Skeletal Muscle Insulin Resistance and Absence of Inflammation Characterize Insulin-Resistant Grade I Obese Women

Obesity is associated with insulin-resistance (IR), the key feature of type 2 diabetes. Although chronic low-grade inflammation has been identified as a central effector of IR development, it has never been investigated simultaneously at systemic level and locally in skeletal muscle and adipose tiss...

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Bibliographic Details
Published in:	PloS one Vol. 11; no. 4; p. e0154119
Main Authors:	Amouzou, Cacylde, Breuker, Cyril, Fabre, Odile, Bourret, Annick, Lambert, Karen, Birot, Olivier, Fédou, Christine, Dupuy, Anne-Marie, Cristol, Jean-Paul, Sutra, Thibault, Molinari, Nicolas, Maimoun, Laurent, Mariano-Goulart, Denis, Galtier, Florence, Avignon, Antoine, Stanke-Labesque, Françoise, Mercier, Jacques, Sultan, Ariane, Bisbal, Catherine
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 25.04.2016 Public Library of Science (PLoS)
Subjects:	Adipose tissue AKT protein Biology and Life Sciences Blood Glucose - metabolism Body mass Body mass index Body size C-Reactive Protein Case-Control Studies Cell Movement - drug effects Comparative analysis Complications and side effects Cytokines Development and progression Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Diet Female Gene Expression Regulation Glucose Glucose Clamp Technique Homeostasis Humans Infiltration Inflammation Insulin Insulin - administration & dosage Insulin - metabolism Insulin Resistance Interleukin 6 Interleukin-6 - genetics Interleukin-6 - metabolism Kinases Life Sciences Lipids Lipopolysaccharides Macrophages Macrophages - drug effects Macrophages - metabolism Macrophages - pathology Medicine and Health Sciences Middle Aged Muscle, Skeletal - metabolism Muscle, Skeletal - physiopathology Muscles NF-KappaB Inhibitor alpha - genetics NF-KappaB Inhibitor alpha - metabolism Obesity Parameter sensitivity Phosphorylation Physiological aspects Postmenopause - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Quality Risk factors Sensitivity Sensitivity analysis Severity of Illness Index Skeletal muscle Subcutaneous Fat - metabolism Subcutaneous Fat - physiopathology Surveys and Questionnaires Tissues France
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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