genetics N-Acetylmuramoyl-L-alanine Amidase - metabolism Oxacillin Oxacillin - pharmacology Penicillin Penicillin-Binding Proteins - genetics Penicillin-Binding Proteins - metabolism Phenotype phosphodiesterase Physiological aspects Polysaccharides Polysaccharides, Bacterial - genetics Polysaccharides, Bacterial - metabolism Proteinase Public health Staphylococcus aureus Staphylococcus infections Stress Toxins Transcription Virulence Virulence (Microbiology) United States
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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