Hepatocyte Expression of the Senescence Marker p21 Is Linked to Fibrosis and an Adverse Liver-Related Outcome in Alcohol-Related Liver Disease

Alcohol-related liver disease (ALD) remains a leading cause of liver-related morbidity and mortality. Age, fibrosis stage, MELD score and continued alcohol consumption predict outcome in everyday clinical practice. In previous studies increased hepatocyte nuclear area and hepatocyte expression of p2...

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Veröffentlicht in:	PloS one Jg. 8; H. 9; S. e72904
Hauptverfasser:	Aravinthan, Aloysious, Pietrosi, Giada, Hoare, Matthew, Jupp, James, Marshall, Aileen, Verrill, Clare, Davies, Susan, Bateman, Adrian, Sheron, Nick, Allison, Michael, Alexander, Graeme J. M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 23.09.2013 Public Library of Science (PLoS)
Schlagworte:	Adult Aged Alcohol use Alcohols Automation Biomarkers - metabolism Biopsy Cell activation Cell cycle Cellular Senescence Cirrhosis Cohort Studies Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - metabolism Drinking (Alcoholic beverages) Fatty liver Female Fibrosis Gene expression Health aspects Hepatitis Hepatocytes - metabolism Hepatology Histology Histopathology Hospitals Humans Immunohistochemistry Liver Liver cancer Liver cirrhosis Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver diseases Liver Diseases, Alcoholic - metabolism Liver Diseases, Alcoholic - pathology Liver transplants Male Markers Medical prognosis Medical research Medicine Metastasis Middle Aged Morbidity Mortality Patients Phase distribution Prognosis Rodents S phase Senescence United Kingdom > UK
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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