Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic...

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Veröffentlicht in:	Nature genetics Jg. 53; H. 6; S. 817 - 829
Hauptverfasser:	Mullins, Niamh, O’Connell, Kevin S., Coleman, Jonathan R. I., Qiao, Zhen, Bigdeli, Tim B., Hagenaars, Saskia P., Krebs, Kristi, Panagiotaropoulou, Georgia, Schilder, Brian M., Sloofman, Laura G., Winsvold, Bendik S., Al Eissa, Mariam, Albani, Diego, Alliey-Rodriguez, Ney, Antoniou, Anastasia, Beins, Eva C., Boks, Marco P., Brum, Murielle, Byerley, William, Cairns, Murray, Cervantes, Pablo, Cuellar-Barboza, Alfredo, Czerski, Piotr M., Djurovic, Srdjan, Douzenis, Athanassios, Foroud, Tatiana M., Giørtz Pedersen, Marianne, Gordon-Smith, Katherine, Grove, Jakob, Guzman-Parra, José, Haraldsson, Magnus, Herms, Stefan, Hoffmann, Per, Holmans, Peter A., Huckins, Laura, Johnson, Jessica S., Kalman, Janos L., Knowles, James A., Koromina, Maria, Kranzler, Henry R., Lee, Phil H., Lewis, Catrin, Lundberg, Martin, MacIntyre, Donald J., Magnusson, Sigurdur H., Maier, Wolfgang, Medland, Sarah E., Moran, Jennifer L., O’Brien, Niamh, Olde Loohuis, Loes M., Oruc, Lilijana, Papiol, Sergi, Pardiñas, Antonio F., Perry, Amy, Sánchez-Mora, Cristina, Sharp, Sally, Spijker, Anne T., Stein, Dan J., Strauss, John S., Tooney, Paul, Tsermpini, Evangelia-Eirini, Vedder, Helmut, Walters, James T. R., Witt, Stephanie H., Babadjanova, Gulja, Blackwood, Douglas H. R., Carr, Vaughan J., Dannlowski, Udo, Dikeos, Dimitris, Etain, Bruno, Frye, Mark, Gershon, Elliot S., Goes, Fernando S., Grigoroiu-Serbanescu, Maria, Hougaard, David M., Hveem, Kristian, Jablensky, Assen V., Kirov, George, Lewis, Cathryn M., Loughland, Carmel, Martin, Nicholas G., McElroy, Susan L., Melle, Ingrid, Milani, Lili, Nievergelt, Caroline M., Nöthen, Markus M., O’Donovan, Michael C., Oedegaard, Ketil J., Olsson, Tomas, Perlis, Roy H., Ribasés, Marta, Rouleau, Guy A., Schalling, Martin, Schulze, Thomas G., Serretti, Alessandro, Smoller, Jordan W., Stefansson, Kari, Stordal, Eystein, Vieta, Eduard, Nurnberger, John I.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.06.2021 Nature Publishing Group
Schlagworte:	45 45/43 631/208/205/2138 692/699/476/1333 Agriculture Anesthetics Animal Genetics and Genomics Antipsychotics Biomedical and Life Sciences Biomedicine Bipolar Disorder Bipolar Disorder - genetics Calcium Calcium channel blockers Calcium channels Cancer Research Case-Control Studies Chromosomes, Human Chromosomes, Human - genetics Consortia Diagnosis educational-attainment Etiology Furin Gene expression Gene Function Gene loci Gene mapping Genes Genetic aspects Genetic Predisposition to Disease Genetics & Heredity Genome, Human Genome-wide association studies Genome-Wide Association Study Genomes Genomics genotype imputation Human Genetics Human health and pathology Humans identification ld score regression Life Sciences loci Major Histocompatibility Complex Major Histocompatibility Complex - genetics Mental disorders Meta-analysis Multifactorial Inheritance Multifactorial Inheritance - genetics Neurosciences Neurovetenskaper Phenotype polygenicity Population Prefrontal cortex prevalence Psychiatrics and mental health Psychotropic drugs Quantitative Trait Loci Quantitative Trait Loci - genetics risk Risk Factors schizophrenia spectrum disorder Australia North America Europe
ISSN:	1061-4036, 1546-1718, 1546-1718
Online-Zugang:	Volltext
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