Lipopolysaccharide Induces Inflammatory Hyperalgesia Triggering a TLR4/MyD88-Dependent Cytokine Cascade in the Mice Paw

Inflammatory pain can be triggered by different stimuli, such as trauma, radiation, antigen and infection. In a model of inflammatory pain caused by infection, injection in the mice paw of lipopolysaccharide (LPS), a Toll-like receptor 4 (TLR4) agonist, produces mechanical hyperalgesia. We identify...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 3; p. e90013
Main Authors:	Calil, Igor L., Zarpelon, Ana C., Guerrero, Ana T. G., Alves-Filho, Jose C., Ferreira, Sergio H., Cunha, Fernando Q., Cunha, Thiago M., Verri, Waldiceu A.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 03.03.2014 Public Library of Science (PLoS)
Subjects:	Analysis Animals Biology Cytokines Cytokines - metabolism Foot - pathology Guanethidine Health aspects Hyperalgesia Hyperalgesia - chemically induced Indomethacin Infections Inflammation Inflammation - chemically induced Injection Interleukin 1 Interleukin 1 receptor antagonist Lipopolysaccharides Lipopolysaccharides - pharmacology Male Medicine Mice Mice, Inbred C57BL Mice, Knockout Mitogens MyD88 protein Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism Pain Pain perception Peroxidase Prostaglandins Radiation Signal Transduction Signaling Skin Stress, Mechanical TLR4 protein Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors Trauma Tumor necrosis factor receptors Tumor necrosis factor-α
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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