Nine residues in HLA-DQ molecules determine with susceptibility and resistance to type 1 diabetes among young children in Sweden

HLA-DQ molecules account over 50% genetic risk of type 1 diabetes (T1D), but little is known about associated residues. Through next generation targeted sequencing technology and deep learning of DQ residue sequences, the aim was to uncover critical residues and their motifs associated with T1D. Our...

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Bibliographic Details
Published in:	Scientific reports Vol. 11; no. 1; pp. 8821 - 19
Main Authors:	Zhao, Lue Ping, Papadopoulos, George K., Moustakas, Antonis K., Bondinas, George P., Carlsson, Annelie, Larsson, Helena Elding, Ludvigsson, Johnny, Marcus, Claude, Persson, Martina, Samuelsson, Ulf, Wang, Ruihan, Pyo, Chul-Woo, Geraghty, Daniel E., Lernmark, Åke
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 23.04.2021 Nature Publishing Group Nature Portfolio
Subjects:	631/208 631/250 692/163 692/308 692/699 Autoimmunity CD4 antigen Clinical Medicine Deep learning Diabetes Diabetes mellitus (insulin dependent) Endocrinology and Diabetes Endokrinologi och diabetes Histocompatibility antigen HLA Humanities and Social Sciences Immunological tolerance Klinisk medicin Medical and Health Sciences Medicin och hälsovetenskap multidisciplinary Pediatrics Pediatrik Residues Science Science (multidisciplinary) T cell receptors
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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