Broad-Spectrum Antibiotic Treatment and Subsequent Childhood Type 1 Diabetes: A Nationwide Danish Cohort Study

Studies link antibiotic treatment and delivery by cesarean section with increased risk of chronic diseases through changes of the gut-microbiota. We aimed to evaluate the association of broad-spectrum antibiotic treatment during the first two years of life with subsequent onset of childhood type 1 d...

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Bibliographic Details
Published in:	PloS one Vol. 11; no. 8; p. e0161654
Main Authors:	Clausen, Tine D., Bergholt, Thomas, Bouaziz, Olivier, Arpi, Magnus, Eriksson, Frank, Rasmussen, Steen, Keiding, Niels, Løkkegaard, Ellen C.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 25.08.2016 Public Library of Science (PLoS)
Subjects:	Adolescent Analysis Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - therapeutic use Antibiotics Antimicrobial agents Biology and Life Sciences Care and treatment Cesarean section Cesarean Section - adverse effects Child Child, Preschool Childhood Children Children & youth Chronic diseases Chronic illnesses Cohort analysis Cohort Studies Complications and side effects Delivery, Obstetric - adverse effects Denmark Development and progression Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - epidemiology Dosage and administration Emigration Female Gynecology Health aspects Health risks Hospitals Human health and pathology Humans Immune system Infections Insulin Intestinal microflora Lactation Life Sciences Male Medicine and Health Sciences Microbiota Microbiota (Symbiotic organisms) Mortality Multiple births Obstetrics Pediatrics Penicillin People and Places Personal identification numbers Pharmaceutical sciences Population Pregnancy Proportional Hazards Models Public health Registries Risk Santé publique et épidémiologie Studies Type 1 diabetes Denmark Pregnancy Survival analysis Cox model Antibiotics Penicillin Children Diabetes Mellitus Cesarean section Labor and delivery
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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