The Transcription Factor Runx2 Is under Circadian Control in the Suprachiasmatic Nucleus and Functions in the Control of Rhythmic Behavior

Runx2, a member of the family of runt-related transcription factors, is rhythmically expressed in bone and may be involved in circadian rhythms in bone homeostasis and osteogenesis. Runx2 is also expressed in the brain, but its function is unknown. We tested the hypothesis that in the brain, Runx2 m...

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Bibliographic Details
Published in:	PloS one Vol. 8; no. 1; p. e54317
Main Authors:	Reale, Meghan E., Webb, Ian C., Wang, Xu, Baltazar, Ricardo M., Coolen, Lique M., Lehman, Michael N.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 25.01.2013 Public Library of Science (PLoS)
Subjects:	Analysis Animal behavior Animals ARNTL Transcription Factors - deficiency ARNTL Transcription Factors - genetics Biocompatibility Biological clocks Biology Bioluminescence Biomedical materials BMAL1 protein Bone turnover Brain Cbfa-1 protein Circadian Clocks - genetics Circadian rhythm Circadian Rhythm - genetics Circadian rhythms Clock gene CLOCK protein Core Binding Factor Alpha 1 Subunit - deficiency Core Binding Factor Alpha 1 Subunit - genetics Diurnal DNA binding proteins Gene expression Gene Expression Regulation Genes Homeostasis Male Mice Mice, Transgenic Motor Activity - physiology Mutation Nuclei Olfactory bulb Olfactory Bulb - physiology Osteogenesis Paraventricular Hypothalamic Nucleus - physiology Paraventricular nucleus Period 1 protein Period 2 protein Period Circadian Proteins - genetics Period Circadian Proteins - metabolism Rhythms RNA RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Signal Transduction Suprachiasmatic nucleus Suprachiasmatic Nucleus - physiology Transcription factors Transcription, Genetic Wheel running Ontario Canada Canada Mississippi United States > US
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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