Lysophosphatidylcholine Acyltransferase1 Overexpression Promotes Oral Squamous Cell Carcinoma Progression via Enhanced Biosynthesis of Platelet-Activating Factor

The relevance of lysophosphatidylcholine acyltransferase1 (LPCAT1), a cytosolic enzyme in the remodeling pathway of phosphatidylcholine metabolism, in oral squamous cell carcinoma (OSCC) is unknown. We investigated LPCAT1 expression and its functional mechanism in OSCCs. We analyzed LPCAT1 mRNA and...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 3; p. e0120143
Main Authors:	Shida-Sakazume, Tomomi, Endo-Sakamoto, Yosuke, Unozawa, Motoharu, Fukumoto, Chonji, Shimada, Ken, Kasamatsu, Atsushi, Ogawara, Katsunori, Yokoe, Hidetaka, Shiiba, Masashi, Tanzawa, Hideki, Uzawa, Katsuhiro
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 24.03.2015 Public Library of Science (PLoS)
Subjects:	1-Acylglycerophosphocholine O-Acyltransferase - genetics 1-Acylglycerophosphocholine O-Acyltransferase - metabolism Analysis Angiogenesis Biosynthesis Biotechnology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell adhesion & migration Cell culture Cell Line, Tumor Cell Proliferation Chemical properties Chemotherapy Correlation Dentistry Down-regulation Enzymes Ethics Functional analysis Gene expression Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Humans Immunohistochemistry Inflammation Invasiveness Keratinocytes Kinases Laboratories Lecithin Liver cancer Lymph nodes Lysophosphatidylcholine Maxillofacial surgery Medicine Melanoma Metabolism Metastases Metastasis Mouth - metabolism Mouth - pathology Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Mouth Neoplasms - pathology mRNA Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Oral cancer Oral squamous cell carcinoma Penicillin Phosphatidylcholine Phospholipids Platelet Activating Factor - metabolism Platelet Membrane Glycoproteins - genetics Platelet Membrane Glycoproteins - metabolism Platelet-activating factor Prostate Proteins Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism RNA RNA, Messenger - genetics Rodents Science Squamous cell carcinoma Surgery Tumor Cells, Cultured Up-Regulation United States > US Japan
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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