Quercetin as a potential treatment for COVID-19-induced acute kidney injury: Based on network pharmacology and molecular docking study

Kidneys are one of the targets for SARS-CoV-2, it is reported that up to 36% of patients with SARS-CoV-2 infection would develop into acute kidney injury (AKI). AKI is associated with high mortality in the clinical setting and contributes to the transition of AKI to chronic kidney disease (CKD). Up...

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Bibliographic Details
Published in:	PloS one Vol. 16; no. 1; p. e0245209
Main Authors:	Gu, Yue-Yu, Zhang, Min, Cen, Huan, Wu, Yi-Fan, Lu, Zhaoyu, Lu, Fuhua, Liu, Xu-Sheng, Lan, Hui-Yao
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 14.01.2021 Public Library of Science (PLoS)
Subjects:	ACE2 Acute Kidney Injury - drug therapy Acute Kidney Injury - virology Acute renal failure Angiotensin Angiotensin-converting enzyme 2 Anti-inflammatory drugs Antibodies Biology and life sciences Coronaviridae Coronaviruses COVID-19 COVID-19 - drug therapy COVID-19 - physiopathology Creatinine Crystal structure Data analysis Databases, Factual Databases, Genetic Disease Drug therapy Flavonoids Genes Gu, Min Health risks Health services Hematuria Herbal medicine Hospitals Humans Infections Kidneys Ligands Medicine Medicine and Health Sciences Molecular docking Molecular Docking Simulation Morbidity Nephrology Ontology Pandemics Peptidyl-dipeptidase A Pharmacology Pharmacology, Experimental Physical Sciences Pneumonia Protein Interaction Mapping - methods Protein Interaction Maps Proteins Proteinuria Quercetin Quercetin - pharmacology Renal tubules Respiratory diseases Respiratory system SARS-CoV-2 - drug effects SARS-CoV-2 - isolation & purification Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Ultrasound Urea Vaccines Viral diseases China
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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