Reactome: a knowledge base of biologic pathways and processes

Reactome http://www.reactome.org , an online curated resource for human pathway data, provides infrastructure for computation across the biologic reaction network. We use Reactome to infer equivalent reactions in multiple nonhuman species, and present data on the reliability of these inferred reacti...

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Published in:Genome biology Vol. 8; no. 3; pp. R39 - 1521
Main Authors: Vastrik, Imre, D'Eustachio, Peter, Schmidt, Esther, Joshi-Tope, Geeta, Gopinath, Gopal, Croft, David, de Bono, Bernard, Gillespie, Marc, Jassal, Bijay, Lewis, Suzanna, Matthews, Lisa, Wu, Guanming, Birney, Ewan, Stein, Lincoln
Format: Journal Article
Language:English
Published: England BioMed Central 16.03.2007
Subjects:
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Animals
BASIC BIOLOGICAL SCIENCES
biologic process
Computational Biology - methods
computer software
data collection
Databases as Topic
eukaryotic cells
Humans
inference algorithm
infrastructure
Internet
Knowledge Bases
learning
Metabolic Networks and Pathways
Microarray Analysis
microarray technology
physical entity
Saccharomyces cerevisiae
Software
system biology markup language
Systems Biology
ISSN:1474-760X, 1465-6906, 1474-760X, 1465-6914
Online Access:Get full text
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Summary:Reactome http://www.reactome.org , an online curated resource for human pathway data, provides infrastructure for computation across the biologic reaction network. We use Reactome to infer equivalent reactions in multiple nonhuman species, and present data on the reliability of these inferred reactions for the distantly related eukaryote Saccharomyces cerevisiae . Finally, we describe the use of Reactome both as a learning resource and as a computational tool to aid in the interpretation of microarrays and similar large-scale datasets.
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content type line 23
European Union Sixth Framework
AC02-05CH11231; R01HG002639; LSHG-CT-2003-503269
National Institutes of Health (NIH)
USDOE Office of Science (SC), Biological and Environmental Research (BER)
ISSN:1474-760X
1465-6906
1474-760X
1465-6914
DOI:10.1186/gb-2007-8-3-r39