Use of Self-Complementary Adeno-Associated Virus Serotype 2 as a Tracer for Labeling Axons: Implications for Axon Regeneration

Various types of tracers are available for use in axon regeneration, but they require an extra operational tracer injection, time-consuming immunohistochemical analysis and cause non-specific labeling. Considerable efforts over the past years have explored other methodologies, especially the use of...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 2; p. e87447
Main Authors:	Liu, Yingpeng, Keefe, Kathy, Tang, Xiaoqing, Lin, Shen, Smith, George M.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 03.02.2014 Public Library of Science (PLoS)
Subjects:	Adenoviruses Analysis Animal models Animals Axons Axons - metabolism Axons - physiology Biology Brain - metabolism Brain research Cortex (somatosensory) Deoxyribonucleic acid Dependovirus - genetics DNA Dorsal root ganglia Fibers Fibroblasts Ganglia, Spinal - metabolism Gene expression Gene therapy Genetic Vectors - genetics Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism HEK293 Cells Hospitals Humans Injuries Labeling Labelling Laboratory animals Lesions Luminescent Proteins - genetics Luminescent Proteins - metabolism Medicine Microscopy, Fluorescence Motor neurons Motor Neurons - metabolism Nerve Regeneration Neurons Pediatrics Plasmids Pyramidal tracts Rats Rats, Inbred F344 Red Fluorescent Protein Red nucleus Regeneration Rodents Rubrospinal tract Sensory neurons Sensory Receptor Cells - metabolism Somatosensory cortex Spinal cord Spinal Cord - metabolism Spinal cord injuries Spinal Nerve Roots - metabolism Tracers Tracers (Biology) Transgenes Vectors (Biology) Viruses
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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