Suggestions from Geroscience for the Genetics of Age-Related Diseases

[...]the authors were able to validate risk loci buried in well studied datasets. The revolution in hygiene awareness, a major contributor to the unprecedented increase of life expectancy, and the concomitant emergence of an obesogenic environment (easy access to nutrient-rich food; reduced physical...

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Vydáno v:PLoS genetics Ročník 12; číslo 11; s. e1006399
Hlavní autoři: Franceschi, Claudio, Garagnani, Paolo
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Public Library of Science 10.11.2016
Public Library of Science (PLoS)
Témata:
Age
Aging
Aging (Biology)
Biology and Life Sciences
Body mass index
Centenarians
Datasets
Demography
Funding
Gene expression
Genetic aspects
Genetics
Genomes
Health aspects
Medicine and Health Sciences
Mortality
People and Places
Research and Analysis Methods
Studies
Italy
ISSN:1553-7404, 1553-7390, 1553-7404
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Shrnutí:[...]the authors were able to validate risk loci buried in well studied datasets. The revolution in hygiene awareness, a major contributor to the unprecedented increase of life expectancy, and the concomitant emergence of an obesogenic environment (easy access to nutrient-rich food; reduced physical activity) exemplify changes that promoted the epidemiological explosion of obesity, metabolic disorders, and eventually of major age-associated diseases. [...]subsequent generations were exposed to quite different environmental conditions and pressures during the last century, and it is easy to predict that the risk/protective effects of specific alleles changed accordingly.
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The authors have declared that no competing interests exist.
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1006399