mTOR-Dependent and Independent Survival Signaling by PI3K in B Lymphocytes

Peripheral B lymphocyte survival requires the B cell receptor (BCR) and B cell activating factor (BAFF) binding to its receptor (BAFF-R). Deletion of the BCR, or its signal transducing chaperone Igβ, leads to rapid loss of mature B cells, indicating that signals initiated at the BCR are crucial for...

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Bibliographic Details
Published in:	PloS one Vol. 11; no. 1; p. e0146955
Main Authors:	Kaileh, Mary, Vazquez, Estefania, MacFarlane, Alexander W., Campbell, Kerry, Kurosaki, Tomohiro, Siebenlist, Ulrich, Sen, Ranjan
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 19.01.2016 Public Library of Science (PLoS)
Subjects:	1-Phosphatidylinositol 3-kinase Animals Antigens Apoptosis B cells B-Cell Activating Factor - pharmacology B-Cell Activation Factor Receptor - metabolism B-cell receptor B-Lymphocytes - cytology B-Lymphocytes - metabolism BLyS protein Bone marrow Cancer Cell Survival Cells, Cultured Cellular signal transduction Clonal deletion Gene expression Genetic aspects Homeostasis Immunology Infectious diseases Kinases Laboratories Lymphocyte receptors Lymphocytes Lymphocytes B Lymphoma Mcl-1 protein Medical research Mice Molecular biology Myeloid Cell Leukemia Sequence 1 Protein - genetics NF-kappa B p52 Subunit - genetics Phosphatidylinositol 3-Kinases - metabolism Physiological aspects Post-transcription Protein kinases Proto-Oncogene Proteins c-bcr - metabolism Signal Transduction Signaling Spleen Survival TOR protein TOR Serine-Threonine Kinases - metabolism United States Japan
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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