An Important Role of the SDF-1/CXCR4 Axis in Chronic Skin Inflammation

Inflammatory angiogenesis and vascular remodeling play key roles in the chronic inflammatory skin disease psoriasis, but little is known about the molecular mediators of vascular activation. Based on the reported elevated mRNA levels of the angiogenic chemokine stromal cell-derived factor-1 (SDF-1)...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 4; p. e93665
Main Authors:	Zgraggen, Silvana, Huggenberger, Reto, Kerl, Katrin, Detmar, Michael
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.04.2014 Public Library of Science (PLoS)
Subjects:	Aminoquinolines - therapeutic use Analysis Angiogenesis Animal models Animals Biology and Life Sciences Blood vessels Care and treatment CD11b antigen CD4 antigen CD8 antigen Chemokine CXCL12 - physiology Chemokines Chemotaxis Chronic Disease CXCR4 protein Dermatitis Dermatitis - drug therapy Dermatitis - physiopathology Diagnosis Disease Imiquimod Inflammation Inhibition Lymphatic system Lymphocytes Lymphocytes T Macrophages Medicine and Health Sciences Mice Mice, Inbred C57BL mRNA Neovascularization, Pathologic Pharmaceutical sciences Psoriasis Receptors, CXCR4 - physiology Rheumatoid arthritis Risk factors Rodents SDF-1 protein Skin Skin diseases Splenocytes Systematic review Transgenic mice Up-Regulation Vascular endothelial growth factor
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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