Statin Therapy and Mortality in HIV-Infected Individuals; A Danish Nationwide Population-Based Cohort Study

Recent studies have suggested that statins possess diverse immune modulatory and anti-inflammatory properties. As statins might attenuate inflammation, statin therapy has been hypothesized to reduce mortality in HIV-infected individuals. We therefore used a Danish nationwide cohort of HIV-infected i...

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Bibliographic Details
Published in:	PloS one Vol. 8; no. 3; p. e52828
Main Authors:	Rasmussen, Line D., Kronborg, Gitte, Larsen, Carsten S., Pedersen, Court, Gerstoft, Jan, Obel, Niels
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 04.03.2013 Public Library of Science (PLoS)
Subjects:	Acquired immune deficiency syndrome Adult AIDS Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Anti-inflammatory agents Antiretroviral drugs Antiretroviral Therapy, Highly Active Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - drug therapy Cardiovascular Diseases - mortality Cohort analysis Comorbidity Denmark Denmark - epidemiology Diabetes mellitus Diabetes Mellitus - drug therapy Diabetes Mellitus - mortality Diagnosis Failure analysis Female Forecasts and trends Health risk assessment Highly active antiretroviral therapy HIV HIV Infections - drug therapy HIV Infections - mortality HIV patients Human immunodeficiency virus Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Identification methods Inflammation Male Medical diagnosis Medicine Middle Aged Mortality Patient outcomes Physiological aspects Poisson density functions Population studies Population-based studies Predictive control Regression analysis Renal Insufficiency, Chronic - drug therapy Renal Insufficiency, Chronic - mortality Statins Statistical analysis Studies Survival Analysis Therapy Viral Load Denmark
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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