Quercetin as a potential treatment for COVID-19-induced acute kidney injury: Based on network pharmacology and molecular docking study

Kidneys are one of the targets for SARS-CoV-2, it is reported that up to 36% of patients with SARS-CoV-2 infection would develop into acute kidney injury (AKI). AKI is associated with high mortality in the clinical setting and contributes to the transition of AKI to chronic kidney disease (CKD). Up...

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Veröffentlicht in:	PloS one Jg. 16; H. 1; S. e0245209
Hauptverfasser:	Gu, Yue-Yu, Zhang, Min, Cen, Huan, Wu, Yi-Fan, Lu, Zhaoyu, Lu, Fuhua, Liu, Xu-Sheng, Lan, Hui-Yao
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 14.01.2021 Public Library of Science (PLoS)
Schlagworte:	ACE2 Acute Kidney Injury - drug therapy Acute Kidney Injury - virology Acute renal failure Angiotensin Angiotensin-converting enzyme 2 Anti-inflammatory drugs Antibodies Biology and life sciences Coronaviridae Coronaviruses COVID-19 COVID-19 - drug therapy COVID-19 - physiopathology Creatinine Crystal structure Data analysis Databases, Factual Databases, Genetic Disease Drug therapy Flavonoids Genes Gu, Min Health risks Health services Hematuria Herbal medicine Hospitals Humans Infections Kidneys Ligands Medicine Medicine and Health Sciences Molecular docking Molecular Docking Simulation Morbidity Nephrology Ontology Pandemics Peptidyl-dipeptidase A Pharmacology Pharmacology, Experimental Physical Sciences Pneumonia Protein Interaction Mapping - methods Protein Interaction Maps Proteins Proteinuria Quercetin Quercetin - pharmacology Renal tubules Respiratory diseases Respiratory system SARS-CoV-2 - drug effects SARS-CoV-2 - isolation & purification Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Ultrasound Urea Vaccines Viral diseases China
ISSN:	1932-6203, 1932-6203
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Zusammenfassung:	Kidneys are one of the targets for SARS-CoV-2, it is reported that up to 36% of patients with SARS-CoV-2 infection would develop into acute kidney injury (AKI). AKI is associated with high mortality in the clinical setting and contributes to the transition of AKI to chronic kidney disease (CKD). Up to date, the underlying mechanisms are obscure and there is no effective and specific treatment for COVID-19-induced AKI. In the present study, we investigated the mechanisms and interactions between Quercetin and SARS-CoV-2 targets proteins by using network pharmacology and molecular docking. The renal protective effects of Quercetin on COVID-19-induced AKI may be associated with the blockade of the activation of inflammatory, cell apoptosis-related signaling pathways. Quercetin may also serve as SARS-CoV-2 inhibitor by binding with the active sites of SARS-CoV-2 main protease 3CL and ACE2, therefore suppressing the functions of the proteins to cut the viral life cycle. In conclusion, Quercetin may be a novel therapeutic agent for COVID-19-induced AKI. Inhibition of inflammatory, cell apoptosis-related signaling pathways may be the critical mechanisms by which Quercetin protects kidney from SARS-CoV-2 injury.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0245209