Imaging correlates of visual function in multiple sclerosis
No single neuroimaging technique or sequence is capable of reflecting the functional deficits manifest in MS. Given the interest in imaging biomarkers for short- to medium-term studies, we aimed to assess which imaging metrics might best represent functional impairment for monitoring in clinical tri...
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| Vydáno v: | PloS one Ročník 15; číslo 8; s. e0235615 |
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| Hlavní autoři: | , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
Public Library of Science
03.08.2020
Public Library of Science (PLoS) |
| Témata: | |
| ISSN: | 1932-6203, 1932-6203 |
| On-line přístup: | Získat plný text |
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| Shrnutí: | No single neuroimaging technique or sequence is capable of reflecting the functional deficits manifest in MS. Given the interest in imaging biomarkers for short- to medium-term studies, we aimed to assess which imaging metrics might best represent functional impairment for monitoring in clinical trials. Given the complexity of functional impairment in MS, however, it is useful to isolate a particular functionally relevant pathway to understand the relationship between imaging and neurological function. We therefore analyzed existing data, combining multiparametric MRI and OCT to describe MS associated visual impairment. We assessed baseline data from fifty MS patients enrolled in ReBUILD, a prospective trial assessing the effect of a remyelinating drug (clemastine). Subjects underwent 3T MRI imaging, including Neurite Orientation Dispersion and Density Imaging (NODDI), myelin content quantification, and retinal imaging, using OCT. Visual function was assessed, using low-contrast letter acuity. MRI and OCT data were studied to model visual function in MS, using a partial, least-squares, regression analysis. Measures of neurodegeneration along the entire visual pathway, described most of the observed variance in visual disability, measured by low contrast letter acuity. In those patients with an identified history of ON, however, putative myelin measures also showed correlation with visual performance. In the absence of clinically identifiable inflammatory episodes, residual disability correlates with neurodegeneration, whereas after an identifiable exacerbation, putative measures of myelin content are additionally informative. |
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| Bibliografie: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have read the journal’s policy and have the following potential competing interests: SLH serves on the Board of Directors for Neurona, on the Scientific Advisory Board for Alector, Annexon, Bionure, and Molecular Stethoscope, and he has also received non-financial support from F. Hoffmann-La Roche Ltd and Novartis AG. AB has received travel fees from Actelion and speaker fees from Biogen. JMG reports research support to UCSF from Genentech for a clinical trial and consulting for Biogen and Alexion. BACC has received personal compensation for consulting from Akili, Alexion, Atara, Biogen, EMD Serono, Novartis, Sanofi and TG Therapeutics. AJG has served on the Scientific Advisory Board for Bionure, Inception Sciences and Pipeline Therapeutics. He serves as an Associate Editor at JAMA Neurology. He has served on an Adjudication Committee for MedImmune/Viela Bio. He has provided expert support for Mylan, Synthon and Pharmasciences and personal fees from and other financial relationships with Pipeline Therapeutics. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products to declare. All other authors have declared that no competing interests exist. |
| ISSN: | 1932-6203 1932-6203 |
| DOI: | 10.1371/journal.pone.0235615 |